Meniscus Root Repair for Meniscus Tears

Recruiting at 1 trial location

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Mayo Clinic

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: Surgical procedure

55 Participants Needed

Trial Summary

What is the purpose of this trial?

The results of this study will optimize the care for patients with a meniscus root tear. Surgeons will be able to determine if MRR (meniscus root repair) with transtibial pullout technique is an effective treatment and will identify potential risk factors for poor clinical outcomes. In addition, investigators will determine if MRR is successful in delaying the radiographic progression of arthritis in the involved compartment.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Transtibial pullout technique for meniscus tears?

Research shows that the transtibial pullout technique can lead to beneficial outcomes for patients with meniscus tears, with some studies indicating promising short-term results and good healing observed in follow-up examinations. ^{1 2 3 4 5}

Is the transtibial pullout technique for meniscus root repair generally safe for humans?

The transtibial pullout technique for meniscus root repair has shown promising short-term clinical outcomes and healing in some cases, but there are concerns about poor healing and meniscal extrusion (displacement of the meniscus) in certain situations. Overall, it appears to be generally safe, but the stability of the repair can affect outcomes. ^{1 2 4 5 6}

How does the transtibial pullout technique treatment for meniscus tears differ from other treatments?

The transtibial pullout technique is unique because it involves using sutures to reattach the meniscus root to its original position through a tunnel in the tibia (shinbone), aiming to restore normal knee mechanics. This method is particularly noted for its ability to restore contact mechanics similar to an intact knee, although it can be technically challenging and may result in some displacement during healing. ^{1 3 5 6 7}

Research Team

Daniel Saris, MD

Principal Investigator

Mayo Clinic

Eligibility Criteria

This trial is for individuals aged 18-65 with a specific type of knee injury called meniscus root avulsion tear. It's suitable even if they have other ligament injuries or need bone alignment correction. However, it's not for those who are very obese (BMI over 40), have advanced arthritis (Kellgren Lawrence > grade 2), are on worker's compensation, or have certain severe knee conditions noted in pre-op assessments.

Inclusion Criteria

Meniscus root avulsion tear (defined as meniscus posterior horn root avulsion or full thickness tear within 9 mm of the root attachment)

Age 18-65

It is okay if you have undergone a corrective surgery for bone misalignment.

Exclusion Criteria

Obesity with BMI over 40

Kellgren Lawrence > grade 2

Worker's compensation status

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo meniscus root repair using a transtibial pullout technique

Surgical procedure

Follow-up

Participants are monitored for clinical and radiographic outcomes after the surgical procedure

2 years

Treatment Details

Interventions

• Transtibial pullout technique

Trial Overview Surgeons in this study will use the transtibial pullout technique to repair meniscus root tears and evaluate its effectiveness. They aim to see if this method can delay arthritis progression in the affected area and identify factors that might predict less favorable outcomes.

Participant Groups

Group I: Transtibial pullout technique Experimental Treatment 1 Intervention

Evaluation of the clinical and radiographic outcomes for patients undergoing a meniscus root repair (MRR) using a transtibial pullout technique.

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3,427

Recruited

3,221,000+

References

1. Japan pubmed.ncbi.nlm.nih.gov

The stability of repaired meniscal root can affect postoperative cartilage status following medial meniscus posterior root repair. [2023]

2. United States pubmed.ncbi.nlm.nih.gov

Prospective Consecutive Clinical Outcomes After Transtibial Root Repair for Posterior Meniscal Root Tears: A Multicenter Study. [2022]

3. Germany pubmed.ncbi.nlm.nih.gov

Biomechanical evaluation of meniscal root repair: a porcine study. [2021]

4. United States pubmed.ncbi.nlm.nih.gov

Posterior Meniscal Root Repairs: Outcomes of an Anatomic Transtibial Pull-Out Technique. [2022]

5. United States pubmed.ncbi.nlm.nih.gov

A Modified Transtibial Pull-Out Repair for Posterior Root Avulsions of the Lateral Meniscus with Concomitant Anterior Cruciate Ligament Reconstruction: A Report of Two Cases. [2021]

6. United States pubmed.ncbi.nlm.nih.gov

Biomechanical evaluation of a transtibial pull-out meniscal root repair: challenging the bungee effect. [2018]

7. Germany pubmed.ncbi.nlm.nih.gov

Biomechanical comparison of meniscus-suture constructs for pullout repair of medial meniscus posterior root tears. [2020]