Transcranial magnetic stimulation for Depression

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Depression+2 MoreTranscranial magnetic stimulation - Procedure
Eligibility
18 - 65
All Sexes
What conditions do you have?
Select

Study Summary

This trial will compare two different ways of using transcranial magnetic stimulation to treat people with major depressive disorder. The goal is to see if one method is better than the other at treating both depression and anxiety.

Eligible Conditions
  • Depression
  • Anxiety

Treatment Effectiveness

Study Objectives

2 Primary · 6 Secondary · Reporting Duration: Baseline (before treatment), 3 weeks (after 15 treatments), and 6 weeks (after 30 treatments)

Week 6
Multidimensional battery of emotional questionnaires
Multidimensional task-based emotional assessment
NIH Toolbox cognitive battery
Pain at the stimulation site
Resting-state functional MRI (rsfMRI) scan
Temperament and Character Inventory, Revised 140-item (TCI-R 140)
Week 6
Anxiety
Mental Depression

Trial Safety

Trial Design

2 Treatment Groups

Dysphoric target
1 of 2
Anxiosomatic target
1 of 2

Experimental Treatment

40 Total Participants · 2 Treatment Groups

Primary Treatment: Transcranial magnetic stimulation · No Placebo Group · Phase 2

Dysphoric target
Procedure
Experimental Group · 1 Intervention: Transcranial magnetic stimulation · Intervention Types: Procedure
Anxiosomatic target
Procedure
Experimental Group · 1 Intervention: Transcranial magnetic stimulation · Intervention Types: Procedure
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial magnetic stimulation
2015
Completed Phase 4
~430

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline (before treatment), 3 weeks (after 15 treatments), and 6 weeks (after 30 treatments)

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor
1,480 Previous Clinical Trials
9,735,789 Total Patients Enrolled
21 Trials studying Depression
120,099 Patients Enrolled for Depression
Shan H Siddiqi, MDPrincipal InvestigatorBrigham and Women's Hospital
1 Previous Clinical Trials
15 Total Patients Enrolled

Eligibility Criteria

Age 18 - 65 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You must be age 18 to 65.
You have a major depressive disorder and have failed at least one antidepressant trial

Who else is applying?

What state do they live in?
Massachusetts100.0%
How old are they?
65+50.0%
18 - 6550.0%
What site did they apply to?
Brigham & Women's Hospital100.0%
What portion of applicants met pre-screening criteria?
Did not meet criteria50.0%
Met criteria50.0%