Glucose Metabolism Tracer for Metabolism
(TORCH Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how immune cells use glucose, a common sugar, to produce energy and build new cell parts. Participants will receive a special glucose tracer, 13C6-Glucose, through an IV to observe how their immune cells take up and use this sugar. Suitable candidates have stable blood sugar levels and are not currently participating in any other study involving large blood draws. As an unphased trial, this study offers a unique opportunity to contribute to foundational research that could lead to new insights in immune cell metabolism.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. It might depend on whether your medications could interfere with the study, so it's best to discuss this with the study investigator.
What prior data suggests that this glucose tracer is safe?
Research has shown that 13C6-Glucose is usually safe at the doses used in studies. Safety data indicate it does not irritate the skin or eyes if handled correctly. However, swallowing it might cause minor harm, and if it contacts the skin, washing with soap and water is advised. The evidence does not show any major side effects, suggesting it is safe when used as intended in clinical settings.12345
Why are researchers excited about this trial?
Unlike the standard treatments for metabolic disorders, which typically focus on managing symptoms through medications and lifestyle changes, the 13C6-Glucose tracer offers a unique approach by directly tracking glucose metabolism in the body. Researchers are excited about this treatment because it uses a labeled glucose molecule, which allows for precise monitoring of how glucose is processed. This could lead to a better understanding of metabolic conditions and the development of more targeted therapies. By providing real-time insights into glucose utilization, 13C6-Glucose could revolutionize how we diagnose and treat metabolic disorders.
What evidence suggests that this tracer is effective for studying glucose metabolism?
Research has shown that 13C6-glucose, which participants in this trial will receive, effectively tracks how cells use glucose, especially under conditions like low oxygen levels. Studies have demonstrated that it helps trace glucose through key processes, such as glycolysis (where glucose breaks down for energy) and the pentose phosphate pathway (which supports cell growth). This tracer allows scientists to observe how cells use glucose for energy and building materials. While primarily used to understand glucose processing in the body, evidence supports its effectiveness in providing clear insights into cellular energy management.678910
Who Is on the Research Team?
Matthew T Stier, M.D., Ph.D.
Principal Investigator
Vanderbilt University Medical Center
Are You a Good Fit for This Trial?
This trial is for adults over 18 who want to help understand how immune cells use sugar. It's not for pregnant individuals, prisoners, those in another high-volume blood draw study, or anyone with uncontrolled diabetes or other conditions that could interfere with the study.Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Intravenous infusion of a non-radioactive glucose tracer into participants over a few hours
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- 13C6-Glucose
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vanderbilt University Medical Center
Lead Sponsor