Stereotactic Radiotherapy for Lung Cancer

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Lung CancerStereotactic Radiotherapy - Radiation
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether surgery or stereotactic radiotherapy is better for people with stage I non-small cell lung cancer.

Eligible Conditions
  • Lung Cancer

Treatment Effectiveness

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: From date of randomization through study completion, up to 10 years

5 years
Health State Utilities
Patient reported health-related quality of life
Respiratory Function
Tumor patterns of failure
Year 10
Overall Survival
Year 10
Lung cancer mortality

Trial Safety

Trial Design

2 Treatment Groups

Surgery
1 of 2
Stereotactic radiotherapy
1 of 2

Active Control

Experimental Treatment

670 Total Participants · 2 Treatment Groups

Primary Treatment: Stereotactic Radiotherapy · No Placebo Group · N/A

Stereotactic radiotherapy
Radiation
Experimental Group · 1 Intervention: Stereotactic Radiotherapy · Intervention Types: Radiation
Surgery
Procedure
ActiveComparator Group · 1 Intervention: Anatomic Pulmonary Resection · Intervention Types: Procedure
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stereotactic Radiotherapy
2018
N/A
~40

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: from date of randomization through study completion, up to 10 years

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,485 Previous Clinical Trials
2,741,549 Total Patients Enrolled
David H Harpole, MDStudy ChairDurham VA Medical Center, Durham, NC
Drew Moghanaki, MD MPHStudy ChairVA Greater Los Angeles Healthcare System, West Los Angeles, CA

Eligibility Criteria

Age 18+ · All Participants · 10 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a Karnofsky performance status of 70 or greater.
Tumor size less than or equal to 5 cm.