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Postoperative Monitoring for Liver Cancer Recovery

N/A

Recruiting

Led By Cherif Boutros, MD

Research Sponsored by University of Maryland, Baltimore

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients plan to have partial liver resection for primary liver pathology or metastatic disease.

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up three months after ph and liver function tests

Awards & highlights

Study Summary

This trial will monitor carbon monoxide production in patients post-liver resection, in order to establish a relationship to surgical recovery.

Who is the study for?

This trial is for adults who understand and agree to participate by signing a consent form, and are scheduled for partial liver resection due to primary liver disease or metastatic cancer. It excludes those under 18, unable to consent, or without pathology-proven liver malignancy.Check my eligibility

What is being tested?

The study tests if measuring carbon monoxide (CO) levels in blood and exhaled air after liver surgery can predict recovery. CO levels will be checked using routine arterial blood gas tests and a smokerlyzer device post-surgery.See study design

What are the potential side effects?

There may not be direct side effects from the interventions as they involve standard postoperative care testing procedures. However, risks associated with drawing blood for ABG testing include bruising or infection at the puncture site.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am planning to undergo surgery to remove part of my liver due to cancer.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ three months after ph and liver function tests

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~three months after ph and liver function tests

This trial's timeline: 3 weeks for screening, Varies for treatment, and three months after ph and liver function tests for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Measure HO-1 induction by measuring endogenous CO production in relationship to the extent of hepatic resection

Measure the extent of HO-1 induction by measuring endogenous CO production in relationship to the extent of hepatic resection

Secondary outcome measures

Measure the relationship between HO-1 induction and the quality of post-hepatectomy liver regeneration

Trial Design

1Treatment groups

Experimental Treatment

Group I: Intervention ArmExperimental Treatment3 Interventions

CO and ABG Testing Arm

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Maryland, BaltimoreLead Sponsor

688 Previous Clinical Trials

374,626 Total Patients Enrolled

Cherif Boutros, MDPrincipal InvestigatorUniversity of Maryland, Baltimore

1 Previous Clinical Trials

4 Total Patients Enrolled

Media Library

Intervention Arm Clinical Trial Eligibility Overview. Trial Name: NCT04195438 — N/A

Liver Cancer Research Study Groups: Intervention Arm

Liver Cancer Clinical Trial 2023: Intervention Arm Highlights & Side Effects. Trial Name: NCT04195438 — N/A

Intervention Arm 2023 Treatment Timeline for Medical Study. Trial Name: NCT04195438 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals can partake in this research initiative?

"Affirmative. Information available on clinicaltrials.gov indicates that this research trial is actively recruiting volunteers, having been first posted in May 2014 and updated most recently on the 13th of May 2022. The study seeks to enroll 30 people at a single centre."

Answered by AI

Are individuals eligible to join this clinical research at the present time?

"According to clinicaltrials.gov, the research team is currently recruiting participants for this study which was initially published on May 7th 2014 and last edited on May 13th 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy

2014. "Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04195438.