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Circulation Evaluation Techniques for Sepsis (DAISY Trial)

N/A

Recruiting

Research Sponsored by Denver Health and Hospital Authority

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 90 day

Awards & highlights

DAISY Trial Summary

This trial aims to understand how eGC breakdown can influence HI to help develop better resuscitation treatments. HVM & biomarkers will be used to serially evaluate MiH & eGC.

Who is the study for?

This trial is for adults diagnosed with sepsis or septic shock who need to be admitted to the hospital. It also includes a control group of adults undergoing elective surgery that requires intubation and general anesthesia.Check my eligibility

What is being tested?

The study aims to understand how well handheld vital microscopy can predict outcomes in patients by looking at tiny blood vessels under the tongue and measuring substances in the urine that indicate blood vessel health.See study design

What are the potential side effects?

Since this trial involves non-invasive monitoring techniques like ultrasound, passive leg raises, and sublingual microscopy, side effects are minimal but may include discomfort from the procedures.

DAISY Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 90 day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~90 day

This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Initiation and Duration Renal Replacement Therapy

Secondary outcome measures

Rate of 90 day survival

Rate of Inpatient Mortality

DAISY Trial Design

2Treatment groups

Experimental Treatment

Group I: Septic Patient InterventionsExperimental Treatment4 Interventions

Septic Patients will have all interventions performed: Urine collection, Passive Leg Raise, Ultrasound and sublingual microscopy

Group II: Control Patient InterventionsExperimental Treatment2 Interventions

Control patients will have urine collection and sublingual microscopy performed when intubated

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Institutes of Health (NIH)NIH

2,701 Previous Clinical Trials

7,506,700 Total Patients Enrolled

13 Trials studying Sepsis

9,594 Patients Enrolled for Sepsis

Denver Health and Hospital AuthorityLead Sponsor

101 Previous Clinical Trials

400,247 Total Patients Enrolled

1 Trials studying Sepsis

57 Patients Enrolled for Sepsis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the minimum age criteria for participants of this trial younger than 50 years?

"This experiment is only accepting participants aged between 18 and 99. In contrast, there are 37 trials for minors and 191 studies catering to elderly patients."

Answered by AI

Is this research endeavor open to new participants?

"According to clinicaltrials.gov, this medical trial is still actively recruiting participants. The protocol was initially announced on July 1st 2022 and the details were most recently modified on January 13th 2023."

Answered by AI

Is there a limit to the number of volunteers participating in this clinical trial?

"Confirmed. According to the information on clinicaltrials.gov, this research project is actively recruiting participants since its initial posting on July 1st 2022 and final update from January 13th 2023. A total of 150 patients are sought after by a single medical site."

Answered by AI

Is participation in this trial open to the public?

"To qualify for this medical trial, potential participants must be between 18 and 99 years of age with a diagnosis of septic shock. A total of 150 persons are expected to take part in the study."

Answered by AI

Who else is applying?

What site did they apply to?

Denver Health Medical Center

What portion of applicants met pre-screening criteria?

Met criteria

Why did patients apply to this trial?

sepsis 2yrs ago right after surgery, within a few hrs. It's played havoc on my immune system. The 1st 2yrs I was in-out of the hospital. One stay was for almost 2wks. I want to know if this germ is with me for life. Lately I've been getting sick, totally in bed with body hurts and pain is this what I can expect.

PatientReceived 1 prior treatment

Recent research and studies

clinicaltrials.govStudy

Micro and Macro Circulation in Sepsis

Ivor Douglas 2022. "Micro and Macro Circulation in Sepsis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05694455.

All > Sepsis