Radiation Therapy for Metastatic Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to find out whether lattice radiation therapy (LRT) is an effective radiation therapy technique when compared to standard stereotactic body radiation therapy (SBRT). The study will also study how the different radiation therapy techniques (LRT and SBRT) affect how many immune cells are able to attack and kill tumor cells (immune infiltration).
Will I have to stop taking my current medications?
You may need to stop taking certain medications. If you are on high doses of steroids, you must stop them during the study. Also, any cancer treatments should be paused for a few days before and after the radiation therapy.
Is stereotactic ablative radiotherapy (SABR) generally safe for humans?
Stereotactic ablative radiotherapy (SABR) is generally considered safe for treating various cancers, but it can cause serious complications, especially if not carefully planned and guided. Studies have shown it to be a safe option for liver and lung tumors, but there are risks of toxic effects, including potential damage to nearby organs.12345
How is Lattice Radiation Therapy different from other treatments for metastatic cancer?
Lattice Radiation Therapy (LRT) is unique because it combines high doses of radiation delivered precisely to cancerous areas, similar to Stereotactic Body Radiation Therapy (SBRT), which is already used for early-stage lung cancer and other conditions. This precise targeting allows for effective treatment of tumors while minimizing damage to surrounding healthy tissue, making it a promising option for patients with metastatic cancer.46789
What data supports the effectiveness of the treatment Lattice Radiation Therapy (LRT) and Stereotactic Ablative Radiotherapy (SABR) for metastatic cancer?
Research shows that Stereotactic Ablative Radiotherapy (SABR) is effective in treating early-stage non-small cell lung cancer and pulmonary metastases, improving tumor control and overall survival. This suggests that SABR, a component of Lattice Radiation Therapy, may also be beneficial for metastatic cancer.4781011
Who Is on the Research Team?
Atif Khan, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults with advanced solid tumors needing palliative radiation, who have at least one other site of metastasis suitable for radiation. They must be in good physical condition (ECOG 0 or 1) and understand the study's risks. It's not for those previously radiated at the same sites, with uncontrolled conditions like infections or diabetes, on steroids, pregnant/breastfeeding, having a second active cancer, or unable to follow study procedures.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive lattice radiation therapy (LRT) or standard stereotactic body radiation therapy (SBRT) to treat metastatic solid tumors
Follow-up
Participants are monitored for safety and effectiveness after radiation therapy, with a focus on immune cell infiltration and overall response rate
What Are the Treatments Tested in This Trial?
Interventions
- Lattice Radiation Therapy
- Stereotactic body radiotherapy
- Stereotactic Body Radiotherapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
Varian Medical Systems
Industry Sponsor
Dow R. Wilson
Varian Medical Systems
Chief Executive Officer since 2012
MBA from Dartmouth's Amos Tuck School of Business, BA from Brigham Young University
Dr. Deepak Khuntia
Varian Medical Systems
Chief Medical Officer since 2020
MD from the University of Cambridge, PhD from the University of Leicester