Saxenda for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this protocol is to investigate the effect of treatment with the study drug Liraglutide, a GLP-1 receptor agonist, on centers of the brain that control appetite and food intake.
Will I have to stop taking my current medications?
The trial requires that you stay on the same medication and dose throughout the study. If you are taking medications like warfarin, steroids, or certain hormones, you may not be eligible to participate.
Is Saxenda (liraglutide) safe for humans?
What makes the drug Saxenda unique for treating obesity?
What data supports the effectiveness of the drug Saxenda for obesity?
Are You a Good Fit for This Trial?
This trial is for adults with obesity (BMI >30 or >27 with related health issues like high blood pressure). It's not for those who are pregnant, breastfeeding, planning to get pregnant, have severe kidney or liver problems, heart failure, certain mental health conditions, uncontrolled infections like HIV/hepatitis, history of pancreatitis or thyroid disease. People with metal implants that affect MRI scans or weigh over 330lbs can't join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive liraglutide with dose titration over 5 weeks followed by a minimum of 3 weeks wash-out, then placebo for the same duration, or vice versa.
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Liraglutide
- Placebo
Liraglutide is already approved in United States, European Union for the following indications:
- Type 2 diabetes mellitus treatment
- Cardiovascular risk reduction in adults with type 2 diabetes and heart disease
- Weight loss treatment in adults and children aged 12 and older with obesity
- Type 2 diabetes mellitus treatment
- Cardiovascular risk reduction in adults with type 2 diabetes and heart disease
- Weight loss treatment in adults and children aged 12 and older with obesity
Find a Clinic Near You
Who Is Running the Clinical Trial?
Beth Israel Deaconess Medical Center
Lead Sponsor