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Procedure

Nerve Block Techniques for Postoperative Pain from Knee Surgery

N/A

Recruiting

Led By Maxim Roy, MD, FRCPC

Research Sponsored by Centre hospitalier de l'Université de Montréal (CHUM)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

18 years and over, requiring a primary total knee arthroplasty

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 hours, 12 hours, 18 hours and 24 hours after the surgery

Awards & highlights

Study Summary

This trial is exploring a nerve block technique that could improve pain relief & mobility after total knee replacement surgery.

Who is the study for?

This trial is for adults over 18 needing a primary total knee replacement, with an 'American Society of Anesthesiologists' classification of 1 to 3. It's not for those who can't consent or communicate with the team, don't understand instructions, are pregnant, weigh under 50 kg, have contraindications to nerve blocks or take daily pain meds equivalent to more than 60 mg of morphine.Check my eligibility

What is being tested?

The study tests if adding a para-sartorial compartments (PACS) block to the femoral triangle block (FTB) improves pain relief after knee replacement surgery. The PACS aims at blocking additional nerves that aren't covered by FTB alone and could enhance postoperative analgesia allowing earlier mobilization.See study design

What are the potential side effects?

Potential side effects may include discomfort at the injection site, risk of infection from the needle puncture, possible nerve damage leading to numbness or weakness in the leg and allergic reactions to local anesthetics used during the blocks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am over 18 and need a total knee replacement.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 hours after the surgery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 hours after the surgery

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours after the surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Secondary outcome measures

Complications

Intensity of the postoperative pain

Pain levels

+5 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Para-Sartorial Compartment (PACS) Block + Femoral Triangle Block (FTB) + IPACK blockExperimental Treatment3 Interventions

In addition to the injection performed in the femoral triangle, two injections of 5 mL of 0.5% ropivacaine + epi 1:400 000 will be performed below the sartorius muscle (subsartorial compartment) and above the sartorius muscle (suprasartorial compartment). For all patients, an infiltration between popliteal artery and capsule of the knee block (IPACK) will be performed concomitantly, in order to block the sensory branches of the innervation posterior to the knee with 15 ml of ropivacaine 0.3% + epi 1:400 000.

Group II: Femoral Triangle Block (FTB) + IPACK blockActive Control2 Interventions

This block is currently the most used in practice and is considered a standard of care. It consists of a single injection of 15 ml of 0.5% ropivacaine + epi 1:400 000 under the sartorius muscle, lateral to the femoral artery, at the level of the apex of the femoral triangle For all patients, an infiltration between popliteal artery and capsule of the knee block (IPACK) will be performed concomitantly, in order to block the sensory branches of the innervation posterior to the knee with 15 ml of ropivacaine 0.3% + epi 1:400 000.

0 / 1Eligibility criteria met

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Who is running the clinical trial?

Centre hospitalier de l'Université de Montréal (CHUM)Lead Sponsor

366 Previous Clinical Trials

129,515 Total Patients Enrolled

6 Trials studying Postoperative Pain

554 Patients Enrolled for Postoperative Pain

Maxim Roy, MD, FRCPCPrincipal InvestigatorCentre hospitalier de l'Université de Montréal (CHUM)

1 Previous Clinical Trials

134 Total Patients Enrolled

1 Trials studying Postoperative Pain

134 Patients Enrolled for Postoperative Pain

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still opportunities for people to join this clinical experiment?

"Data hosted on clinicaltrials.gov reveals that the trial, first posted October 1st 2023, is no longer seeking patient enrolment at this time. However, there are 565 other trials currently open for recruitment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Evaluation of the Analgesic Benefit of Adding the Blocks of the Intermediate and Medial Femoral Cutaneous Nerves in Addition to the Femoral Triangle Block for Postoperative Analgesia After a Knee Replacement Surgery

2023. "Evaluation of the Analgesic Benefit of Adding the Blocks of the Intermediate and Medial Femoral Cutaneous Nerves in Addition to the Femoral Triangle Block for Postoperative Analgesia After a Knee Replacement Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06038851.