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Gas Delivery

Carbon Dioxide Breathing for Orthostatic Hypotension

N/A

Recruiting

Led By Satish R Raj, MD

Research Sponsored by University of Calgary

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age ≥18 years

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up the δ vanderbilt orthostatic symptom score (symptoms at the 5th minute of stand - symptoms at the 5th minute of sit) will be compared between room air and +10mmhgco2/50mmhg o2

Awards & highlights

Study Summary

This trial is testing if breathing in carbon dioxide can help people with Neurogenic Orthostatic Hypotension, a condition where the "fight-or-flight" part of the nervous system fails.

Who is the study for?

This trial is for adults over 18 who can consent, travel to the University of Calgary, and are non-smokers. It's not for those with dementia, substance abuse issues, severe organ diseases, pregnant or breastfeeding women, people on certain medications affecting autonomic function or unable to wear a mask.Check my eligibility

What is being tested?

The study tests if breathing in higher levels of carbon dioxide (Sequential Gas Delivery) can help manage low blood pressure when standing in patients with Neurogenic Orthostatic Hypotension by increasing blood pressure and brain blood flow.See study design

What are the potential side effects?

Potential side effects may include discomfort from wearing a mask to deliver the gas and possible short-term changes in respiratory patterns due to increased carbon dioxide inhalation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ the δ vanderbilt orthostatic symptom score (symptoms at the 5th minute of stand - symptoms at the 5th minute of sit) will be compared between room air and +10mmhgco2/50mmhg o2

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~the δ vanderbilt orthostatic symptom score (symptoms at the 5th minute of stand - symptoms at the 5th minute of sit) will be compared between room air and +10mmhgco2/50mmhg o2

This trial's timeline: 3 weeks for screening, Varies for treatment, and the δ vanderbilt orthostatic symptom score (symptoms at the 5th minute of stand - symptoms at the 5th minute of sit) will be compared between room air and +10mmhgco2/50mmhg o2 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Secondary outcome measures

Bronchial Provocation Tests

Δ Cerebral Blood Flow Velocity (CBFv)

Δ Vanderbilt Orthostatic Symptom Score [Range: 0 (absent) to 10 (worst)]

Trial Design

5Treatment groups

Experimental Treatment

Active Control

Group I: +5mmHg CO2Experimental Treatment1 Intervention

All participants will complete an active stand breathing +5mmHg of CO2 relative to baseline

Group II: +10mmHg CO2 + 50mmHg O2Experimental Treatment1 Intervention

All participants will complete an active stand breathing +10mmHg of CO2 relative to baseline and 50mmHg of O2

Group III: +10mmHgExperimental Treatment1 Intervention

All participants will complete an active stand breathing +10mmHg of CO2 relative to baseline

Group IV: +0mmHg CO2 Clamped at baselineExperimental Treatment1 Intervention

All participants will complete an active stand with their CO2 held constant at baseline

Group V: Room AirActive Control1 Intervention

All participants will complete an active stand breathing room air with CO2 free to fluctuate

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor

792 Previous Clinical Trials

869,074 Total Patients Enrolled

Satish R Raj, MDPrincipal InvestigatorUniversity of Calgary

2 Previous Clinical Trials

48 Total Patients Enrolled

Media Library

Sequential Gas Delivery (Gas Delivery) Clinical Trial Eligibility Overview. Trial Name: NCT05295810 — N/A

Orthostatic Hypotension Research Study Groups: Room Air, +0mmHg CO2 Clamped at baseline, +5mmHg CO2, +10mmHg, +10mmHg CO2 + 50mmHg O2

Orthostatic Hypotension Clinical Trial 2023: Sequential Gas Delivery Highlights & Side Effects. Trial Name: NCT05295810 — N/A

Sequential Gas Delivery (Gas Delivery) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05295810 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I enter this trial as a participant?

"80 persons, both genders, aged between 18 and 100 years with orthostatic hypotension are requested to enroll in this trial. In addition to the age requirement they must be non-smokers; capable of providing informed consent; able to travel to Libin Cardiovascular Institute's Autonomic Testing Lab at the University of Calgary in Alberta; and willing participants."

Answered by AI