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taVNS + TMS for Depression
Study Summary
This trial tests combining two treatments—nerve stimulation & magnetic stimulation—to treat depression better than either one alone. In-person at MUSC in Charleston, SC.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- I need a legal guardian to make decisions for me due to cognitive issues.I am between 18 and 75 years old.I am receiving VNS for my neck or have tried two antidepressants without success.I can speak, read, and write in English.Talking therapy hasn't improved my condition.
- Group 1: Vagus Nerve Stimulation (VNS) only
- Group 2: Transcranial Magnetic Stimulation (TMS) only
- Group 3: Synchronized VNS and TMS
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many individuals are volunteering for this experiment?
"Affirmative. On clinicaltrials.gov, the trial is listed as actively recruiting with an original posting date of March 14th 2023 and a most recent edit on April 30th 2023. The study needs 24 volunteers from 1 site to reach its quota of participants."
Are there currently any openings available for participants of this research?
"As per the details provided on clinicaltrials.gov, this research project is actively searching for volunteers to partake in their experiment. It was introduced on March 14th 2023 and edited most recently at the end of April 2023."
Is the age requirement for participation in this trial eighteen years or older?
"This trial is only open to those aged 18-75; if a patient falls outside of this age range, there are 206 trials for younger patients and 991 clinical studies for seniors."
Who is eligible to enroll in this research?
"This trial is seeking 24 participants with depression, aged between 18 and 75. The ideal candidate must fulfill the following criteria: be within this age range, have either undergone cervical VNS or tried two failed antidepressant medications in their current episode, provide informed consent; demonstrate English literacy and comprehension of written materials; score a 17-item Hamilton Depression Rating Scale (HAM-D) result of at least 20 points; show no response to talking therapy."
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