Study Summary
This trial investigates whether metformin can help prevent muscle loss and insulin resistance in healthy older adults who are bedridden.
- Insulin Resistance
- Muscle Wasting
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
2 Primary · 0 Secondary · Reporting Duration: Change in insulin sensitivity from baseline to 5-days of bed rest will be compared between groups after 5 days of bed rest
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
4 Treatment Groups
Metformin (Bed Rest)
1 of 4
Metformin (2 week run-in only)
1 of 4
Placebo (Bed Rest)
1 of 4
Placebo (2 week run-in only)
1 of 4
Experimental Treatment
Non-Treatment Group
64 Total Participants · 4 Treatment Groups
Primary Treatment: Metformin (Bed Rest) · Has Placebo Group · Phase < 1
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- McKenzie, Alec I., Ziad S. Mahmassani, Jonathan J. Petrocelli, Naomi M.M.P. de Hart, Dennis K. Fix, Patrick J. Ferrara, Paul C. LaStayo, et al.. 2022. “Short-term Exposure to a Clinical Dose of Metformin Increases Skeletal Muscle Mitochondrial H2O2 Emission and Production in Healthy, Older Adults: A Randomized Controlled Trial”. Experimental Gerontology. Elsevier BV. doi:10.1016/j.exger.2022.111804.
- McKenzie, Alec I., Ziad S. Mahmassani, Jonathan J. Petrocelli, Naomi M.M.P. de Hart, Dennis K. Fix, Patrick J. Ferrara, Paul C. LaStayo, et al.. 2022. “Short-term Exposure to a Clinical Dose of Metformin Increases Skeletal Muscle Mitochondrial H2O2 Emission and Production in Healthy, Older Adults: A Randomized Controlled Trial”. Experimental Gerontology. Elsevier BV. doi:10.1016/j.exger.2022.111804.
- McKenzie AI, Mahmassani ZS, Petrocelli JJ, de Hart NMMP, Fix DK, Ferrara PJ, LaStayo PC, Marcus RL, Rondina MT, Summers SA, Johnson JM, Trinity JD, Funai K, Drummond MJ. Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial. Exp Gerontol. 2022 Jun 15;163:111804. doi: 10.1016/j.exger.2022.111804. Epub 2022 Apr 9.
- Micah Drummond 2019. "Role of Metformin on Muscle Health of Older Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03107884.
Frequently Asked Questions
How many volunteers are enrolled in this clinical research?
"Affirmative. Data sourced from clinicaltrials.gov displays that this medical trial, which was first advertised on August 1st 2019, is still seeking out participants. The research team needs to enroll around 60 individuals across one site." - Anonymous Online Contributor
Are there any other trials that have been conducted for the purpose of determining Metformin's efficacy in combination with Bed Rest?
"Currently, the use of Metformin (Bed Rest) is being studied in 170 active clinical trials, 43 of which are presently at Phase 3. Although Pittsburgh, Pennsylvania has several studies examining its effects on patients, there are 1903 other medical sites running these tests." - Anonymous Online Contributor
In what cases is Metformin (Bed Rest) usually prescribed?
"Metformin (Bed Rest) is prescribed to treat exercise-induced complications, as well as type 1 diabetes mellitus, diabetic ketoacidosis and polycystic ovary syndrome." - Anonymous Online Contributor
Are there any open slots available in this research program?
"Affirmative. Information available on clinicaltrials.gov affirms that this research study is actively recruiting participants, having been initially posted on the 1st of August 2019 and last updated on 17th June 2022. The trial seeks 60 volunteers to be recruited from one site." - Anonymous Online Contributor