38 Participants Needed

RP-6306 for Advanced Cancer

(MINOTAUR Trial)

Recruiting at 22 trial locations
PM
JT
NH
Overseen ByNathan Hawkey, MD, MBA
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests the safety and effectiveness of combining a new drug, RP-6306, with standard chemotherapy (FOLFIRI) in patients with advanced cancers. The goal is to find the best dose and schedule while checking for side effects and early signs of effectiveness.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot have had chemotherapy or certain cancer drugs within 21 days before starting the study treatment.

Who Is on the Research Team?

NH

Nathan Hawkey

Principal Investigator

Repare RX

Are You a Good Fit for This Trial?

Adults over 18 with advanced solid tumors like colorectal, gastrointestinal, or esophageal cancer that's getting worse despite treatment. They must be able to perform daily activities with ease or only have minor limitations (ECOG score of 0-1), and women who can have children need a negative pregnancy test.

Inclusion Criteria

My advanced cancer has not responded to standard treatments.
I am fully active or can carry out light work.
I can provide tumor tissue or am willing to undergo a biopsy if it's safe.
See 4 more

Exclusion Criteria

Life-threatening illness, medical condition, active uncontrolled infection, or organ system dysfunction or other reasons which, in the investigator's opinion, could compromise the participating patient's safety
I cannot swallow or keep down pills.
I haven't had chemotherapy or targeted cancer drugs within the last 3 weeks.
See 9 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive RP-6306 in combination with FOLFIRI to determine the maximum tolerated dose and assess safety and tolerability

Up to 3 months
Multiple visits for dose escalation and monitoring

Follow-up

Participants are monitored for safety and effectiveness after treatment

3 months

What Are the Treatments Tested in This Trial?

Interventions

  • RP-6306
Trial Overview The trial is testing RP-6306 combined with FOLFIRI chemotherapy in patients with certain advanced solid tumors. It aims to find the safest dose, see how well it works against the cancer, and figure out the best dosage schedule.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Phase 1: RP-6306 in combination with FOLFIRI Dose EscalationExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Repare Therapeutics

Lead Sponsor

Trials
10
Recruited
1,300+
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
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