Metformin (Bed Rest) for Insulin Resistance

University of Utah, Salt Lake City, UT
Insulin Resistance+1 More ConditionsMetformin (Bed Rest) - Drug
Eligibility
18+
All Sexes

Study Summary

This trial investigates whether metformin can help prevent muscle loss and insulin resistance in healthy older adults who are bedridden.

Eligible Conditions
  • Insulin Resistance
  • Muscle Wasting

Treatment Effectiveness

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: Change in insulin sensitivity from baseline to 5-days of bed rest will be compared between groups after 5 days of bed rest

Day 5
Insulin sensitivity
Day 5
Muscle size

Trial Safety

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 20 Other Conditions
This treatment demonstrated efficacy for 20 other conditions.

Trial Design

4 Treatment Groups

Metformin (Bed Rest)
1 of 4
Metformin (2 week run-in only)
1 of 4
Placebo (Bed Rest)
1 of 4
Placebo (2 week run-in only)
1 of 4

Experimental Treatment

Non-Treatment Group

64 Total Participants · 4 Treatment Groups

Primary Treatment: Metformin (Bed Rest) · Has Placebo Group · Phase < 1

Metformin (Bed Rest)
Drug
Experimental Group · 1 Intervention: Metformin (Bed Rest) · Intervention Types: Drug
Metformin (2 week run-in only)
Drug
Experimental Group · 1 Intervention: Metformin (2 week run-in only) · Intervention Types: Drug
Placebo (Bed Rest)
Drug
PlaceboComparator Group · 1 Intervention: Placebo (Bed Rest) · Intervention Types: Drug
Placebo (2 week run-in only)
Drug
PlaceboComparator Group · 1 Intervention: Placebo (2 week run-in only) · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: change in insulin sensitivity from baseline to 5-days of bed rest will be compared between groups after 5 days of bed rest

Who is running the clinical trial?

University of UtahLead Sponsor
1,022 Previous Clinical Trials
1,776,311 Total Patients Enrolled
2 Trials studying Insulin Resistance
58 Patients Enrolled for Insulin Resistance
Micah DrummondPrincipal Investigator - University of Utah
University of Utah
3 Previous Clinical Trials
91 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 0 Total Inclusion Criteria

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Frequently Asked Questions

How many volunteers are enrolled in this clinical research?

"Affirmative. Data sourced from clinicaltrials.gov displays that this medical trial, which was first advertised on August 1st 2019, is still seeking out participants. The research team needs to enroll around 60 individuals across one site." - Anonymous Online Contributor

Unverified Answer

Are there any other trials that have been conducted for the purpose of determining Metformin's efficacy in combination with Bed Rest?

"Currently, the use of Metformin (Bed Rest) is being studied in 170 active clinical trials, 43 of which are presently at Phase 3. Although Pittsburgh, Pennsylvania has several studies examining its effects on patients, there are 1903 other medical sites running these tests." - Anonymous Online Contributor

Unverified Answer

In what cases is Metformin (Bed Rest) usually prescribed?

"Metformin (Bed Rest) is prescribed to treat exercise-induced complications, as well as type 1 diabetes mellitus, diabetic ketoacidosis and polycystic ovary syndrome." - Anonymous Online Contributor

Unverified Answer

Are there any open slots available in this research program?

"Affirmative. Information available on clinicaltrials.gov affirms that this research study is actively recruiting participants, having been initially posted on the 1st of August 2019 and last updated on 17th June 2022. The trial seeks 60 volunteers to be recruited from one site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.