AM3101 for Meniscus Tears
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests AM3101, a treatment for knee injuries, on patients with meniscal tears needing repair. It aims to help the knee tissue heal better after surgery, reducing complications.
Will I have to stop taking my current medications?
If you are currently taking simvastatin or any other statin drugs, you will need to stop taking them to participate in this trial.
Who Is on the Research Team?
Brian M Grawe, MD
Principal Investigator
University of Cincinnati
Are You a Good Fit for This Trial?
This trial is for men and women aged 18-40 with MRI evidence of a meniscus tear, either alone or with an ACL tear. Participants must have a BMI ≤ 40 kg/m2, normal liver and kidney function, and be able to follow the study's procedures. Exclusions include severe arthritis, other ligament injuries requiring surgery (except ACL), recent drug/alcohol dependence, current statin use or allergy to simvastatin.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either AM3101 or a saline solution following meniscal repair
Follow-up
Participants are monitored for safety and effectiveness after treatment, including MRI assessments
What Are the Treatments Tested in This Trial?
Interventions
- AM3101
- Saline Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Cincinnati
Lead Sponsor
United States Department of Defense
Collaborator