Stellate Ganglion Block for Chronic Pain

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Rush University Medical Center, Chicago, IL
Chronic Pain+3 More
Stellate Ganglion Block Treatment - Procedure
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

Cognitive Processing Therapy (CPT) is an effective first-line, evidence-based treatment for posttraumatic stress disorder (PTSD). Despite its well-demonstrated effectiveness, research has shown that approximately two-thirds of individuals continue to meet the diagnostic criteria for PTSD even after successful treatment completion. Stellate Ganglion Block (SGB) treatment, involving a local anesthesia injection to the stellate ganglion (around the lower base of the neck), has been shown to block its pain signal transmissions. Prior case studies and reviews have provided evidence for reducing PTSD symptoms with SGB treatment. However, studies to date have only examined SGB as a standalone intervention. The utility of combining CPT with concurrent SGB treatment remains unknown, although it is plausible that the combination of the two treatments can improve the effectiveness of CPT alone. The present study aims to test this hypothesis by comparing either a combined 1-week massed CPT + SGB treatment and 1-week massed CPT + placebo treatment (saline injection) using a randomized controlled trial design.

Eligible Conditions

  • Chronic Pain
  • Post Traumatic Stress Disorder (PTSD)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: Through study completion, on average of 3 months

Month 3
Clinician Administered PTSD Scale for DSM-5
PTSD Checklist for DSM-5 Criteria

Trial Safety

Trial Design

2 Treatment Groups

Stellate Ganglion Block
1 of 2
Placebo
1 of 2
Active Control
Non-Treatment Group

150 Total Participants · 2 Treatment Groups

Primary Treatment: Stellate Ganglion Block · Has Placebo Group · N/A

Stellate Ganglion Block
Procedure
ActiveComparator Group · 1 Intervention: Stellate Ganglion Block Treatment · Intervention Types: Procedure
Placebo
Procedure
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Procedure

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: through study completion, on average of 3 months

Trial Background

Philip Held, Research Director
Principal Investigator
Rush University Medical Center
Closest Location: Rush University Medical Center · Chicago, IL
Photo of rush university medical center  1Photo of rush university medical center  2Photo of rush university medical center  3
2011First Recorded Clinical Trial
9 TrialsResearching Chronic Pain
790 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 9 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have safe transportation means other than driving yourself to Rush University Medical Center for two separate procedures (e.g., Uber, family or friend to drive them to study visits, etc.
You are willing and able to participate in daily Cognitive Processing Therapy over the course of one week.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.