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Pazopanib for Carcinoid Tumor
Study Summary
This trial is testing how well pazopanib hydrochloride works in treating patients with carcinoid tumors. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2016 Phase 2 trial • 22 Patients • NCT01247571Trial Design
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- I have symptoms of poor blood flow in my limbs.Your heart's pumping ability is strong (ejection fraction > 50%).My blood clotting time is slightly higher due to my anticoagulant medication.Your bilirubin levels are higher than 1.5 times the normal limit.I am 18 years old or older.My scans show my cancer has worsened in the last year.You have a detectable disease that can be seen on a CT scan or MRI according to specific guidelines.I have never been treated with drugs that target VEGF or VEGFR.You have evidence of cancer spreading to the brain at the start of the study.Your heart takes too long to recharge between beats.Your blood test shows creatinine levels higher than 1.5 times the normal range.Your urine protein level is too high.My cancer is a low or intermediate-grade neuroendocrine type, not high-grade or poorly differentiated.Your blood creatinine level is not higher than 1.5 times the upper limit of normal.My cancer has spread to the large blood vessels of my lungs.I have large growths in the main airways of my lungs.I have a condition that weakens my immune system.I have a carcinoid tumor not suspected to be specific excluded types, with or without symptoms, and it has worsened after PRRT treatment completed over 8 weeks ago.My lung cancer does not involve major blood vessels or large airways.Your platelet count is at least 100,000 per microliter.I have a confirmed carcinoid tumor.Your AST and ALT blood test results must be less than or equal to 2.5 times the upper limit of normal.Your urine protein level is less than a certain amount.My blood clotting test results are within the normal range, even though I'm on blood thinners.My cancer has not spread to my brain or spinal cord.My cancer can be measured by scans and is at least 1 cm in size.I haven't had any cancer except for skin cancer in the last 5 years.My lung cancer affects the airways or blood vessels in my lungs.I haven't had serious wounds, ulcers, injuries, or broken bones in the last 28 days.My cancer has worsened in the last year, even with treatment.I have had a condition where my lymphocytes grow abnormally.I haven't had major stomach or intestine issues in the last 28 days.I have had symptoms of heart failure in the last 6 months.I am not on any strong CYP3A4 inhibitors.My cancer cannot be removed by surgery and may have spread.I haven't had serious wounds, ulcers, injuries, or broken bones in the last 28 days.I have not had heart failure symptoms in the last 6 months.I do not have irregular heartbeats or prolonged QTc.I stopped taking strong CYP3A4 inhibitors 2 weeks before starting the study treatment.I have not had a clot in my arteries in the last 6 months.I do not have unstable heart pain or uncontrolled irregular heartbeats.My cancer is a low- or intermediate-grade neuroendocrine type.I have been on a stable blood thinner for at least 6 weeks.I haven't had any unusual bleeding or coughing up blood in the last 8 weeks.I do not have unstable heart pain or uncontrolled irregular heartbeats.Your thyroid-stimulating hormone (TSH) levels are normal.I have a history of cancer.My cancer is a specific type of aggressive neuroendocrine tumor.Your AST and ALT levels in your blood are more than 2.5 times higher than the upper limit of normal.I haven't had a clot in my arteries in the last 6 months.I haven't had any major abdominal issues like a fistula, perforation, or abscess in the last month.I have not had any major abdominal issues like a fistula, perforation, or abscess in the last 28 days.Your heart's pumping ability is less than 50% according to a specific heart test.Your thyroid-stimulating hormone (TSH) levels are not in the normal range.I have completed all required surgeries within the specified time.I haven't had serious stomach or intestine problems in the last month.You have a healthy amount of a type of white blood cell called granulocytes.I am not pregnant.My blood pressure is under control.I am fully active or can carry out light work.You have a low number of granulocytes in your blood.Your platelet count is less than 100,000 per microliter.Your heart's electrical activity should be within a certain range (less than or equal to 480 milliseconds).Your bilirubin level must be less than or equal to 1.5 times the upper limit of normal.
- Group 1: Arm II (placebo)
- Group 2: Arm I (pazopanib hydrochloride)
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is the recruitment period still open for this research trial?
"At the moment, this trial is not open for recruitment. Initially posted on June 21st 2013 and last edited on September 23rd 2022, any hopeful participants should look to 3502 other studies enrolling cancer patients or 24 trials that use Pazopanib Hydrochloride as an intervention."
What is the total capacity of this medical trial?
"At the current moment, this research project is not seeking any additional volunteers. The first posting of said study was on June 21st 2013 and it has since been updated last September 23rd 2022. If you are looking for other clinical trials to take part in, there are 3502 cancer studies currently enrolling participants and 24 active investigations that involve Pazopanib Hydrochloride."
Does this trial feature a novel approach or strategy?
"Since 2011, Pazopanib Hydrochloride has been under investigation. The initial trial was sponsored by Novartis in 2011 and included 180 participants. Following this first study, the drug achieved its Phase 2 approval for use. Currently there are 24 active studies within 23 countries across 608 cities involving this medication."
What is the geographical extent of this experimental research?
"At the moment, this study is recruiting patients from a total of 100 centres. These are mostly located in Kansas City, Saint Joseph and Milwaukee but there are also other sites that potential participants can attend. To reduce transportation needs, it would be prudent to select a clinic closest you."
Are there any previous trials that have examined the efficacy of Pazopanib Hydrochloride?
"Pazopanib Hydrochloride has had a long history of clinical research, beginning at the University of Texas MD Anderson Cancer Center in 2011. 807 trials have successfully concluded to date and there are presently 24 active studies underway, with many taking place around Kansas City, Kansas."
What potential risks can individuals incur from taking Pazopanib Hydrochloride?
"Given the lack of efficacy data, but presence of safety data, our team at Power awarded Pazopanib Hydrochloride a score of 2 on our 1 to 3 scale."
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