30 Participants Needed

Molecular Imaging with MRI for Brain Cancer

NP
Overseen ByNathalie Padron
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Miami
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

MRI-based sequences can provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

Is the 3T MRI scanner safe for use in humans?

The 3T MRI scanner is generally considered safe for use in humans, as it is a standard clinical tool used for various imaging purposes, including brain imaging. While the studies provided focus on animal models, the use of clinical MRI scanners in these studies suggests a level of safety and reliability that is typically required for human use.12345

How is the 3T MRI Scanner treatment unique for brain cancer?

The 3T MRI Scanner is unique for brain cancer because it not only provides detailed anatomical images but also allows for molecular imaging, which can detect molecular changes in the brain before they become visible as structural changes. This advanced imaging capability helps in better understanding and monitoring the cancer, potentially leading to more personalized treatment strategies.678910

What data supports the effectiveness of the treatment 3T MRI Scanner for brain cancer?

Research shows that advanced MRI, like the 3T MRI Scanner, can help doctors make personalized treatment decisions for brain cancer by providing detailed images of tumors and their blood supply. This technology can also guide and monitor cancer therapies, potentially improving outcomes.410111213

Who Is on the Research Team?

MD

Macarena De La Fuente, MD

Principal Investigator

University of Miami

Are You a Good Fit for This Trial?

This trial is for adults over 18 with suspected or confirmed gliomas who are scheduled for a medically indicated brain biopsy or resection. It's not suitable for those unable to consent, minors, pregnant women, or patients who can't undergo MRI scans.

Inclusion Criteria

I am scheduled for a biopsy or surgery to remove a brain lesion.

Exclusion Criteria

I am unable to give consent for myself.
You are unable to have an MRI scan.
Pregnant women

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Imaging

Participants undergo a 3 Tesla (3T) Magnetic Resonance Imaging (MRI) scan of their brain

1 day
1 visit (in-person)

Surgical Procedure

Participants undergo biopsy or resection of their brain tumors for tissue sample collection

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after imaging and surgical procedures

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • 3T MRI Scanner
Trial Overview The study uses a high-tech MRI scanner to non-invasively measure the distribution of a specific molecule (2HG) and cell density in brain tumors. This could help in developing new treatments for gliomas.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: IDH-Mutant Glioma PatientsExperimental Treatment1 Intervention
Patients who have suspected or confirmed gliomas and are scheduled to undergo biopsy or resection of their brain tumors will receive a 3 Tesla (3T) Magnetic Resonance Imaging (MRI) scan of their brain.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Miami

Lead Sponsor

Trials
976
Recruited
423,000+

Published Research Related to This Trial

MRI is a powerful tool in oncology that not only provides detailed anatomical images but also offers functional imaging capabilities to visualize and quantify biochemical processes in tumors.
Recent advancements in MRI technology can enhance the evaluation of cancerous lesions and allow for noninvasive guidance and monitoring of anticancer therapies, potentially improving treatment outcomes.
Cancer imaging: novel concepts in clinical magnetic resonance imaging.Kwee, TC., Takahara, T., Klomp, DW., et al.[2010]
The study developed a targeted imaging strategy using F(ab')2 fragments of an anti-EGFRvIII antibody linked to enzymes, which successfully enhanced MRI signal detection of aggressive brain tumors overexpressing the EGFRvIII variant.
Using SPECT/CT and 3T MRI, the researchers demonstrated that this method allows for high specificity and resolution in imaging tumor-specific receptors, indicating its potential for improved diagnosis and monitoring of brain tumors.
MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model.Shazeeb, MS., Gupta, S., Bogdanov, A.[2021]
The Glioma MR Imaging 2.0 (GliMR) network aims to enhance the use of advanced MRI techniques in glioma treatment, addressing the current limitations in clinical practice and promoting personalized treatment strategies.
Funded by the European Cooperation in Science and Technology, GliMR has initiated several projects to improve glioma imaging, including developing GDPR-compliant consent forms and creating a collaborative platform for experts, with ongoing membership opportunities until September 2023.
GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma.Clement, P., Booth, T., Boroveฤki, F., et al.[2022]

Citations

Cancer imaging: novel concepts in clinical magnetic resonance imaging. [2010]
MR signal amplification for imaging of the mutant EGF receptor in orthotopic human glioma model. [2021]
GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma. [2022]
In Vivo Molecular Profiling of Human Glioma : Cross-Sectional Observational Study Using Dynamic Susceptibility Contrast Magnetic Resonance Perfusion Imaging. [2022]
[Application of ultrahigh-field MRI in neuro-oncology]. [2021]
Analysis of mouse brain using a clinical 1.5 T scanner and a standard small loop surface coil. [2006]
Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform. [2019]
Dynamic contrast-enhanced susceptibility-weighted perfusion MRI (DSC-MRI) in a glioma model of the rat brain using a conventional receive-only surface coil with a inner diameter of 47 mm at a clinical 1.5 T scanner. [2008]
Imaging of experimental rat gliomas using a clinical MR scanner. [2019]
[Magnetic resonance tomography: potentials of molecular imaging]. [2019]
11.United Statespubmed.ncbi.nlm.nih.gov
MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors. [2021]
Magnetic Resonance Imaging and Spectroscopy: Application to Experimental Neuro-Oncology. [2020]
Molecular magnetic resonance imaging in cancer. [2022]
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