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Behavioral Intervention

Enhanced CBT for Depression

N/A
Recruiting
Research Sponsored by Vanderbilt University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after 12 weeks
Awards & highlights

Summary

This trial will test an intervention to improve social cognitive skills in depressed youth, with the goal of making treatment more efficient and effective.

Who is the study for?
This trial is for young people aged 13-17 who are currently dealing with depression. They must have been diagnosed with a depressive disorder or score over 15 on the PHQ9 questionnaire. It's not open to those at immediate risk of suicide, below a 4th-grade reading level, struggling with severe substance abuse, or previously diagnosed with bipolar, schizophrenia, autism, or conduct disorder.Check my eligibility
What is being tested?
The study compares two methods: standard Cognitive Behavioral Therapy (CBT) and CBT enhanced with Social Cognitive Training (CBTSCT), which focuses on improving social understanding like perspective-taking. Participants will be randomly assigned to one of these treatments to see which is more effective in treating depression symptoms and social cognition.See study design
What are the potential side effects?
Since this trial involves therapy sessions rather than medication, there aren't typical side effects like you'd expect from drugs. However, discussing sensitive topics during therapy can sometimes cause discomfort or emotional distress.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and after 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Children's Depression Rating Scale-Revised
Faux Pas Recognition Test

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive behavioral therapy plus social cognitive training (CBTSCT)Experimental Treatment1 Intervention
The cognitive behavioral therapy is based on Beck's cognitive therapy model for the treatment of depression. We will conduct individual therapy with depressed adolescents using modules from the Coping with Stress manual used in other depression treatment studies with adolescents. In addition, therapists will teach teens explicitly about theory of mind and social perspective taking during each session and will use examples from the teen's own life to help them learn the skills.
Group II: Cognitive behavioral therapy (CBT)Active Control1 Intervention
The cognitive behavioral therapy is based on Beck's cognitive therapy model for the treatment of depression. Therapists will conduct individual therapy sessions with depressed adolescents using modules from the Coping with Stress manual. Social cognitive training will not be provided to teens in this condition.

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Who is running the clinical trial?

Vanderbilt UniversityLead Sponsor
707 Previous Clinical Trials
6,143,451 Total Patients Enrolled
29 Trials studying Depression
6,184 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,820 Previous Clinical Trials
2,692,737 Total Patients Enrolled
675 Trials studying Depression
256,807 Patients Enrolled for Depression

Media Library

Depression Research Study Groups: Cognitive behavioral therapy plus social cognitive training (CBTSCT), Cognitive behavioral therapy (CBT)
~35 spots leftby Dec 2025
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