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Ketone lower dose for Ketosis

N/A
Waitlist Available
Led By Martin J Gibala, PhD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Engaged in endurance-type exercise >3h/wk
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measurement made immediately prior to exercise
Awards & highlights

Study Summary

This trial will study how ketone supplements affect exercise efficiency by having participants take the supplement prior to exercise and testing their metabolic responses.

Eligible Conditions
  • Ketosis
  • Exercise

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You participate in more than three hours of endurance exercise per week.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measurement made at the end of each of three, 5-minute consecutive stages of an incremental cycle exercise test at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity
This trial's timeline: 3 weeks for screening, Varies for treatment, and measurement made at the end of each of three, 5-minute consecutive stages of an incremental cycle exercise test at relative workloads corresponding to 75%, 100%, and 125% of individual ventilatory threshold intensity for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Exercise efficiency
Secondary outcome measures
Heart rate
Ketone body content in venous blood
Rating of perceived exertion

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Ketone lower doseExperimental Treatment1 Intervention
An acute bout of exercise performed after the ingestion of a commercial supplement intended to provide ~0.3 g of ketone monoester per kg body mass of the participant.
Group II: Ketone higher doseExperimental Treatment1 Intervention
An acute bout of exercise performed after the ingestion of a commercial supplement intended to provide ~0.6 g of ketone monoester per kg body mass of the participant.
Group III: ControlPlacebo Group1 Intervention
An acute bout of exercise performed after the ingestion of a taste-matched placebo supplement.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketone monoester
2022
Completed Phase 2
~160

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
877 Previous Clinical Trials
2,596,026 Total Patients Enrolled
1 Trials studying Ketosis
25 Patients Enrolled for Ketosis
Martin J Gibala, PhDPrincipal InvestigatorMcMaster University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are elderly participants being engaged in the research endeavor?

"The eligibility criteria for this medical experiment requires participants to be aged between 18 and 60."

Answered by AI

Who qualifies to join this research program?

"To be approved for this medical trial, patients must have ketosis and are restricted to ages 18-60. This research effort is accepting approximately 30 individuals."

Answered by AI

Does this research endeavor have any new participants joining at the moment?

"Per the information made available on clinicaltrials.gov, this investigation is actively accepting participants. It was first posted at the end of December 2022 and has been most recently edited in April 2023."

Answered by AI

How many subjects are participating in this investigation?

"Affirmative. Clinicaltrials.gov reveals that recruitment is currently underway for this medical trial, which began on December 27th 2022 and was recently updated on April 4th 2023. A total of 30 patients are needed at a single site."

Answered by AI
~15 spots leftby Mar 2025