Mango Consumption for Prediabetes
(MG3 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how eating mangoes affects individuals at risk of developing diabetes. Researchers aim to determine the impact of mangoes on blood sugar and inflammation when consumed before, with, or after meals. Participants will be divided into groups: one will eat mango before breakfast, another with breakfast, and another after breakfast, while a control group will not consume mango. This trial suits non-smokers diagnosed with prediabetes (slightly high blood sugar) who can adhere to study guidelines. As an unphased trial, participants have the opportunity to contribute to groundbreaking research on dietary impacts on prediabetes.
Will I have to stop taking my current medications?
The trial requires that you do not take medications or supplements that could interfere with the study, so you may need to stop some of your current medications. It's best to discuss this with the trial team to see if your specific medications are allowed.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that eating mangoes is generally safe. Studies have found that consuming mangoes daily for several weeks can improve insulin use, aiding in blood sugar control. One study found that eating fresh mango can increase satiety and help manage blood sugar after meals.
Mangoes, as a natural fruit, are usually well-tolerated, with no major reports of adverse reactions when consumed in normal amounts. However, some individuals might experience allergies or sensitivities. For most, eating a cup of mango before, with, or after breakfast appears safe based on current research.12345Why are researchers excited about this trial's treatments?
Unlike standard treatments for prediabetes, which often include medications like metformin or lifestyle changes, this approach uses mango, a common fruit, as a potential intervention. Mango is unique because it's rich in bioactive compounds like polyphenols, which may help regulate blood sugar levels naturally. Researchers are particularly interested in the timing of mango consumption—before, with, or after a meal—to see how it affects glucose metabolism. This natural approach might offer a simpler, diet-based alternative to traditional medications, potentially with fewer side effects.
What evidence suggests that mango consumption might be an effective treatment for prediabetes?
This trial will evaluate the effects of mango consumption on blood sugar levels in individuals with prediabetes. Participants will be assigned to different groups: some will consume mango before, with, or after a standardized breakfast, while others will receive a control beverage with their meal. Research has shown that eating mangoes might help control blood sugar levels in people at risk of diabetes. Specifically, one study found that people who ate a mango every day for 24 weeks had lower morning blood sugar levels compared to those who didn't eat mangoes. Another study discovered that daily mango consumption helped control blood sugar and improved the body's ability to use sugar. Mangoes were also more effective at improving early signs of diabetes than low-sugar granola bars. These findings suggest that mangoes could be helpful for people trying to manage early signs of diabetes.46789
Who Is on the Research Team?
Indika Edirisinghe, PhD.
Principal Investigator
Illinois Institute of Technology
Britt Burton-Freeman, PhD.
Principal Investigator
Illinois Institute of Technology
Are You a Good Fit for This Trial?
This trial is for adults aged 20-60 with a BMI of 25-35, prediabetic blood sugar levels, and no major diseases. Participants must not smoke or take conflicting medications and should be able to adhere to the study's diet and visit schedule. Pregnant individuals, those on extreme diets, or with recent significant weight changes are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-Study
Participants receive detailed instructions on study procedures and preparation
Treatment
Participants consume mango or control beverage relative to meals over four study-day visits
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Mango
Find a Clinic Near You
Who Is Running the Clinical Trial?
Clinical Nutrition Research Center, Illinois Institute of Technology
Lead Sponsor
National Mango Board
Collaborator