Zoledronic Acid for Anterior Cruciate Ligament Injury
(ZAPOA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.
Who Is on the Research Team?
Steven Boyd, PhD
Principal Investigator
University of Calgary
Gregory Kline, MD
Principal Investigator
University of Calgary
Are You a Good Fit for This Trial?
This trial is for adults with a recent, complete tear in their anterior cruciate ligament (ACL) who have normal calcium and kidney function. They can have other knee injuries too but shouldn't be pregnant or planning pregnancy soon, have past knee injuries, or conditions affecting bone turnover.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a zoledronic acid injection at baseline
Monitoring
Participants are monitored radiographically with HR-pQCT, DECT, X-Ray, EOS, and MRI to assess joint changes and effects of zoledronic acid
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Placebo
- Zoledronic Acid Injection
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Calgary
Lead Sponsor