Bicruciate-retaining vs Posterior-stabilized Knee Replacement for Osteoarthritis
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Bicruciate-retaining Total Knee Arthroplasty and Posterior-stabilized Total Knee Arthroplasty for osteoarthritis?
Research comparing different types of knee replacements, like posterior-stabilized and cruciate-retaining, shows mixed results in terms of knee function and complications. However, these studies suggest that both types of knee replacements can be effective, with differences in outcomes like knee movement and stability.12345
Is the bicruciate-retaining or posterior-stabilized knee replacement safe for humans?
How does bicruciate-retaining total knee arthroplasty differ from other treatments for osteoarthritis?
Bicruciate-retaining total knee arthroplasty is unique because it aims to preserve both the anterior and posterior cruciate ligaments in the knee, potentially offering a more natural knee movement compared to posterior-stabilized knee replacements, which substitute these ligaments with a mechanical component.1281112
What is the purpose of this trial?
Total knee arthroplasty (TKA) with the sacrifice of the anterior cruciate ligament is the standard treatment for severe knee osteoarthritis. A number of studies on the kinematics of the prosthetic knee tend to show that implants that preserve the cruciate ligaments best reproduce the kinematics of the healthy knee. The goal is to compare the clinical and radiological results in patients undergoing total knee replacement surgery according to the type of prosthesis used. It is anticipated that the bicruciate-retaining prosthesis will result in better function of the operated knee than the posterior-stabilized prosthesis.Method:* Randomized controlled trial* Monocentric* Randomization will be done using sealed envelopes
Research Team
Frédéric Lavoie, MD, M.Sc
Principal Investigator
CHUM
Eligibility Criteria
This trial is for people under 70 with severe knee osteoarthritis needing a total knee replacement, who have failed conservative treatments. They must be able to fully extend the knee within 10 degrees and bend it past 90 degrees, have intact cruciate ligaments, less than 10 degrees of knee malalignment, and be capable of undergoing an EOS exam.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Pre-surgery Assessment
Demographic data, medical history, clinical assessment, and 4 questionnaires (IKS, KOOS, Marx, and SF-12) are completed. Standard x-ray, EOS imaging, TELOS radiological laximetry, and 3D kinematics evaluation are performed.
Surgery and Initial Recovery
Patients undergo total knee arthroplasty surgery with either BCR or PS prosthesis. Initial recovery and monitoring post-surgery.
Follow-up
Participants are monitored for safety and effectiveness after treatment. Follow-up assessments include questionnaires and radiological examinations at 6 weeks, 6 months, 1 year, 2 years, 5 years, and 10 years post-surgery.
Treatment Details
Interventions
- Bicruciate-retaining Total Knee Arthroplasty
- Posterior-stabilized Total Knee Arthroplasty
Find a Clinic Near You
Who Is Running the Clinical Trial?
Centre hospitalier de l'Université de Montréal (CHUM)
Lead Sponsor