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Diagnostic Coronary Angiography with Non-Obstructive CAD for Coronary Microvascular Disease

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Coronary Microvascular Disease+2 MoreDiagnostic Coronary Angiography with Non-Obstructive CAD - DiagnosticTest
Eligibility
18 - 125
All Sexes
What conditions do you have?
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Study Summary

This trial will look at women with stable heart disease who don't have blockages in their coronary arteries. A substantial proportion of these patients have ischemia (reduced blood flow) based on symptoms or stress testing. This may be due to microvascular dysfunction, which is an abnormal function of the tiny arteries in the heart. The mechanisms and optimal treatment of coronary microvascular dysfunction are unknown. This trial will evaluate the association between platelet activity, inflammation, and microvascular dysfunction.

Eligible Conditions
  • Coronary Microvascular Disease
  • Coronary Artery Disease
  • Myocardial Ischemia

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Remote ischemic preconditioning
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Medium ACT Target
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post-PCI FFR

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: 12 Months

12 Months
Measure of Inflammation measured by the Index of Microcirculatory Resistance (IMR)
Platelet Activity measured by the Index of Microcirculatory Resistance (IMR)

Trial Safety

Safety Progress

1 of 3

Similar Trials

2
Remote ischemic preconditioning
2
Medium ACT Target
1
post-PCI FFR

Trial Design

1 Treatment Group

Non-Obstructive CAD
1 of 1

Experimental Treatment

100 Total Participants · 1 Treatment Group

Primary Treatment: Diagnostic Coronary Angiography with Non-Obstructive CAD · No Placebo Group · N/A

Non-Obstructive CAD
DiagnosticTest
Experimental Group · 1 Intervention: Diagnostic Coronary Angiography with Non-Obstructive CAD · Intervention Types: DiagnosticTest

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,264 Previous Clinical Trials
753,491 Total Patients Enrolled
Nathaniel Smilowitz, MDPrincipal InvestigatorNYU Langone Health
1 Previous Clinical Trials
100 Total Patients Enrolled

Eligibility Criteria

Age 18 - 125 · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
The text is about adult women who are referred for a coronary angiography
, is associated with a significantly increased risk of death and/or MI, even after adjustment for other risk factors
References

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