Ceftriaxone for Meniscus Tears

Phase-Based Progress Estimates
University of Kentucky, Lexington, KYMeniscus Tears+2 MoreCeftriaxone - Drug
18 - 55
All Sexes
What conditions do you have?

Study Summary

This trial will test if a ceftriaxone injection can reduce pain and narcotic use after knee surgery for cartilage or meniscus damage.

Eligible Conditions
  • Meniscal Injury
  • Meniscus Tears
  • Cartilage Injury

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

3 Primary · 0 Secondary · Reporting Duration: Pre-operative, 2 months post-operative

5-12 days post-operative
Post-operative narcotic use
Pre-operative, 2 months post-operative
Change in RU SATED score
Change in Visual analog scale (VAS) pain score

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Side Effects for

12%Decompensated cirrhosis
6%Pruritus with rash
6%Possible gastrointestinal bleed
6%Hepatic Failure
6%Rectus sheath hematoma
6%Hepatic Encephalopathy
This histogram enumerates side effects from a completed 2021 Phase 4 trial (NCT04218695) in the Treatment ARM group. Side effects include: Decompensated cirrhosis with 12%, Nausea with 6%, Pruritus with rash with 6%, Possible gastrointestinal bleed with 6%, hyperkalemia with 6%.

Trial Design

2 Treatment Groups

1 of 2
1 of 2

Experimental Treatment

Non-Treatment Group

48 Total Participants · 2 Treatment Groups

Primary Treatment: Ceftriaxone · Has Placebo Group · Phase 2

Experimental Group · 1 Intervention: Ceftriaxone · Intervention Types: Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Other
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: pre-operative, 2 months post-operative

Who is running the clinical trial?

Austin V StoneLead Sponsor
4 Previous Clinical Trials
74 Total Patients Enrolled
2 Trials studying Meniscus Tears
68 Patients Enrolled for Meniscus Tears
Austin V Stone, MD, PhDPrincipal InvestigatorUniversity of Kentucky

Eligibility Criteria

Age 18 - 55 · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You need a knee surgery for a cartilage or meniscus issue.

Who else is applying?

What state do they live in?
How old are they?
18 - 65100.0%
What site did they apply to?
University of Kentucky100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

Frequently Asked Questions

Who does this study hope to enroll in their test groups?

"Eligible patients for this study must have a meniscus lesion and be between 18-55 years old. Currently, the trial is looking to recruit 48 individuals that fit these requirements." - Anonymous Online Contributor

Unverified Answer

Is this a clinical study that only elderly patients can participate in?

"Individuals aged 18 to 55 may be eligible for this trial, as specified by the eligibility criteria. In comparison, there are 35 trials specifically for minors and 307 trials available for patients over 65 years old." - Anonymous Online Contributor

Unverified Answer

Are there any know side-effects to taking Ceftriaxone?

"Ceftriaxone's safety is based on Phase 2 trial data, meaning that there is evidence that it does not cause harm but no indication of whether or not it is effective." - Anonymous Online Contributor

Unverified Answer

What infections does Ceftriaxone help cure?

"Ceftriaxone is commonly used to treat sepsis bacterial. This medication can also be useful in treating other conditions like complicated urinary tract infections, postoperative infection prevention, and various types of bacterial infections." - Anonymous Online Contributor

Unverified Answer

Are recruitment efforts ongoing for this experiment?

"The listed clinical trial on clinicaltrials.gov is presently recruiting patients. This specific experiment was originally made public on December 28th, 2021 with the latest update occurring January 10th, 2022." - Anonymous Online Contributor

Unverified Answer

How large is the sample size for this experiment?

"That is correct, the clinical trial indicated on clinicaltrials.gov is recruiting patients. The original posting was on December 8th, 2021 and was last updated January 10th, 2022. They are looking for a total of 48 participants between 1 site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.