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Radiation Therapy
MRI-Guided Radiotherapy for Prostate Cancer
N/A
Waitlist Available
Led By Dian Wang, MD, PhD
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
NCCN Low to High Risk localized prostate cancer
Zubrod Performance Status 0-1 within 60 days prior to registration
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18 months
Awards & highlights
Study Summary
This trial is testing two different radiotherapy regimens for prostate cancer, one for patients without identifiable lesions and one for those with lesions, using MRI to guide treatment.
Who is the study for?
This trial is for men with prostate cancer diagnosed within the last year, who are in good physical condition (able to carry out daily activities without significant limitations). They must not have cancer spread to lymph nodes or distant sites, no history of pelvic radiation, severe illnesses like heart disease or uncontrolled infections, and they can't have had prior chemotherapy or other invasive cancers except skin cancer.Check my eligibility
What is being tested?
The study tests two radiotherapy approaches using MRI guidance. Men without visible lesions get a short course of SBRT to the whole prostate. Those with lesions receive longer IMRT treatment followed by an intense SBRT boost specifically targeting the identified lesions.See study design
What are the potential side effects?
Potential side effects include urinary issues such as increased frequency and discomfort, bowel changes like diarrhea, fatigue during treatment weeks, and possible sexual dysfunction due to radiation affecting nearby tissues.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My prostate cancer is classified from low to high risk but not spread.
Select...
I have been mostly active and able to carry on all pre-disease activities without restriction in the last 60 days.
Select...
My prostate cancer was confirmed by a biopsy within the last year.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 18 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Number of Participants With Late Radiation Induced Genitourinary and Gastrointestinal Toxicity
Secondary outcome measures
Biochemical Recurrence
Disease Free-Survival
Number of Participants With Acute Radiation Induced Genitourinary Adverse Event
Trial Design
2Treatment groups
Experimental Treatment
Group I: Positive mpMRI Prostate ScanExperimental Treatment1 Intervention
IMRT to the prostate + seminal vesicles followed by SBRT boost to the whole prostate with SIB to MRI defined intraprostatic lesions
Group II: Negative mpMRI Prostate ScanExperimental Treatment1 Intervention
SBRT to the whole prostate
Find a Location
Who is running the clinical trial?
Rush University Medical CenterLead Sponsor
422 Previous Clinical Trials
163,477 Total Patients Enrolled
Dian Wang, MD, PhDPrincipal InvestigatorRush University Medical Center
1 Previous Clinical Trials
98 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am currently on IV antibiotics for a serious bacterial or fungal infection.I have had chemotherapy before.I do not have severe heart, lung, liver diseases, or AIDS.You are unable to have an MRI scan.You cannot receive small markers inside your body to help guide treatment.I have or had cancer other than non-melanoma skin cancer.My prostate cancer is classified from low to high risk but not spread.I have been mostly active and able to carry on all pre-disease activities without restriction in the last 60 days.My cancer has spread to nearby lymph nodes.My cancer has spread to distant parts of my body.I have had radiation therapy to my pelvic area before.My prostate cancer was confirmed by a biopsy within the last year.
Research Study Groups:
This trial has the following groups:- Group 1: Negative mpMRI Prostate Scan
- Group 2: Positive mpMRI Prostate Scan
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are recruitment and enrollment for this research still active?
"This clinical trial is not presently accepting applicants, as indicated on the related entry hosted by clinicaltrials.gov. The record was initially published on May 23rd 2016 and most recently amended January 24th 2021. Despite this study no longer recruiting participants, there are 1321 other trials actively enrolling patients at present."
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