Clinical Trials in Knoxville, TN
View medical research that is recruiting in Knoxville, Tennessee. Filter by phase, distance, and inclusion criteria to find cutting edge treatments & access premium care.
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Clinical Trials
Clinical Trials in Knoxville, TN
Phase-Based Estimates
2
Effectiveness
3
Safety
Thoracotomy
for Cancer
Valhalla, NY
< 65
All Sexes
Phase 3
Recruiting
Metastatic
Valhalla, NY
< 65
All Sexes
This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.
Phase-Based Estimates
1
Effectiveness
1
Safety
124I-AT03
for Amyloidosis
Knoxville, TN
18+
All Sexes
Phase 1
Recruiting
Knoxville, TN
18+
All Sexes
This is a single center Phase 1 study is to evaluate the biodistribution of radiolabeled AT-03 in patients with systemic amyloidosis.
Phase-Based Estimates
1
Effectiveness
2
Safety
Sotatercept
for Hypertension, Pulmonary
Knoxville, TN
18+
All Sexes
Phase 2
Recruiting
Knoxville, TN
18+
All Sexes
This is a Phase 2, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of sotatercept versus placebo in adults with Cpc-PH due to HFpEF. The objective of this study is to evaluate the efficacy, safety and tolerability of sotatercept versus placebo in adults with Cpc-PH due to HFpEF. Efficacy is measured by change from baseline in pulmonary vascular resistance (PVR, primary endpoint) and 6-minute walk distance (6MWD, key secondary endpoint).
Phase-Based Estimates
1
Effectiveness
2
Safety
Tezepelumab Dose 2
for Urticaria
Ann Arbor, MI
18+
All Sexes
Phase 2
Recruiting
Ann Arbor, MI
18+
All Sexes
This study is evaluating whether a drug may help reduce the symptoms of chronic hives.
Phase-Based Estimates
2
Effectiveness
3
Safety
Radiation Therapy
for Lymphoma
Birmingham, AL
Any Age
All Sexes
Phase 3
Recruiting
1 Prior Treatment
Birmingham, AL
Any Age
All Sexes
This study is evaluating whether a new type of treatment for primary mediastinal B-cell lymphoma (PMBCL) is better than standard treatment.
Phase-Based Estimates
2
Effectiveness
3
Safety
Pembrolizumab/Quavonlimab
for Carcinoma
Quebec, Canada
18+
All Sexes
Phase 3
Recruiting
Locally Advanced
Quebec, Canada
18+
All Sexes
The goal of this study is to evaluate the efficacy and safety of pembrolizumab plus belzutifan plus lenvatinib or pembrolizumab/quavonlimab plus lenvatinib versus pembrolizumab plus lenvatinib as first-line treatment in participants with advanced clear cell renal cell carcinoma (ccRCC). The primary hypotheses are (1) pembrolizumab plus belzutifan plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to progression-free survival (PFS) and overall survival (OS), in advanced ccRCC participants and (2) pembrolizumab/quavonlimab plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to PFS and OS, in advanced ccRCC participants.
Phase-Based Estimates
1
Effectiveness
2
Safety
PF-06882961
for Obesity
Memphis, TN
18+
All Sexes
Phase 2
Waitlist Available
Memphis, TN
18+
All Sexes
This study is evaluating whether a drug may help treat obesity.
Phase-Based Estimates
2
Effectiveness
3
Safety
Epcoritamab
for Lymphoma, Large B-Cell, Diffuse
Saint Louis Park, MN
18+
All Sexes
Phase 3
Recruiting
Grade III
Saint Louis Park, MN
18+
All Sexes
This study is evaluating whether a drug called epcoritamab can be used to treat people with relapsed, refractory diffuse large B-Cell Lymphoma.
Phase-Based Estimates
2
Effectiveness
3
Safety
Seladelpar 10 Mg
for Cholangitis
Boston, MA
18+
All Sexes
Phase 3
Recruiting
Boston, MA
18+
All Sexes
This study is evaluating whether a drug called Seladelpar may help treat cholestasis, a condition in which bile is not released from the liver.
Phase-Based Estimates
2
Effectiveness
3
Safety
KSI-301
for Macular Edema
Pensacola, FL
18+
All Sexes
Phase 3
Waitlist Available
Newly Diagnosed
Pensacola, FL
18+
All Sexes
This study is evaluating whether a drug may help treat macular edema.
Phase-Based Estimates
1
Effectiveness
2
Safety
Brentuximab Vedotin
for Lymphoma, T-Cell, Peripheral
Austin, TX
18+
All Sexes
Phase 2
Recruiting
Newly Diagnosed
Austin, TX
18+
All Sexes
This study is evaluating whether a combination of drugs may help treat certain types of lymphoma.
Phase-Based Estimates
2
Effectiveness
3
Safety
Ensifentrine
for Airflow Obstruction, Chronic
Clearwater, FL
18+
All Sexes
Phase 3
Waitlist Available
Clearwater, FL
18+
All Sexes
This study is evaluating whether a drug called ensifentrine may help treat COPD.
Phase-Based Estimates
2
Effectiveness
3
Safety
Nivolumab
for Anal Cancer
Parker, CO
18+
All Sexes
Phase 3
Recruiting
Class II
Parker, CO
18+
All Sexes
This study is evaluating whether a combination of chemotherapy and immunotherapy may help treat anal cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
RSVpreF
for Respiratory Tract Infections
Lancaster, CA
< 65
Female
Phase 3
Recruiting
Lancaster, CA
< 65
Female
This study is evaluating whether a vaccine may help prevent infants from getting RSV.
Phase-Based Estimates
1
Effectiveness
2
Safety
Dabrafenib Mesylate
for Glioma
Tampa, FL
< 65
All Sexes
Phase 2
Recruiting
Grade III
Tampa, FL
< 65
All Sexes
This study is evaluating whether a combination of two drugs may help treat children and young adults with high grade glioma.
Phase-Based Estimates
1
Effectiveness
2
Safety
Cabozantinib S-malate
for Prostate Cancer
Farmington, MO
18+
All Sexes
Phase 2
Recruiting
Class III
Farmington, MO
18+
All Sexes
This study is evaluating whether a combination of drugs may help treat patients with rare tumors.
Phase-Based Estimates
2
Effectiveness
3
Safety
Durvalumab
for Carcinoma, Hepatocellular
Spartanburg, SC
18+
All Sexes
Phase 3
Waitlist Available
High Risk
Spartanburg, SC
18+
All Sexes
This study is evaluating whether a combination of two drugs may help treat liver cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
Pemetrexed
for Lung Cancer
Stevens Point, WI
18+
All Sexes
Phase 3
Recruiting
Class II
Stevens Point, WI
18+
All Sexes
This study is evaluating whether a combination of chemotherapy and immunotherapy may be more effective than chemotherapy alone in treating non-small cell lung cancer.
Phase-Based Estimates
1
Effectiveness
2
Safety
Telisotuzumab Vedotin
for Carcinoma, Non-Small-Cell Lung
Knoxville, TN
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Knoxville, TN
18+
All Sexes
This study is evaluating whether a drug may help treat lung cancer.
Phase-Based Estimates
1
Effectiveness
1
Safety
TTI-622
for Multiple Myeloma
Knoxville, TN
18+
All Sexes
Phase 1
Recruiting
Grade I
Knoxville, TN
18+
All Sexes
This study is evaluating whether a drug called TTI-622 may help treat lymphoma or myeloma.
Phase-Based Estimates
1
Effectiveness
1
Safety
Upifitamab Rilsodotin
for Non Small Cell Lung Cancer Metastatic
Providence, RI
18+
All Sexes
Phase 1 & 2
Recruiting
Grade I
Providence, RI
18+
All Sexes
This study is evaluating whether a drug may help treat ovarian cancer.
Phase-Based Estimates
1
Effectiveness
1
Safety
RDirectCAM
for Multiple Sclerosis
Knoxville, TN
18+
All Sexes
Waitlist Available
Knoxville, TN
18+
All Sexes
The purpose of this study is to compare the effects of two delivery models of an evidence-based complementary alternative medicine (CAM) program that combines neurorehabilitative (functional) exercise, yoga, and Pilates for adults age 18-70 with multiple sclerosis (MS). CAM will be delivered as a 12-week program through two different delivery forms: On-site at a clinic (DirectCAM) and telerehabilitation (TeleCAM). Participants will be randomly assigned to one of these two groups. **On March 16th, 2020, the University of Alabama at Birmingham halted all onsite non-essential research in response to the Covid-19 pandemic. Since then, the study has begun to conduct all testing remotely through videoconferencing technology. In addition, another study group, remote DirectCAM (rDirectCAM), has been incorporated into the study to continue the 12-week program delivery for newly recruited participants via videoconferencing technology.**
Phase-Based Estimates
1
Effectiveness
2
Safety
Umbralisib
for Lymphoma, Diffuse
Philadelphia, PA
18+
All Sexes
Phase 2 & 3
Waitlist Available
1 Prior Treatment
Philadelphia, PA
18+
All Sexes
This study is evaluating whether a combination of two drugs may help treat non-Hodgkin's lymphoma.
Phase-Based Estimates
1
Effectiveness
2
Safety
Sargramostim
for Melanoma
Urbana, IL
18+
All Sexes
Phase 2 & 3
Recruiting
Grade III
Urbana, IL
18+
All Sexes
This study is evaluating whether a combination of two immunotherapy drugs and a colony stimulating factor may help treat patients with advanced melanoma.
Phase-Based Estimates
1
Effectiveness
1
Safety
Erlotinib
for Carcinoma, Large Cell
Miami Beach, FL
18+
All Sexes
Recruiting
Locally Advanced
Miami Beach, FL
18+
All Sexes
This study is evaluating whether genetic testing may help determine the best treatment for patients with lung cancer.
Phase-Based Estimates
1
Effectiveness
1
Safety
Tolebrutinib
for Kidney Failure
Knoxville, TN
18+
All Sexes
Phase 1
Recruiting
Knoxville, TN
18+
All Sexes
The purpose of this parallel group, Phase 1, open-label, 2-arm study is to assess the effect of severe (Part A) and moderate (Part B, conditional) renal impairment (RI) on pharmacokinetics (PK), safety and tolerability of tolebrutinib tablets compared with normal renal function, in male and female participants aged 18 to 79 years.
Phase-Based Estimates
2
Effectiveness
3
Safety
Ocrelizumab
for Sclerosis
Newark, NJ
18+
All Sexes
Phase 3
Recruiting
Newark, NJ
18+
All Sexes
This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent study (WA21092, WA21093 or WA25046) are eligible for enrollment in this extension study. Participants who will continue ocrelizumab treatment will receive IMP based on the dosage and administration received at the time of rollover from the Parent study.
Phase-Based Estimates
2
Effectiveness
3
Safety
MR-100A-01
for Contraception
Sandy, UT
Any Age
Female
Phase 3
Recruiting
Sandy, UT
Any Age
Female
Study of the contraceptive efficacy, cycle control, safety, and tolerability of MR-100A-01 in approxmiately 1200 women for up to 13 cycles
Phase-Based Estimates
2
Effectiveness
3
Safety
Quality-of-Life Assessment
for Stage IV Urethral Cancer AJCC v8
Basking Ridge, NJ
18+
All Sexes
Phase 3
Recruiting
Locally Advanced
Basking Ridge, NJ
18+
All Sexes
This phase III trial compares the effect of adding cabozantinib to avelumab versus avelumab alone in treating patients with urothelial cancer that has spread to other places in the body (metastatic). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib and avelumab together may further shrink the cancer or prevent it from returning/progressing.
Phase-Based Estimates
1
Effectiveness
2
Safety
Cisplatin
for Stage IVA Laryngeal Cancer AJCC v8
Lenoir City, TN
18+
All Sexes
Phase 2 & 3
Recruiting
Locally Advanced
Lenoir City, TN
18+
All Sexes
This phase II/III compares the standard therapy (chemotherapy plus cetuximab) versus adding bevacizumab to standard chemotherapy, versus combination of just bevacizumab and atezolizumab in treating patients with head and neck cancer that has spread to other places in the body (metastatic or advanced stage) or has come back after prior treatment (recurrent). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of cancer cells. This may help keep cancer cells from growing. Cisplatin and carboplatin are in a class of chemotherapy medications known as platinum-containing compounds. They work by killing, stopping, or slowing the growth of cancer cells. Docetaxel is in a class of chemotherapy medications called taxanes. It stops cancer cells from growing and dividing and may kill them. The addition of bevacizumab to standard chemotherapy or combination therapy with bevacizumab and atezolizumab may be better than standard chemotherapy plus cetuximab in treating patients with recurrent/metastatic head and neck cancers.
Phase-Based Estimates
2
Effectiveness
3
Safety
Inclisiran Sodium 300 Mg
for Atherosclerotic Cardiovascular Diseases
Monroe, LA
18+
All Sexes
Phase 3
Recruiting
Monroe, LA
18+
All Sexes
Study CKJX839B12302 is a pivotal Phase III trial to evaluate the benefits of inclisiran on major adverse cardiovascular (MACE) events in participants with established cardiovascular disease (CVD).
Phase-Based Estimates
2
Effectiveness
3
Safety
Fluvoxamine
for COVID-19
El Paso, TX
18+
All Sexes
Phase 3
Recruiting
El Paso, TX
18+
All Sexes
This study is evaluating whether a medication may help reduce symptoms of a condition that is not well understood.
Phase-Based Estimates
1
Effectiveness
2
Safety
STP705
for Carcinoma in Situ
Aventura, FL
18+
All Sexes
Phase 2
Recruiting
Aventura, FL
18+
All Sexes
This study is evaluating whether a drug may help treat skin cancer.
Phase-Based Estimates
1
Effectiveness
2
Safety
Canakinumab
for Alzheimer Disease
Fairfax, VA
18+
All Sexes
Phase 2
Recruiting
Fairfax, VA
18+
All Sexes
This study is evaluating whether anti-inflammatory agents can improve cognition in people with early Alzheimer's disease.
Phase-Based Estimates
1
Effectiveness
1
Safety
Impella CP® / Impella CP® With SmartAssist® / Impella 2.5®
for Coronary Artery Disease
Winston-Salem, NC
18+
All Sexes
Recruiting
Winston-Salem, NC
18+
All Sexes
This study is evaluating whether a device which pumps blood from the left ventricle to the aorta may help improve heart function following a heart procedure.
Phase-Based Estimates
2
Effectiveness
3
Safety
2.0 Aflibercept
for Wet Macular Degeneration
Prairie Village, KS
18+
All Sexes
Phase 3
Recruiting
Prairie Village, KS
18+
All Sexes
A 2-year phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.
Phase-Based Estimates
2
Effectiveness
3
Safety
Abemaciclib
for Breast Cancer
Dallas, TX
18+
All Sexes
Phase 3
Waitlist Available
Grade III
Dallas, TX
18+
All Sexes
This study is evaluating whether a drug called abemaciclib may help treat breast cancer.
Phase-Based Estimates
1
Effectiveness
2
Safety
BI 685509
for Diabetic Nephropathies
Chicago, IL
18+
All Sexes
Phase 2
Waitlist Available
Chicago, IL
18+
All Sexes
This study is open to adults with diabetic kidney disease. The purpose of the study is to find out whether a medicine called BI 685509 improves kidney function. Three different doses of BI 685509 are tested in this study. Participants get either one of the three doses of BI 685509 or placebo. It is decided by chance who gets which BI 685509 dose and who gets placebo. Participants take BI 685509 or placebo as tablets 3 times a day. Placebo tablets look like BI 685509 tablets but do not contain any medicine. Participants continue taking their usual medicine for diabetes and kidney disease throughout the study. Participants are in the study for about 7 months. During this time, they visit the study site about 11 times. Where possible, about 6 of the 11 visits can be done at the participant's home instead of the study site. The trial staff may also contact the participants by phone or video call. Kidney function is assessed based on the analysis of urine samples, which participants collect at home. At the end of the trial the results are compared between the different doses of BI 685509 and placebo. During the study, the doctors also regularly check the general health of the participants.
Phase-Based Estimates
1
Effectiveness
2
Safety
IMC-1
for Fibromyalgia
Las Vegas, NV
18+
Female
Phase 2
Waitlist Available
Las Vegas, NV
18+
Female
This study is evaluating whether a drug called IMC-1 may help treat fibromyalgia.
Phase-Based Estimates
1
Effectiveness
2
Safety
Cediranib Maleate
for Ovary Cancer
Glenview, IL
18+
Female
Phase 2
Recruiting
Grade I
Glenview, IL
18+
Female
This study is evaluating whether a combination of drugs may help treat ovarian cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
Radiopaque Etonogestrel (ENG) Implant
for Contraception
Durham, NC
< 65
Female
Phase 3
Recruiting
Durham, NC
< 65
Female
This study is evaluating whether a contraceptive implant may be effective for longer than the currently approved 3 years.
Phase-Based Estimates
2
Effectiveness
3
Safety
SEL-212B
for Gout
Boise, ID
18+
All Sexes
Phase 3
Recruiting
Boise, ID
18+
All Sexes
This study is evaluating whether a drug may help reduce the size of tophi in individuals with gout.
Phase-Based Estimates
2
Effectiveness
3
Safety
Sacituzumab Govitecan-hziy
for Locally Advanced or Metastatic Unresectable Urothelial Cancer
Hershey, PA
18+
All Sexes
Phase 3
Recruiting
Class III
Hershey, PA
18+
All Sexes
The primary objective of this study is to assess overall survival (OS) with sacituzumab govitecan-hziy in comparison with treatment of physician's choice (TPC) in participants with metastatic or locally advanced unresectable urothelial cancer (UC).
Phase-Based Estimates
2
Effectiveness
3
Safety
Tolebrutinib
for Sclerosis
Charlotte, NC
18 - 65
All Sexes
Phase 3
Recruiting
1 Prior Treatment
Charlotte, NC
18 - 65
All Sexes
Primary Objective: To assess efficacy of daily SAR442168 compared to a daily dose of 14 mg teriflunomide (Aubagio) measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS Secondary Objective: To assess efficacy of SAR442168 compared to teriflunomide (Aubagio) on disability progression, MRI lesions, cognitive performance and quality of life To evaluate the safety and tolerability of daily SAR442168 To evaluate pharmacodynamics (PD) of SAR442168
Phase-Based Estimates
2
Effectiveness
3
Safety
Cisplatin
for Lung Cancer
West Mifflin, PA
18+
All Sexes
Phase 3
Recruiting
Grade III
West Mifflin, PA
18+
All Sexes
This study is evaluating whether the addition of a drug to chemotherapy may help treat non-small cell lung cancer.
Phase-Based Estimates
1
Effectiveness
1
Safety
ARV-471
for Breast Cancer
Norwalk, CT
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Norwalk, CT
18+
All Sexes
This study is evaluating whether a combination of two drugs may help treat breast cancer.
Phase-Based Estimates
1
Effectiveness
2
Safety
Avelumab
for Carcinoma, Squamous Cell
Caldwell, ID
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Caldwell, ID
18+
All Sexes
This study is evaluating whether a combination of two immunotherapy drugs may help treat skin squamous cell cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
Selinexor
for Endometrial Neoplasms
Saginaw, MI
18+
Female
Phase 3
Waitlist Available
Locally Advanced
Saginaw, MI
18+
Female
This study is evaluating whether a drug may help prevent cancer from returning.
Phase-Based Estimates
2
Effectiveness
3
Safety
Laboratory Biomarker Analysis
for Breast Cancer
Niles, MI
18+
All Sexes
Phase 3
Recruiting
Metastatic
Niles, MI
18+
All Sexes
This study is evaluating whether a combination of chemotherapy drugs is more effective than chemotherapy alone in treating triple-negative breast cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
Glufosfamide
for Adenocarcinoma
Los Angeles, CA
18+
All Sexes
Phase 3
Recruiting
Metastatic
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a chemotherapy drug may help treat pancreatic cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
Salt And Baking Soda Rinse
for Esophagitis
Knoxville, TN
18+
All Sexes
Phase 3
Recruiting
Knoxville, TN
18+
All Sexes
As mentioned above, several prior studies have shown the positive effects of oral use of aloe vera juice in managing chemotherapy and radiation-induced oral mucositis and esophagitis. This study aims to add to the existing body of research around aloe vera juice and its effects on oral mucositis and esophagitis. The intention is to determine whether aloe vera juice should be considered as part of standard treatment.
Phase-Based Estimates
2
Effectiveness
3
Safety
Obicetrapib
for Atherosclerotic Cardiovascular Diseases
Fargo, ND
18+
All Sexes
Phase 3
Recruiting
Fargo, ND
18+
All Sexes
This study will be a placebo-controlled, double-blind, randomized, phase 3 study in participants with Atherosclerotic Cardiovascular Disease (ASCVD) who are not adequately controlled despite maximally tolerated lipid-lowering therapy.
Phase-Based Estimates
2
Effectiveness
3
Safety
Ziltivekimab
for Cardiovascular Diseases
Chapel Hill, NC
18+
All Sexes
Phase 3
Recruiting
Chapel Hill, NC
18+
All Sexes
This study is evaluating whether ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.
Phase-Based Estimates
2
Effectiveness
3
Safety
Tapinarof Cream, 1%
for Eczema, Infantile
Gresham, OR
Any Age
All Sexes
Phase 3
Recruiting
Gresham, OR
Any Age
All Sexes
This study is evaluating whether a cream can help treat atopic dermatitis.
Phase-Based Estimates
1
Effectiveness
2
Safety
Atezolizumab
for Carcinoma, Non-Small-Cell Lung
Baton Rouge, LA
18+
All Sexes
Phase 2
Recruiting
Locally Advanced
Baton Rouge, LA
18+
All Sexes
This study is evaluating whether a drug called NT-I7 can help treat lung cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
AZD9833
for Disease Progression
Hot Springs National Park, AR
18+
All Sexes
Phase 3
Recruiting
Locally Advanced
Hot Springs National Park, AR
18+
All Sexes
This study is evaluating whether a new drug can improve the effectiveness of a standard drug in treating breast cancer.
Phase-Based Estimates
1
Effectiveness
1
Safety
SARS-CoV-2 MRNA Vaccine Formulation 2
for COVID-19
Kansas City, MO
18+
All Sexes
Phase 1 & 2
Waitlist Available
Kansas City, MO
18+
All Sexes
The primary objectives of the study are: To describe the safety profile of all participants in each age group and each study intervention group up to 12 months post-last dose. To describe the neutralizing antibody profile at Day 1, Day 22, and Day 36 of each study intervention group. The secondary objectives of the study are: To describe binding antibody profile from Day 1 to Day 387 of each study intervention group. To describe the neutralizing antibody profile from Day 90 to Day 387 of each study intervention group. To describe the occurrence of virologically-confirmed COVID-19-like illness and serologically-confirmed SARS-CoV-2 infection. To evaluate the correlation/association between antibody responses to SARS-CoV-2 mRNA vaccine and the risk of virologically-confirmed COVID-19-like illness and/or serologically-confirmed SARS-CoV-2 infection.
Phase-Based Estimates
2
Effectiveness
3
Safety
Paclitaxel
for Ovary Cancer
Rochester, NY
18+
Female
Phase 3
Recruiting
Grade I
Rochester, NY
18+
Female
This study is evaluating whether a combination of two drugs may help treat ovarian cancer.
Phase-Based Estimates
1
Effectiveness
1
Safety
Percutaneous Coronary Intervention (PCI)
for Coronary Stenosis
Lebanon, NH
Any Age
All Sexes
Recruiting
Lebanon, NH
Any Age
All Sexes
This study is evaluating whether a strategy of complete revascularization involving staged PCI using third generation drug eluting stents to treat all suitable coronary artery lesions is superior to a strategy of medical therapy alone in reducing the composite outcome of Cardiovascular Death, new Myocardial Infarction, Ischemia
Phase-Based Estimates
2
Effectiveness
3
Safety
BGF MDI 320/28.8/9.6 Μg
for Asthma
Jackson Heights, NY
Any Age
All Sexes
Phase 3
Recruiting
Jackson Heights, NY
Any Age
All Sexes
This study is evaluating whether a new combination of medications may help treat severe asthma.
Phase-Based Estimates
1
Effectiveness
1
Safety
EsoGuard (lab Assay)
for Barrett Esophagus
Salt Lake City, UT
18+
Male
Recruiting
Salt Lake City, UT
18+
Male
This study is evaluating whether a combination of a new device and a lab developed test may help detect esophageal cancer.
Phase-Based Estimates
2
Effectiveness
3
Safety
Venetoclax
for Leukemia
Austin, TX
18+
All Sexes
Phase 3
Recruiting
Austin, TX
18+
All Sexes
This study is evaluating whether a combination of drugs may be more effective than other treatments for chronic lymphocytic leukemia.
Phase-Based Estimates
2
Effectiveness
3
Safety
BMS-986165
for Psoriasis
London, Canada
18+
All Sexes
Phase 3
Waitlist Available
London, Canada
18+
All Sexes
This study is evaluating whether a drug may help treat psoriasis.
Phase-Based Estimates
2
Effectiveness
3
Safety
Nab-paclitaxel
for Carcinoma, Squamous Cell
Hattiesburg, MS
18+
All Sexes
Phase 3
Waitlist Available
Locally Advanced
Hattiesburg, MS
18+
All Sexes
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, vs. pembrolizumab plus maintenance olaparib placebo for the treatment of squamous NSCLC. The study's 2 primary hypotheses are: Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to progression-free survival (PFS) per RECIST 1.1 by blinded independent clinical review (BICR). Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to overall survival (OS).
Phase-Based Estimates
2
Effectiveness
3
Safety
Baloxavir Marboxil
for Influenza, Human
Houston, TX
< 65
All Sexes
Phase 3
Recruiting
Houston, TX
< 65
All Sexes
This study is evaluating whether a medication may help treat influenza.
Phase-Based Estimates
1
Effectiveness
2
Safety
Questionnaire Administration
for Cancer of Oropharnyx
Mequon, WI
18+
All Sexes
Phase 2 & 3
Recruiting
Metastatic
Mequon, WI
18+
All Sexes
This study is evaluating whether a reduced dose of radiation therapy and nivolumab may be as effective as standard dose radiation therapy and cisplatin in treating patients with oropharynge
Phase-Based Estimates
2
Effectiveness
3
Safety
Etrasimod
for Colitis
Harrisburg, PA
Any Age
All Sexes
Phase 3
Recruiting
Harrisburg, PA
Any Age
All Sexes
This study is evaluating whether a drug may help treat ulcerative colitis.
Phase-Based Estimates
1
Effectiveness
2
Safety
Tyrosine Kinase Inhibitor
for Leukemia, Myeloid, Chronic-Phase
Chicago, IL
< 65
All Sexes
Phase 2
Recruiting
Chicago, IL
< 65
All Sexes
This study is evaluating whether stopping tyrosine kinase inhibitors will help patients with chronic myeloid leukemia in chronic phase continue or re-achieve molecular remission.
Phase-Based Estimates
2
Effectiveness
3
Safety
Ipilimumab
for Cancer
Richmond, VA