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Local Anesthetic

Continuous Nerve Block for Post-Knee Replacement Pain

N/A

Recruiting

Led By Naveed Siddiqui, MD, MSc

Research Sponsored by University of Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients older than 21 years of age

American Society of Anesthesiologists (ASA) physical status I-III

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 90

Awards & highlights

Study Summary

This trial aims to see if using a continuous nerve block during total knee arthroplasty can improve outcomes and pain management compared to single shot nerve blocks.

Who is the study for?

This trial is for patients over 21 years old who are having knee replacement surgery as outpatients and have a moderate risk of complications (ASA I-III). They should not be dependent on alcohol or drugs, understand the treatment process, and cannot be using strong painkillers regularly. People with allergies to study meds, blood clotting issues, low platelet counts, or problems where the catheter goes can't join.Check my eligibility

What is being tested?

The study tests if continuous adductor canal block (CACB), which involves infusing pain medication through a tube near nerves in the thigh, provides better pain control and recovery after outpatient knee surgery compared to a sham procedure without real medicine (ShACB).See study design

What are the potential side effects?

Potential side effects may include discomfort at the catheter site, infection risk from the tube placement, possible nerve damage around the thigh area where medication is infused, and typical reactions to local anesthetics like numbness or weakness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am older than 21 years.

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My overall health is good to moderately impaired.

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I am having knee replacement surgery on one knee as an outpatient.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 90

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 90

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 90 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Quality of Recovery 15 score (QoR-15)

Secondary outcome measures

Opioid usage

Pain scores

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Continuous adductor canal block (CACB)Experimental Treatment1 Intervention

Will receive an infusion of 0.2% ropivacaine 5mL/h through adductor canal catheter.

Group II: Sham continuous adductor canal block (ShACB).Placebo Group1 Intervention

Will receive an infusion of NaCl 0.9% 5mL/h through adductor canal catheter.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of TorontoLead Sponsor

690 Previous Clinical Trials

1,019,587 Total Patients Enrolled

MOUNT SINAI HOSPITALOTHER

40 Previous Clinical Trials

14,575 Total Patients Enrolled

1 Trials studying Acute Pain

400 Patients Enrolled for Acute Pain

Naveed Siddiqui, MD, MScPrincipal InvestigatorUniversity of Toronto

1 Previous Clinical Trials

223 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people are being enrolled in this experiment?

"Affirmative. According to information available on clinicaltrials.gov, the trial in question is actively recruiting participants since it was initially posted on October 1st, 2023 with a recent update performed October 12th of the same year. The current goal is to enrol 56 patients from one medical centre."

Answered by AI

Does this research endeavor still need volunteers?

"Affirmative. According to the clinicaltrials.gov data, this medical trial is actively looking for volunteers and was first posted on October 1st 2023 before being updated most recently on December 10th 2023. This study needs 56 patients from a single site in order to move forward."

Answered by AI

Recent research and studies

MedicineJournal

Is Continuous Catheter Adductor Canal Block Better Than Single-shot Canal Adductor Canal Block in Primary Total Knee Arthroplasty?

Sun, Changjiao, Xiaofei Zhang, Fei Song, Zhe Zhao, Ruiyong Du, Sha Wu, Qi Ma, and Xu Cai. 2020. “Is Continuous Catheter Adductor Canal Block Better Than Single-shot Canal Adductor Canal Block in Primary Total Knee Arthroplasty?”. Medicine. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/md.0000000000020320.

Anesthesia & AnalgesiaJournal

The Association Between Lower Extremity Continuous Peripheral Nerve Blocks and Patient Falls After Knee and Hip Arthroplasty

Ilfeld, Brian M., Kimberly B. Duke, and Michael C. Donohue. 2010. “The Association Between Lower Extremity Continuous Peripheral Nerve Blocks and Patient Falls After Knee and Hip Arthroplasty”. Anesthesia & Analgesia. Ovid Technologies (Wolters Kluwer Health). doi:10.1213/ane.0b013e3181fb9507.

MedicineJournal

Continuous Adductor Canal Block Provides Better Performance After Total Knee Arthroplasty Compared with the Single-shot Adductor Canal Block?

Yu, Rongguo, Haiyang Wang, Youguang Zhuo, Dongxin Liu, Chunling Wu, and Yiyuan Zhang. 2020. “Continuous Adductor Canal Block Provides Better Performance After Total Knee Arthroplasty Compared with the Single-shot Adductor Canal Block?”. Medicine. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/md.0000000000022762.

Journal of Clinical AnesthesiaJournal