Dietary Oils for Fatty Liver Disease
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot use Vitamin E supplements, Actos, or certain diabetes medications less than a month before enrolling. Also, if your medications conflict with the study foods, you may not be eligible.
What data supports the effectiveness of the treatment Palm Oil Foods, Soybean Oil Foods for fatty liver disease?
Research suggests that adding soybean oil to a diet can help reduce early signs of liver damage and glucose intolerance in mice, which are related to fatty liver disease. Additionally, a blend of lard and soybean oil improved liver function markers in humans, indicating potential benefits for liver health.12345
Is it safe to consume palm oil and soybean oil for liver health?
Palm oil and soybean oil have been studied for their effects on liver health. Palm oil, especially when oxidized, may pose risks to liver health, while moderate consumption of red or refined palm oil might be safer. Soybean oil, when mixed with lard, showed benefits for liver function markers in healthy people.25678
How does the treatment with palm oil and soybean oil foods differ from other treatments for fatty liver disease?
This treatment is unique because it involves dietary modification using palm oil and soybean oil foods, which may influence liver health differently compared to other treatments. Palm oil is known to affect liver fat and metabolism, while soybean oil has been shown to improve liver function markers in some studies, potentially offering a novel dietary approach to managing fatty liver disease.125910
What is the purpose of this trial?
The research study is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in hepatic lipid accumulation, visceral adipose tissue and postprandial lipid, markers of inflammation and energy metabolism in participants who consume 3 study foods per day for 16 week, while maintaining their body weight.
Eligibility Criteria
The WELL Study is for adults with Nonalcoholic Fatty Liver Disease (NAFLD) or similar conditions, who are nonsmokers with a BMI of 25-55 kg/m2. It's not for those with heart issues, pregnant or breastfeeding women, people unable to undergo venipuncture, those on certain diets or medications that conflict with the study foods, and individuals with specific gastrointestinal diseases, kidney failure, some liver and pulmonary diseases.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume 3 study foods per day for 16 weeks, with either soybean oil or palm oil, while maintaining their body weight
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Palm Oil Foods
- Soybean Oil Foods
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor