Your session is about to expire
← Back to Search
Mitochondrial Targeted Antioxidant
MitoQ for Asthma (MIMDA Trial)
Phase 1
Recruiting
Led By Anne E Dixon, MD
Research Sponsored by University of Vermont
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Poorly controlled asthma defined as one of the following: Asthma Control Test5 Score ≤ 19 (at visit 1), or Participant reported use of rescue inhaler on average > 2 uses/week for preceding month, or Participant reported nocturnal asthma awakening on average 1 or more times / week in preceding month, or Participant reported ED/hospital visit or prednisone course for asthma in past six months
Participant reported physician diagnosis of asthma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, 12 weeks
Awards & highlights
MIMDA Trial Summary
This trial will test whether the supplement Mitoquinol can help improve asthma symptoms in obese patients.
Who is the study for?
This trial is for obese adults with poorly controlled asthma, diagnosed by a physician and on regular therapy. They must have reactive airways as shown by tests, use their rescue inhaler frequently or have had recent severe symptoms or treatment. Smokers, pregnant women, those using certain drugs or with other significant diseases are excluded.Check my eligibility
What is being tested?
The study compares Mitoquinol (MitoQ), an antioxidant supplement, to a placebo over 14 weeks to see if it improves lung function in obese patients with asthma. It's randomized and double-masked so neither the participants nor researchers know who gets what until the end.See study design
What are the potential side effects?
While specific side effects of MitoQ aren't listed here, antioxidants like MitoQ can sometimes cause digestive discomfort, allergic reactions, or headaches. The exact side effects will be monitored throughout the trial.
MIMDA Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My asthma is not well-controlled, based on symptoms or recent emergency care.
Select...
I have been diagnosed with asthma by a doctor.
Select...
I am 18 years old or older.
MIMDA Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ through study completion, 12 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, 12 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
change in airway reactivity
Secondary outcome measures
Adherence
Adverse effects
Asthma Control Test (ACT)
+7 moreMIMDA Trial Design
2Treatment groups
Active Control
Placebo Group
Group I: MitoQActive Control1 Intervention
MitoQ 40 mg per day for 12 weeks
Group II: PlaceboPlacebo Group1 Intervention
placebo daily for 12 weeks
Find a Location
Who is running the clinical trial?
University of VermontLead Sponsor
267 Previous Clinical Trials
3,743,701 Total Patients Enrolled
9 Trials studying Asthma
4,729 Patients Enrolled for Asthma
Duke UniversityOTHER
2,363 Previous Clinical Trials
3,420,446 Total Patients Enrolled
21 Trials studying Asthma
55,212 Patients Enrolled for Asthma
Anne E Dixon, MDPrincipal InvestigatorUniversity of Vermont
1 Previous Clinical Trials
28 Total Patients Enrolled
1 Trials studying Asthma
28 Patients Enrolled for Asthma
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I had sinus surgery less than 4 weeks ago.My asthma is not well-controlled, based on symptoms or recent emergency care.I have been diagnosed with COPD by a doctor.I have been on prescribed asthma control medication for over 3 months.Your lung function is below a certain level.You have smoked cigarettes, cigars, or pipes in the past 6 months.I agree to use effective birth control during the study.I often have severe nosebleeds.You use a vaping device more than twice a week.I had eye surgery in the last 3 months.You have a positive test for methacholine challenge, which means your airways are more reactive than normal.You use e-cigarettes more than twice a week.I have been treated for an asthma attack in the last 4 weeks.I have smoked more than 10 packs of cigarettes a year.I have used idebenone or co-enzyme Q10 in the last 8 weeks.I have been diagnosed with asthma by a doctor.You use marijuana by smoking it more than twice a week.You have a body mass index (BMI) of 30 or higher.I am 18 years old or older.
Research Study Groups:
This trial has the following groups:- Group 1: MitoQ
- Group 2: Placebo
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the scale of enrollment for this scientific experiment?
"Affirmative. Research published on clinicaltrials.gov confirms that this medical trial is actively recruiting participants; the initiative was first posted in January 1st 2020 and most recently updated on January 21st 2022, with a total of 40 patients sought from 2 sites."
Answered by AI
Does MitoQ pose any risks to human health?
"Evaluators at Power assigned MitoQ a score of 1, as the compound has only undergone Phase 1 testing and thus limited data regarding efficacy and safety are available."
Answered by AI
Is recruitment for this research opportunity still open?
"According to the data presented on clinicaltrials.gov, this medical research is actively recruiting patients. It was initially posted on January 1st 2020 and has been amended most recently on January 21st 2022."
Answered by AI
What other research attempts have been undertaken with the utilization of MitoQ?
"MitoQ was initially studied at George E Wahlen VA Medical Center in 2008, since then 68 trials have been completed. Currently, 4 active clinical studies are taking place predominantly based out of Durham, North carolina."
Answered by AI
Recent research and studies
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger