Metformin for Muscle Health in Older Adults
What You Need to Know Before You Apply
What is the purpose of this trial?
Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the mechanisms are not fully known. Metformin used as a preventive strategy to maintain muscle and metabolic health in bed ridden older adults has not been investigated.
Do I need to stop my current medications to join the trial?
The trial does not specify if you need to stop all current medications, but you cannot participate if you are using anticoagulant therapy or chronic systemic corticosteroids. It's best to discuss your specific medications with the trial team.
Is metformin generally safe for humans?
How does the drug metformin differ from other treatments for muscle health in older adults?
Metformin is unique because it is traditionally used as an antidiabetic drug but is being explored for its potential to improve muscle health in older adults by enhancing muscle response to resistance training and preventing muscle damage from inactivity. Unlike other treatments, metformin may also influence muscle tissue inflammation and promote healthy aging.16789
What data supports the effectiveness of the drug metformin for muscle health in older adults?
Research suggests that short-term metformin use in older adults can improve the function of muscle progenitor cells, which are important for muscle repair and growth. Additionally, metformin may enhance the response to resistance exercise training by altering the muscle's inflammatory environment, potentially improving muscle mass and strength.148910
Who Is on the Research Team?
Micah Drummond
Principal Investigator
University of Utah
Are You a Good Fit for This Trial?
This trial is for healthy older adults aged 60 and above who can consent to participate. They must not have serious health issues like uncontrolled diseases, recent cancer (except basal cell carcinoma), kidney or liver disease, respiratory problems, cardiovascular conditions, or be on certain medications like anticoagulants.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Metformin Run-in
Participants receive metformin incrementally to reach a clinical dose of 2 grams per day over a 2-week period
Bed Rest
Participants undergo 5 days of bed rest while receiving metformin or placebo to assess changes in insulin sensitivity and muscle size
Recovery
Participants are monitored for recovery of muscle size, strength, and insulin sensitivity after bed rest
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Metformin
- Placebo
Metformin is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor