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Stellate Ganglion Block + Cognitive Processing Therapy for PTSD (SGB Trial)

N/A
Recruiting
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have a PTSD diagnosis verified via the Clinician Administered PTSD Scale for DSM-5
Have not previously received stellate ganglion blocks
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, on average of 3 months
Awards & highlights

SGB Trial Summary

This trial is examining whether combining Cognitive Processing Therapy with a Stellate Ganglion Block, which involves a local anesthesia injection to the neck, is more effective in reducing PTSD symptoms than CPT alone.

Who is the study for?
This trial is for adults over 18 in Illinois who have PTSD from a past traumatic event and can attend daily therapy for one week. They must speak English, have safe transport to the medical center, and not be on blood thinners or have certain health conditions like unmanaged psychosis, recent heart attack, or severe emphysema.Check my eligibility
What is being tested?
The study tests if Cognitive Processing Therapy (CPT) for PTSD works better when combined with Stellate Ganglion Block (SGB), an injection that blocks pain signals. Participants will either receive CPT + SGB or CPT + placebo in a randomized controlled trial over one week.See study design
What are the potential side effects?
Possible side effects of the Stellate Ganglion Block treatment include soreness at the injection site, light-headedness, temporary voice changes due to local anesthesia effects on vocal cords, and rare complications related to needle placement.

SGB Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with PTSD by a professional using the CAPS-5.
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I have never had a stellate ganglion block procedure.
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I am willing and able to attend daily therapy sessions for one week.
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I am 18 years old or older.

SGB Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, on average of 3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, on average of 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Clinician Administered PTSD Scale for DSM-5
PTSD Checklist for DSM-5 Criteria

SGB Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Stellate Ganglion BlockActive Control1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
422 Previous Clinical Trials
163,351 Total Patients Enrolled

Media Library

Stellate Ganglion Block Clinical Trial Eligibility Overview. Trial Name: NCT05534126 — N/A
Post-Traumatic Stress Disorder Research Study Groups: Stellate Ganglion Block, Placebo
Post-Traumatic Stress Disorder Clinical Trial 2023: Stellate Ganglion Block Highlights & Side Effects. Trial Name: NCT05534126 — N/A
Stellate Ganglion Block 2023 Treatment Timeline for Medical Study. Trial Name: NCT05534126 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies in this research protocol for new participants?

"Evidently, this medical study is still recruiting patients as the trial listing on clinicaltrials.gov has been recently updated in November 18th 2022 after its initial posting date of November 1st 2022."

Answered by AI

How many participants are now involved in this investigation?

"Affirmative. Per the data available on clinicaltrials.gov, this scientific investigation is actively recruiting candidates; it was released on November 1st 2022 and its most recent update came out on November 18th 2022. At present, 150 participants are being sought from a single medical centre."

Answered by AI

Who else is applying?

What site did they apply to?
Rush University Medical Center
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I have significant episodes of somatic symptoms that are intense sympathetic responses that are uninhibited. My flight or fight response is triggered without a conscious trigger and lasts for 4-6 hours with intense physiological symptoms and takes 1-2 days to recover. It is a sympathetic dysautonomia. Medication has not been helpful.
PatientReceived no prior treatments

How responsive is this trial?

Typically responds via
Phone Call
Most responsive sites:
  1. Rush University Medical Center: < 48 hours
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial
Philip Held 2022. "Enhancing Cognitive Processing Therapy for Posttraumatic Stress Disorder Via Stellate Ganglion Block Treatment: A Pilot Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05534126.
All > Ptsd Chicago
~93 spots leftby Oct 2026
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