Reviewed by Michael Gill, B. Sc.
25 Fatty Liver Clinical Trials Near Me
Top Hospitals for Fatty Liver Clinical Trials
Image of South Texas Research Institute in Texas.
South Texas Research Institute
Edinburg
11Active Trials
13All Time Trials for Fatty Liver
2019First Fatty Liver Trial
Image of Pinnacle Clinical Research in Texas.
Pinnacle Clinical Research
San Antonio
8Active Trials
14All Time Trials for Fatty Liver
2016First Fatty Liver Trial
Top Cities for Fatty Liver Clinical Trials
Image of San Antonio in Texas.
San Antonio
76Active Trials
Pinnacle Clinical ResearchTop Active Site
Fatty Liver Clinical Trials by Phase of Trial
Phase < 1 Fatty Liver Clinical Trials
2Active Fatty Liver Clinical Trials
2Number of Unique Treatments
1Number of Active Locations
Hyperpolarized [13C] Pyruvate InjectionMAD Cohorts 1 to 4: Participants receiving ECC4703
Fatty Liver Clinical Trials by Age Group
< 18 Fatty Liver Clinical Trials
3Active Fatty Liver Clinical Trials
Empagliflozin 10 MGLFSDModerately carbohydrate-restricted diet
Top Treatments for Fatty Liver Clinical Trials
Treatment Name
Active Fatty Liver Clinical Trials
All Time Trials for Fatty Liver
First Recorded Fatty Liver Trial
Semaglutide
4
7
2016
Pioglitazone
2
14
2002
Resmetirom
2
2
2019
Fasting
2
2
2009
EFX
2
3
2019
Recently Completed Studies with FDA Approved Treatments for Fatty Liver
Treatment
Year
Sponsor
BIO89-100
2021
89bio, Inc.
Efinopegdutide 20 mg/mL
2021
Merck Sharp & Dohme Corp.
TERN-201
2021
Terns, Inc.
ORMD-0801 (Insulin) capsule 8 mg BD
2020
Oramed, Ltd.
PF-06865571
2020
Pfizer

What Are Fatty Liver Clinical Trials?

The liver is a crucial organ responsible for supporting multiple functions of the body. It aids digestion, stores iron, makes protein, provides energy by breaking down nutrients, and removes toxins. However, you may develop a fatty liver because of a diet rich in fats, alcohol abuse, diabetes, and obesity. Fatty liver is a health condition triggered when extra fat builds up in your liver. In this condition, fat weighs five to ten percent more than the liver.

Fatty liver is a serious health issue because it can gradually damage the liver. Therefore, fatty liver clinical trials are conducted to learn ways to prevent, detect and treat fatty liver. Recent studies focus on understanding different types of fatty liver diseases- alcohol-induced and non-alcohol fatty liver.

Why Is Fatty Liver Being Studied Through Clinical Trials?

According to UCLA Health, the prevalence of fatty liver is between 10 and 46 percent. Though the disease doesn’t cause serious issues, the condition can worsen in 30 percent of people with NFLD (Non-alcoholic fatty liver disease) over time. Fatty liver disease progresses through 3 crucial stages:

  • Steatohepatitis- The liver becomes inflamed.
  • Fibrosis- scar tissue is formed
  • Cirrhosis- healthy tissue is replaced by scarred tissue.

Individuals with fatty liver may not have any symptoms until they reach the third stage- cirrhosis. However, symptoms may include abdominal pain, weight loss, jaundice, edema, weakness, and nausea.

Approximately 100 million people in the US are affected by the non-alcoholic fatty liver condition. It costs the healthcare industry in the US around $32 billion yearly. The economic burden of the NFLD has increased the need for clinical trials to find treatments to save lives and money. Moreover, they must find the best therapeutic and nutritional ways to alleviate the condition before people reach the last stage of liver disease.

What Are the Types of Treatments Available for Fatty Liver?

Currently, no medication or surgical treatment is available for fatty liver. However, people with NFLD can take specific steps and measures to reverse and prevent some damage. For example, a clinical trial showed that weight loss could help improve non-alcoholic fatty liver. Physical activities like exercise and healthy dietary habits can reduce weight. This can significantly help lower fat content in the liver.

Other ways to alleviate NFLD are:

  • Avoiding alcohol
  • Controlling diabetes
  • Lowering triglyceride levels

What Are Some Recent Breakthrough Clinical Trials for Fatty Liver?

In recent years, numerous studies have been conducted to alleviate fatty liver health conditions. Some of the most recent studies include the following:

2021: Empagliflozin Improves Liver Steatosis and Fibrosis- The placebo-controlled trial focused on evaluating the efficacy of Empagliflozin ( a drug used for diabetes) to alleviate NAFLD. It included 106 patients with both type 2 diabetes and NAFLD for 24 weeks. They received 10 mg of Empagliflozin, 30mg of pioglitazone, or a placebo. Treatment with empagliflozin for 24 weeks showed improvement in patients in the fibrosis and steatosis stages. Moreover, it also decreased abdominal fat in patients and overall body weight.

2019: Effect of Orlistat on liver fat content- The study focused on using Orlistat to control and manage weight in people with NFLD. After 24 weeks of research conducted on parallel groups, it was concluded that Orlistat effectively promotes steatosis improvement. This research is expected to be a breakthrough in providing a treatment option for NAFLD.

Who Are Some of the Key Opinion Leaders/Researchers/Institutions Conducting Fatty Liver Clinical Trial Research?

NAFLD Research Center of UC San Diego is strongly committed to conducting translational research in non-alcoholic fatty liver disease to pursue effective treatments.

Pinnacle Clinical Research is focused on the early detection and treatment of fatty liver in patients. The organization strives to educate the community through ongoing clinical trials and research studies.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 3rd, 2021

Last Reviewed: November 6th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.