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Antipsychotic

Ziprasidone for Schizophrenia

Phase 1

Waitlist Available

Led By Amelia Gallitano, MD,PhD

Research Sponsored by University of Arizona

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 2 years

Awards & highlights

Study Summary

This trial is testing a potential new method for diagnosing schizophrenia by measuring a patient's response to a sedative medication.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Chalder Fatigue Scale

Electroencephalogram

Epworth Sleepiness Scale

+6 more

Trial Design

3Treatment groups

Experimental Treatment

Placebo Group

Group I: ZiprasidoneExperimental Treatment3 Interventions

The investigators will conduct a pilot dose-response evaluation of a single dose of the anti-psychotic drug ziprasidone (Geodon). The investigators will start with a single 20mg pill given to (3) subjects and will increase the dosage in sequential subjects until the desired sedation effect is achieved (i.e. 40 and 60mg tablets). If Ziprasidone causes the desired sedation effect additional healthy subjects will be recruited to take the medication and have an electroencephalogram (EEG) taken.

Group II: OlanzapineExperimental Treatment2 Interventions

The investigators will conduct a pilot dose-response evaluation of a single dose of the anti-psychotic drug olanzapine (Zyprexa). The investigators will start with a single 2.5 mg pill given to (3) subjects and will increase the dosage in sequential subjects until the desired sedation effect is achieved (i.e. 5, 7.5, and 10 mg tablets).If olanzapine causes the desired sedation effect additional healthy subjects will be recruited to take the medication and have an electroencephalogram (EEG).

Group III: Placebo ComparatorPlacebo Group2 Interventions

The investigators have prepared a placebo which duplicates the exact color and size of the study drug capsule to use as a non-drug control.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Olanzapine

2005

Completed Phase 4

~5480

Ziprasidone

2006

Completed Phase 4

~3590

Placebo Comparator

2008

Completed Phase 4

~3520

Do I qualify?Apply below to find out

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of ArizonaLead Sponsor

514 Previous Clinical Trials

148,249 Total Patients Enrolled

3 Trials studying Schizophrenia

152 Patients Enrolled for Schizophrenia

Sidney R. Baer, Jr. FoundationOTHER

2 Previous Clinical Trials

35 Total Patients Enrolled

1 Trials studying Schizophrenia

22 Patients Enrolled for Schizophrenia

Amelia Gallitano, MD,PhDPrincipal InvestigatorUniversity of Arizona College of Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How likely are adverse reactions to Ziprasidone in clinical settings?

"Due to the lack of available clinical evidence for Ziprasidone's safety and efficacy, we rated its risk at 1."

Answered by AI

Does the cutoff age for this clinical experiment extend past 75 years of age?

"This trial only welcomes individuals aged between 18 to 40. However, there are 50 clinical studies for minors and 177 trials focused on patients above 65 years of age."

Answered by AI

Is it still feasible for individuals to join this medical experiment?

"Affirmatively, the clinicaltrials.gov platform confirms that this medical study is still enrolling participants. It was first posted on November 20th 2017 and revised most recently in February 23rd 2022 with a view to recruiting 24 volunteers from 2 sites."

Answered by AI

Is it possible for me to become a research participant in this trial?

"This trial is accepting applicants aged 18 - 40 who have been diagnosed with schizophrenia. A maximum of 24 participants will be included in the research project."

Answered by AI

What ailments are generally treated with Ziprasidone?

"Ziprasidone is the go-to drug used to manage acute coryza, while also helping individuals struggling with mental depression, dementia and other mixed manic depressive episodes."

Answered by AI

Has Ziprasidone been investigated in any other research studies?

"The current clinical landscape for Ziprasidone comprises of 20 ongoing studies, 4 of which are currently at Phase 3. Shreveport, Louisiana is a key hub for these trials; however, there are 707 sites around the world offering this medication to patients."

Answered by AI

What is the scope of enrollment for this clinical trial?

"Affirmative, the information published on clinicaltrials.gov shows that this experiment is actively recruiting volunteers. It was initially posted on November 20th 2017 and has since been updated as recently as February 23rd 2022. 24 participants are being sought out between 2 different test sites."

Answered by AI

Is this exploration the inaugural of its category?

"Presently, there are 20 active clinical trials involving ziprasidone being conducted in 402 cities and 7 nations. The first of these studies was sponsored by Eli Lilly & Company back in 2007 and involved a cohort of 20 subjects that completed the necessary phases for drug approval. Subsequently, 374 additional research projects have been finalized since then."

Answered by AI