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Ketone Supplement for Cognitive Health

N/A

Recruiting

Led By Jeremy Walsh, PhD

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

between the ages of 55 and 70

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 90 minutes

Awards & highlights

Study Summary

This trial looks at whether a single dose of ketone monoester can improve memory issues & help protect against dementia in adults.

Who is the study for?

This trial is for adults aged 55 to 70 who feel like their memory isn't as good as it used to be but are still cognitively normal, scoring ≥26 on a test called the Montreal Cognitive Assessment.Check my eligibility

What is being tested?

The study is testing if a single dose of ketone monoester, which could help brain function, has positive effects on how different parts of the brain communicate and blood flow in the brain compared to a placebo.See study design

What are the potential side effects?

Potential side effects from ketone supplements can include stomach discomfort, nausea, diarrhea, bad breath and high cholesterol levels. However, specific side effects will depend on individual reactions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 55 and 70 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 90 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~90 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Brain network connectivity

Cerebral blood flow

Secondary outcome measures

Attention and working memory

Executive function

Working memory

Other outcome measures

Mean arterial pressure

Plasma beta-hydroxybutyrate

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: β-OHBExperimental Treatment1 Intervention

Single dose of a ketone monoester ([R]-3-hydroxybutyl [R]-3-hydroxybutyrate; 0.6 g β-OHB/kg body weight)

Group II: PlaceboPlacebo Group1 Intervention

Single dose of a taste-matched calorie-free placebo

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor

884 Previous Clinical Trials

2,598,286 Total Patients Enrolled

1 Trials studying Cognition

20 Patients Enrolled for Cognition

Alzheimer's Society of Brant, Haldimand Norfolk, Hamilton HaltonUNKNOWN

Jeremy Walsh, PhDPrincipal InvestigatorMcMaster University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are currently engaged in the trial?

"Affirmative. Research posted on clinicaltrials.gov confirms that recruitment for this medical trial is ongoing, with the study being originally published in October 25th 2023 and recently updated in November 30th 2023. The aim of the project is to acquire thirty participants at a single location."

Answered by AI

Is this research undertaking currently enrolling participants?

"That is correct. The data on clinicaltrials.gov confirms that the research has been actively recruiting since October 25th of 2023, with a recent update occurring November 30th of the same year. This trial requires approximately 30 participants from one medical centre to participate in it."

Answered by AI

Is the enrollment of participants aged over 30 being considered for this clinical trial?

"This clinical trial has specified that any applicants must be between the ages of 55 and 75 in order to qualify. In addition, there are 5 trials specifically for individuals aged under 18 years old, as well as 23 separate studies available for those over 65."

Answered by AI

Do I meet the criteria to partake in this research?

"This clinical trial seeks 30 members aged between 55 and 75 years old with cognitive complaints. The prerequisite criteria include being of the specified age range, subjective memory concerns as gauged by a Prospective-Retrospective Memory Questionnaire, and achieving a score ≥26 on the Montreal Cognitive Assessment to indicate cognitive normalcy."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity

Jeremy Walsh 2023. "Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05992571.