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Probiotics

Probiotics for Obese Asthmatics with Insulin Resistance

N/A

Waitlist Available

Led By Jessy Deshane, PhD

Research Sponsored by University of Alabama at Birmingham

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age > 18 years

All patients will be obese asthmatics with a body mass index >30 and insulin resistance >5

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 weeks

Awards & highlights

Study Summary

This trial will test if oral probiotics help improve asthma symptoms in obese insulin resistant people.

Who is the study for?

This trial is for obese adults over 18 with asthma and insulin resistance. Participants must have a BMI >30, stable asthma without medication changes for 3 months, and an insulin resistance score >5. It's not open to pregnant individuals or those who can't consent, have had recent severe asthma attacks or other lung diseases.Check my eligibility

What is being tested?

The study tests if oral probiotics can change the airway microbiome/metabolome in these patients, reduce leptin and insulin resistance levels, lead to weight loss, and improve asthma outcomes compared to a placebo.See study design

What are the potential side effects?

While specific side effects are not listed here, probiotics are generally considered safe but may cause digestive discomfort such as gas or bloating in some people.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am older than 18 years.

Select...

I am obese with a BMI over 30 and have insulin resistance greater than 5.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Determine if microbiome/metabolome changes in probiotics group correlates with changes in asthma biomarkers and improved clinical outcomes compared to placebo in obese insulin resistant asthmatics

Determine if modulation of leptin levels and insulin sensitivity by probiotics administration correlates with airway metabolome alterations and weight loss in obese insulin resistant asthmatics

Determine if probiotic administration modulates airway microbiome/metabolome in obese insulin resistant asthmatics

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: ProbioticExperimental Treatment1 Intervention

Subjects will receive a probiotic supplement to take by mouth daily.

Group II: PlaceboPlacebo Group1 Intervention

Subjects will receive a placebo to take by mouth daily.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Probiotic

2013

Completed Phase 4

~3570

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor

1,583 Previous Clinical Trials

2,280,024 Total Patients Enrolled

5 Trials studying Asthma

40,959 Patients Enrolled for Asthma

American Lung AssociationOTHER

31 Previous Clinical Trials

10,953 Total Patients Enrolled

13 Trials studying Asthma

3,379 Patients Enrolled for Asthma

Jessy Deshane, PhDPrincipal InvestigatorUniversity of Alabama at Birmingham

Media Library

Probiotic (Probiotics) Clinical Trial Eligibility Overview. Trial Name: NCT05949255 — N/A

Asthma Research Study Groups: Probiotic, Placebo

Asthma Clinical Trial 2023: Probiotic Highlights & Side Effects. Trial Name: NCT05949255 — N/A

Probiotic (Probiotics) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05949255 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Would I be eligible to partake in this experiment?

"Candidates aged 18 to 99 years old, who possess insulin resistance, are eligible for this medical test. Twenty participants will be taken into consideration."

Answered by AI

Does this research study have an age restriction, and if so, what is it?

"Participants in this medical trial need to be aged 18 or older, yet not more than 99 years old."

Answered by AI

Are there still openings for this experiment?

"After consulting clinicaltrials.gov, it is clear that this particular medical study has stopped recruiting as of July 7th 2023; its initial posting was on 15/7/2023. Fortunately, there are 1435 other trials actively calling for volunteers at the moment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Probiotics and Insulin Resistance in Obese Asthmatics

Jessy S. Deshane 2024. "Probiotics and Insulin Resistance in Obese Asthmatics". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05949255.

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