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Neuromodulation
TMS for Depression (TMS-LLD Trial)
N/A
Recruiting
Research Sponsored by University of New Mexico
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 3 post-treatment assessment
Awards & highlights
TMS-LLD Trial Summary
This trialstudies new ways to make TMS, a treatment for late-life depression, more effective using fMRI.
Who is the study for?
This trial is for English-speaking individuals aged 60-79 with major depressive disorder diagnosed by a psychiatrist, currently experiencing a depressive episode. Excluded are pregnant women, those with bipolar or psychotic disorders, recent hospitalization, neurosurgery history, ECT in the last three months, MRI contraindications, substance abuse within three months, seizure history or neurological disorders.Check my eligibility
What is being tested?
The study tests how to improve transcranial magnetic stimulation (TMS), an existing treatment for late-life depression. It uses fMRI to personalize TMS targeting and assess its effectiveness in an open-label setting where all participants receive the intervention.See study design
What are the potential side effects?
While not specified here, common side effects of rTMS may include headache or scalp discomfort at the site of stimulation. Rarely it can cause seizures or hearing loss if ear protection isn't used during treatment.
TMS-LLD Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ week 3 post-treatment assessment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 3 post-treatment assessment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Anterior Cingulate Cortex (ACC) Connectivity
Secondary outcome measures
Depression Severity
TMS-LLD Trial Design
1Treatment groups
Experimental Treatment
Group I: rTMSExperimental Treatment1 Intervention
Subjects will receive rTMS to the area of the DLPFC most anticorrelated with the ACC.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
rTMS
2016
Completed Phase 3
~840
Find a Location
Who is running the clinical trial?
The Mind Research NetworkOTHER
26 Previous Clinical Trials
2,476 Total Patients Enrolled
1 Trials studying Depression
62 Patients Enrolled for Depression
University of New MexicoLead Sponsor
372 Previous Clinical Trials
3,528,765 Total Patients Enrolled
14 Trials studying Depression
2,848 Patients Enrolled for Depression
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I have had TMS treatment before.I have not had ECT treatment in the last 3 months.I have been diagnosed with a neurological or neurocognitive disorder.I have been diagnosed with major depression without psychosis by a psychiatrist.I am legally and mentally able to consent to the study.I have not been hospitalized nor had a severe illness in the last 3 weeks.I can attend all study visits and sessions on my own and on time.I have had seizures in the past.I have been diagnosed with a mental health condition like bipolar disorder or schizophrenia.I have had brain surgery before.I am between 60 and 79 years old.I have not used substances I'm addicted to in the last 3 months.
Research Study Groups:
This trial has the following groups:- Group 1: rTMS
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is there any eligibility criteria which would preclude me from participating in this experiment?
"To participate in this trial, participants must be aged between 60 and 79 with a diagnosed case of depression. A total of 24 volunteers are needed to complete the clinical trial."
Answered by AI
Are there still available opportunities for individuals to join this experiment?
"Clinicaltrials.gov data conveys that, as of October 26th 2022, this clinical trial is looking for more patients to participate. This study was initially made public on October 1st 2020."
Answered by AI
How many participants are being accepted into this medical research endeavor?
"Yes, per the information on clinicaltrials.gov this trial is actively seeking participants and was first posted in October of 2020 with a recent update as of October 26th 2022. This study requires 24 patients to be recruited from one location."
Answered by AI
Can participants who are 18 years of age or older take part in this examination?
"In keeping with the trial's prerequisites, applicants must be between 60 and 79 years of age."
Answered by AI
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