Treatment for Arthroplasties, Replacement, Knee

Phase-Based Estimates
3
Effectiveness
3
Safety
Rhode Island Hospital, Providence, RI
+1 More
Eligibility
18+
All Sexes
Eligible conditions
Arthroplasties, Replacement, Knee

Study Summary

This study is evaluating whether a local anesthetic injection may help reduce pain after knee surgery.

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Eligible Conditions

  • Arthroplasties, Replacement, Knee
  • Total Knee Arthroplasty (TKA)

Treatment Effectiveness

Effectiveness Estimate

3 of 3
This is better than 93% of similar trials

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 2 secondary outcomes in patients with Arthroplasties, Replacement, Knee. Measurement will happen over the course of 24 hours.

24 hours
Postoperative opioid consumption
Quality of Recovery
Hour 24
Pain Scores

Trial Safety

Safety Estimate

3 of 3
This is better than 85% of similar trials

Trial Design

2 Treatment Groups

Ultrasound-guided adductor canal block with saline
Placebo group

This trial requires 120 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.

Ultrasound-guided adductor canal block with saline
Drug
Single shot Ultrasound-guided adductor canal block with 30 mL of normal saline (Sodium chloride)
Ultrasound-guided adductor canal block with local anesthetic
Drug
Single shot Ultrasound-guided adductor canal block with 0.5% ropivacaine 30 ml

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 2 hours (post anesthesia recovery unit), 6 hours, 12 hours, and 24 hours after surgery.
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 2 hours (post anesthesia recovery unit), 6 hours, 12 hours, and 24 hours after surgery. for reporting.

Closest Location

Rhode Island Hospital - Providence, RI

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
ASA PS 1-3 patients undergoing primary, unilateral total knee arthroplasty

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes arthroplasties, replacement, knee?

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This national survey demonstrates a need for standardization of coding for procedures and implants used to treat osteoarthritis of the knee, with codes that have the necessary detail to identify the procedure and implant but still are concise, so that operative risk is not negatively affected by too much text.

Unverified Answer

What is arthroplasties, replacement, knee?

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Knee replacements are an effective and long-term treatment for osteoarthritis of the knee. The patient's age, prior symptoms, activity level, the quality of life and a patient's perception of the prostheses all affect outcome. The overall satisfaction with the prostheses is higher than is typically reported in the literature, irrespective of patient expectations. Patients may require revision to correct problems with function and pain for many years to come. In a recent study, findings of revisions show the value of selecting the revision technique that best suits the patient. For all patients, the quality of life and function will change after the operation.

Unverified Answer

Can arthroplasties, replacement, knee be cured?

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The current literature does not support the idea that arthroscopic, arthroplasty, and resurfacing can be cured in either short term or long term. There are some exceptions to the cure theory.

Unverified Answer

How many people get arthroplasties, replacement, knee a year in the United States?

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The US prevalence of primary TKR in 2015 is 15.9 persons per 100,000. While the number has remained fairly stable between 2006 and 2015 (17.7 per 100,000), the rate has increased 20% from 2014 to 2015. The average pre‑hospital transfer time decreased from 1.6 days to 1.4 days between 2006 and 2015. Because these data suggest an unmet need for primary TKR, strategies to increase capacity should be developed.

Unverified Answer

What are common treatments for arthroplasties, replacement, knee?

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There are many methods used to treat TKR, and the choice depends primarily on the type of prosthesis and soft tissue quality available. There is a paucity of research supporting current treatments; thus, further research needs to be conducted as to which type of surgical technique yields the most functional product in conjunction with the most satisfying quality of life.

Unverified Answer

What are the signs of arthroplasties, replacement, knee?

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There were no signs associated with knee replacement in the 2 weeks that followed surgery. However, there was a small increase in pain on the knee which led to knee movements in the early post-operative period. Further studies are needed to confirm these findings with larger numbers of patients and a longer follow-up period.

Unverified Answer

Is treatment typically used in combination with any other treatments?

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The authors found no evidence of a significant effect of treatment using some other treatments; however, they did find a significant effect of treatment using some medications for depression and osteoarthrosis.

Unverified Answer

How serious can arthroplasties, replacement, knee be?

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We can safely say that arthroplasties and resurfacing procedures of the knee are procedures with a low rate of reintervention to replace the implant, so far no complications.

Unverified Answer

Does arthroplasties, replacement, knee run in families?

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This is a preliminary study, and no conclusions can be drawn yet. Nevertheless, it should help patients, families, and those willing to become a part of this field to make an informed decision regarding the best treatment options for their problem, and the impact of their disease on their future quality of life.

Unverified Answer

What does treatment usually treat?

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A treatment usually treats the symptoms of a disease such as pain or fatigue; the treatment itself is sometimes used only to prevent further symptoms from occurring or to address or modify a condition.

Unverified Answer

Have there been any new discoveries for treating arthroplasties, replacement, knee?

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Although several new drugs are in development for arthroplasties, replacement of the knee with either metal-on-metal or metal-on-polyethylene total-knee resurfacing has now become a standard of care which may affect the future clinical practice of arthroplasties.

Unverified Answer

Is treatment safe for people?

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The procedure was acceptable to patients and their family members. Early removal of the device was associated with increased risk of infection. There were two cases of implant failure which caused temporary infection and necessitated revision surgery. There was no effect on final result.

Unverified Answer
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