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Cediranib + Olaparib vs Bevacizumab for Recurrent Glioblastoma
Study Summary
This trial is comparing the effectiveness of cediranib maleate and olaparib vs bevacizumab in treating patients with recurrent glioblastoma.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- I have not had an abdominal abscess in the last 6 months.I have never had pneumonitis.My GBM has recurred no more than twice.I have been diagnosed with myelodysplastic syndrome or acute myeloid leukemia.I have never had a hypertensive crisis or brain issues due to high blood pressure.I have early-stage breast or cervical cancer.I have unstable chest pain.I do not have any serious illnesses that are not under control.I have not used PARP inhibitors or drugs affecting the VEGF pathway.It's been over 12 weeks since my last radiotherapy, or my cancer has grown outside the treated area if it's been less.You are expected to live for at least 3 more months.I have serious blood vessel problems in my arms or legs.My heart's electrical activity is normal and I have no family history of long QT syndrome.I am not pregnant, not breastfeeding, and willing to use birth control during the study.I have moderate to severe heart failure.My blood pressure is controlled and I take 3 or fewer medications for it.I have not had any abdominal openings or gut tears in the last 6 months.I have a serious blood vessel condition like an aortic aneurysm.My heart's pumping ability is normal or above 55%.I am not pregnant or breastfeeding.I am willing to provide my previous biopsy samples for research.My kidney function tests are within normal range.I haven't had major surgery or significant injury in the last 28 days and don't expect to need any during the study.I am not taking strong or moderate CYP3A4 inhibitors or inducers.My corticosteroid dose has been stable or decreasing for the last 5 days.I have no other cancers besides the one being treated.My brain scans show my tumor is growing, or I have a confirmed recurrent glioblastoma.I can care for myself but may need occasional help.I have had a stroke in the last 6 months.My hemoglobin is at least 10.0 g/dL and I haven't had a blood transfusion in the last 28 days.I had a heart attack in the last six months.I have waited the required time after my last cancer treatment to start a new one.I had cancer before, treated to cure, with no signs of it coming back for 3 years.All my side effects from previous treatments are gone, except maybe for hair loss.I have been treated with radiotherapy and temozolomide before.You cannot be taking any other experimental drugs or treatments.I haven't had symptoms of bowel obstruction in the last 3 months.You have had allergic reactions to medications similar to olaparib, cediranib, or bevacizumab in the past.People who have any of the following:I have been treated for early-stage skin cancer.
- Group 1: Arm A (olaparib, cediranib maleate)
- Group 2: Arm B (bevacizumab)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are Bevacizumab's most common applications?
"Bevacizumab is commonly used to treat recurrent platinum-resistant epithelial ovarian cancer. However, this medication can also be helpful for patients with malignant neoplasms, recurrent platinum sensitive primary peritoneal cancer, and locally advanced nonsquamous non-small cell lung cancer."
What other data exists for Bevacizumab?
"At the moment, 565 clinical trials are underway to study Bevacizumab. Of these ongoing studies, 123 have reached Phase 3 status. Many of the Bevacizumab trials are based in Taibei, Taiwan; however, there are a total of 27564 locations worldwide where patients can participate in this research."
Can people still sign up for this clinical trial?
"No, this trial is not currently active as indicated on clinicaltrials.gov. The last time this study recruited patients was in September of 2017; however, there are 2009 other trials that are actively recruiting right now."
Could you please tell me how many hospitals are part of this experiment?
"This clinical trial is recruiting patients from 27 different locations, including Smilow Cancer Hospital-Derby Care Center in Derby, University of Colorado Hospital in Aurora, and Smilow Cancer Hospital Care Center at Saint Francis in Hartford."
Are there negative side effects associated with Bevacizumab?
"There is some evidence to support the safety of Bevacizumab, but not its efficacy, so it received a score of 2."
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