Clinical TrialsClinical Trials in Knoxville, TN
Reviewed by Michael Gill, B. Sc.
Image of DaVita Inglewood Dialysis in Inglewood, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

PF-07321332 (nirmatrelvir)/ritonavir Participants With Severe Renal Impairment On Hemodialysisfor COVID19 (disease)

18+
All Sexes
The purpose of this study is to learn about the side effects (safety) of the study medicine PF-07321332 (nirmatrelvir)/ritonavir for the treatment of mild to moderate COVID-19 infection in adults with severe renal impairment. The study will also look at the amounts of study drug in your blood. There will be 24 participants in this study; 12 of them will have severe renal impairment and not be on hemodialysis and 12 of them will be on hemodialysis. All participants in this study will take PF-07321332 (nirmatrelvir)/ritonavir by mouth for 5 days. During this time, they will have to collect blood samples to measure the study drug levels in their blood. After taking the study drug for 5 days, the participants will have follow-up visits for about another 28 days for a total of about 34 days in the study. The study team will check how each participant is doing during regular visits at the study clinic.
Phase 1
Recruiting
DaVita Inglewood Dialysis (+36 Sites)Pfizer CT.gov Call CenterPfizer
Image of University of Tennessee Medical Center in Knoxville, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

AD Patientsfor Alzheimer Disease

18+
All Sexes
The purpose of the study is to investigate the efficacy of cortical gamma oscillation on visual sensory processing and cognitive function in Alzheimer's Disease (AD) patients by combining a therapeutic sensory stimulation device capable of evoking 40-Hz gamma oscillation via non-invasive visual and auditory stimulation with pre-established markers of cortical network activity, i.e., electroencephalography (EEG) and event-related potentials (ERP), to evaluate the applicability of the 40-Hz multimodel sensory stimulation as a novel therapeutic approach for treatment of AD patients.
Recruiting
Has No Placebo
University of Tennessee Medical CenterRoberto Fernandez-Romero, MD
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