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Behavioural Intervention

Brain Stimulation Techniques for Depression

N/A

Waitlist Available

Led By Sheldon E Jordan, M.D.

Research Sponsored by Neurological Associates of West Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

At least 18 years of age

Failure to remit with 3 antidepressants

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 months

Awards & highlights

Study Summary

This trial will compare the effects of two types of brain stimulation on depression.

Who is the study for?

This trial is for adults with major depressive disorder who haven't improved after trying three antidepressants. Participants must be over 18, speak English, and score above 13 on the Beck Depression Inventory. It's not for those with active cancer, recent surgery, metal implants near the head, or certain blood diseases.Check my eligibility

What is being tested?

The study compares two depression treatments: Transcranial Magnetic Stimulation (TMS) and intermittent Theta Burst Stimulation (iTBS). The goal is to see which one works better at improving symptoms of major depressive disorder.See study design

What are the potential side effects?

Potential side effects may include discomfort at the stimulation site, headache, lightheadedness, tingling or spasms in facial muscles. Rarely it could cause seizures or hearing loss if proper ear protection isn't used.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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I have tried 3 antidepressants without improvement.

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I have been diagnosed with Major Depressive Disorder.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Secondary outcome measures

Beck Depression Inventory (BDI-II)

Global Rating of Change (GRC)

Hamilton Depression Rating Scale (HAM-D)

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: Transcranial Magnetic StimulationExperimental Treatment1 Intervention

All patients are required to have an advanced MRI of the brain including a structural T1, volume measurements of various brain regions, ASL, and BOLD sequences. Patients will also undergo an in-scanner task designed to activate key neurofunctional regions of interest.

Group II: Theta Burst StimulationExperimental Treatment1 Intervention

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Transcranial Magnetic Stimulation

2017

Completed Phase 4

~730

Theta Burst Stimulation

2014

N/A

~140

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Neurological Associates of West Los AngelesLead Sponsor

25 Previous Clinical Trials

3,930 Total Patients Enrolled

4 Trials studying Depression

800 Patients Enrolled for Depression

Sheldon E Jordan, M.D.Principal InvestigatorNeurological Associates of West Los Angeles

2 Previous Clinical Trials

127 Total Patients Enrolled

Media Library

Theta Burst Stimulation (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04497350 — N/A

Depression Research Study Groups: Transcranial Magnetic Stimulation, Theta Burst Stimulation

Depression Clinical Trial 2023: Theta Burst Stimulation Highlights & Side Effects. Trial Name: NCT04497350 — N/A

Theta Burst Stimulation (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04497350 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the study open to participants over the age of 45?

"The prerequisites for individuals enrolling in this trial are aged between 18 and 70. An additional 193 studies have been developed to accommodate patients younger than 18 while 968 exist specifically for those above 65 years old."

Answered by AI

Are there currently any openings in this clinical trial?

"This medical study does not appear to be enrolling patients at this time, as per the details on clinicaltrials.gov. The trial was initially posted in January of 2020 and last updated in September of 2022. Nevertheless, there are 1296 other studies actively seeking participants currently."

Answered by AI

Who would be qualified to join this investigation?

"For this trial, 30 individuals with Major Depressive Disorder (mdd) aged from 18 to 70 are being recruited. The essential prerequisites for participation include: a confirmed diagnosis of mdd; a Beck Depression Inventory score higher than 13; unsuccessful treatment using three antidepressants; the age of majority or older; agreement to comply with all study protocols and sufficient knowledge of English."

Answered by AI