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Prostaglandin E1 Analog

Atorvastatin + Misoprostol for Pregnancy Termination

Q: Is this experiment accommodating elderly individuals?

Eligibility for this study necessitates that participants be aged 18 or older, and under 50 years of age.

Q: Is the recruitment for this clinical experiment still open?

Per the details on clinicaltrials.gov, this research is currently enrolling participants. It was initially posted in April of 2022 and its data was most recently updated at the end of October that same year.

Q: What type of participants are most suitable for this research?

This clinical trial seeks 30 individuals aged between 18 and 50 who have experienced an early abortion. The prospective participants must be able to speak English or Spanish, willing to postpone their termination of <a href="https://www.withpower.com/clinical-trials/pregnancy">pregnancy</a> by up to two weeks, abstain from contraception until the completion of their abortion procedure, comply with <a href="https://www.withpower.com/clinical-trials/all">all</a> protocol requirements, and accept that they may require a uterine aspiration in order for the study regimen to successfully terminate their pregnancy.

Q: How many participants are currently included in this research endeavor?

Affirmative, clinicaltrials.gov verifies that this trial is currently seeking participants. The study was first published on April 19th 2022 and has recently been edited on October 28th 2022. 30 individuals are required from 1 medical centre for the experiment to commence.

Phase < 1

Waitlist Available

Led By David Turok, MD, MPH

Research Sponsored by University of Utah

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Aged 18 years or older

Speak English or Spanish

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within 7 days of initiating atorvastatin (80 mg per day)

Awards & highlights

Study Summary

This trialis testing if a new type of pill can end a pregnancy. Participants take a pill at the clinic, and then take it daily for 6 more days, then return to the clinic and take another pill. Follow-up visits include an ultrasound to check if the abortion was successful.

Who is the study for?

This trial is for adults over 18 who are up to 49 days pregnant and want an abortion. They must speak English or Spanish, be able to follow the study plan, and agree to possibly delay their abortion by 1-2 weeks. People can't join if they're over this pregnancy stage, have certain medical conditions, use conflicting drugs, can't return for follow-ups, are breastfeeding or already on similar medications.Check my eligibility

What is being tested?

The study tests if atorvastatin followed by misoprostol can end a pregnancy. Participants will take atorvastatin orally for seven days and then misoprostol on the eighth day in the clinic. Their progress will be monitored through ultrasounds on approximately days 3, 8 and 11.See study design

What are the potential side effects?

Atorvastatin may cause muscle pain or weakness (myositis), while misoprostol could lead to cramping or bleeding as it induces uterine contractions to terminate the pregnancy.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Select...

I can communicate in English or Spanish.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within 7 days of initiating atorvastatin (80 mg per day)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within 7 days of initiating atorvastatin (80 mg per day)

This trial's timeline: 3 weeks for screening, Varies for treatment, and within 7 days of initiating atorvastatin (80 mg per day) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Interference in pregnancy progress

Trial Design

1Treatment groups

Experimental Treatment

Group I: Experimental: Atorvastatin followed by misoprostolExperimental Treatment2 Interventions

Oral dose of atorvastatin (80 mg) to be taken daily for seven days followed by misoprostol (800 mcg) on day 8. A second dose of misoprostol will occur 24 hours after the first dose if no significant bleeding (more than a regular period) has occurred.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Atorvastatin

1998

Completed Phase 4

~10900

Misoprostol

2008

Completed Phase 4

~3340

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of UtahLead Sponsor

1,098 Previous Clinical Trials

1,778,621 Total Patients Enrolled

Grand Challenges CanadaOTHER

62 Previous Clinical Trials

95,657 Total Patients Enrolled

David Turok, MD, MPHPrincipal InvestigatorUniversity of Utah

4 Previous Clinical Trials

3,088 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment accommodating elderly individuals?

"Eligibility for this study necessitates that participants be aged 18 or older, and under 50 years of age."

Answered by AI

Is the recruitment for this clinical experiment still open?

"Per the details on clinicaltrials.gov, this research is currently enrolling participants. It was initially posted in April of 2022 and its data was most recently updated at the end of October that same year."

Answered by AI

What type of participants are most suitable for this research?

"This clinical trial seeks 30 individuals aged between 18 and 50 who have experienced an early abortion. The prospective participants must be able to speak English or Spanish, willing to postpone their termination of pregnancy by up to two weeks, abstain from contraception until the completion of their abortion procedure, comply with all protocol requirements, and accept that they may require a uterine aspiration in order for the study regimen to successfully terminate their pregnancy."

Answered by AI

How many participants are currently included in this research endeavor?

"Affirmative, clinicaltrials.gov verifies that this trial is currently seeking participants. The study was first published on April 19th 2022 and has recently been edited on October 28th 2022. 30 individuals are required from 1 medical centre for the experiment to commence."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy

2022. "Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05342974.

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