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Psychological Interventions for Pain Perception

N/A
Recruiting
Led By Lauren Y Atlas, Ph.D.
Research Sponsored by National Center for Complementary and Integrative Health (NCCIH)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Between 18 and 50 years old
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during the study visit in response to painful and non-painful stimuli.
Awards & highlights

Study Summary

This trial is testing how different psychological factors influence pain and the response to pain.

Who is the study for?
This trial is for healthy individuals between the ages of 18 and 50 who speak English fluently and can consent to participate. It's not suitable for those with conditions affecting touch sensation, chronic pain history, skin issues in test areas, major medical conditions that affect heat sensitivity or pain thresholds, pregnancy, NCCIH/NIMH employees, or regular use of certain prescription medications.Check my eligibility
What is being tested?
The study aims to understand how psychological factors like expectations influence pain perception and decision-making. Participants may undergo MRI scans while experiencing controlled thermal pain or electric shocks, perform tasks, take taste tests, and complete questionnaires during one to two clinic visits over three years.See study design
What are the potential side effects?
There are no direct side effects from the interventions as this study involves non-invasive procedures such as MRI scans and monitored exposure to controlled painful stimuli (heat or electric shocks). However discomfort from these stimuli and loud noises from MRIs despite earplugs could be expected.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 50 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~trait measures are collected during initial screening visit ; state measures are collected on every visit
This trial's timeline: 3 weeks for screening, Varies for treatment, and trait measures are collected during initial screening visit ; state measures are collected on every visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
BOLD response in brain regions of interest measured using fMRI
Pain perception (pain ratings)
Physiological responses (heart rate, skin conductance, respiration, pupil dilation, eye gaze position)
Secondary outcome measures
Questionnaire measures (e.g. State-trait anxiety index, Fear of Pain questionnaire, Intolerance of Uncertainty questionnaire, McGill Pain Questionnaire)

Trial Design

8Treatment groups
Experimental Treatment
Active Control
Group I: Substudy 5: healthy volunteersExperimental Treatment2 Interventions
Participants experience both placebo and cue-based expectations within subjects
Group II: Substudy 4: healthy volunteersExperimental Treatment1 Intervention
Participants are instructed to attend toward or away from the stimulus
Group III: Substudy 2: sugar groupExperimental Treatment1 Intervention
Participants learn about sugar outcomes through conditioning
Group IV: Substudy 2: salt groupExperimental Treatment1 Intervention
Participants learn about salt outcomes through conditioning
Group V: Substudy 2: heat groupExperimental Treatment1 Intervention
Participants learn about heat outcomes through conditioning
Group VI: Substudy 1: Uninstructed subjectsExperimental Treatment1 Intervention
Participants learn through experience
Group VII: Substudy 1: Instructed subjectsExperimental Treatment1 Intervention
Participants are instructed about outcomes
Group VIII: Substudy 3: healthy volunteersActive Control1 Intervention
All participants experience all outcomes, within subjects designs
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Attention
2015
N/A
~150
Instructions
2021
N/A
~110

Find a Location

Who is running the clinical trial?

National Center for Complementary and Integrative Health (NCCIH)Lead Sponsor
832 Previous Clinical Trials
668,433 Total Patients Enrolled
33 Trials studying Pain
19,280 Patients Enrolled for Pain
Lauren Y Atlas, Ph.D.Principal InvestigatorNational Center for Complementary and Integrative Health (NCCIH)
2 Previous Clinical Trials
10,600 Total Patients Enrolled
2 Trials studying Pain
10,600 Patients Enrolled for Pain

Media Library

Substudy 1: Uninstructed subjects Clinical Trial Eligibility Overview. Trial Name: NCT02446262 — N/A
Pain Research Study Groups: Substudy 1: Uninstructed subjects, Substudy 2: heat group, Substudy 4: healthy volunteers, Substudy 2: sugar group, Substudy 3: healthy volunteers, Substudy 2: salt group, Substudy 5: healthy volunteers, Substudy 1: Instructed subjects
Pain Clinical Trial 2023: Substudy 1: Uninstructed subjects Highlights & Side Effects. Trial Name: NCT02446262 — N/A
Substudy 1: Uninstructed subjects 2023 Treatment Timeline for Medical Study. Trial Name: NCT02446262 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research open to seniors aged eighty-five or more?

"To be eligible for this clinical trial, the participant must have attained legal adulthood and be younger than 50 years old."

Answered by AI

Are individuals able to join this medical experiment at present?

"Clinicaltrials.gov confirms that this medical trial is still recruiting patients; the study was first made available on June 11th, 2015 and last modified on November 17th 2022."

Answered by AI

Is it feasible for me to participate in this clinical experiment?

"This trial has a cap of 500 participants and all must meet the following requirements: health, 18-50 years old age range, English literacy skills, and provide written consent to participate."

Answered by AI

What is the current study population for this clinical trial?

"Affirmative. According to clinicaltrials.gov, the medical trial which was created on June 11th 2015 is still in need of participants. 500 individuals are sought after across two sites for this study and it underwent its most recent update back in November 17th 2022."

Answered by AI

Who else is applying?

What site did they apply to?
National Institutes of Health Clinical Center, 9000 Rockville Pike
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Neural and Psychological Mechanisms of Pain Perception
2015. "Neural and Psychological Mechanisms of Pain Perception". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02446262.
All > Pain Management > Psychological
~5 spots leftby Jun 2024
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