MitoQ for Sickle Cell Disease
(MitoQ Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease.The goal of this research is to study if MitoQ, a molecule that works as an antioxidant by removing potentially damaging agents in a living organism, improves platelet function in patients with sickle cell disease (SCD).
Will I have to stop taking my current medications?
The trial requires that you stop taking anti-platelet medications at least 4 weeks before joining. If you're on such medications, you'll need to stop them to participate.
How is the drug MitoQ different from other treatments for sickle cell disease?
MitoQ is unique because it is a mitochondria-targeted antioxidant, which means it specifically targets and protects the energy-producing parts of cells from damage. This approach is different from other treatments for sickle cell disease, which typically focus on managing symptoms or preventing complications rather than directly protecting cellular components.12345
Who Is on the Research Team?
Ramasubramanian Kalpatthi, MD
Principal Investigator
University of Pittsburgh
Are You a Good Fit for This Trial?
This trial is for African American adults over 18 with sickle cell anemia. Healthy African American adults can also participate as controls. People cannot join if they are pregnant, have known high blood pressure, use anti-platelet medication, had a transfusion within the last month, require hemodialysis or treatment for obstructive sleep apnea.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive oral MitoQ (20mg once a day) for 14 days to assess its effect on platelet function and vascular dysfunction in SCA patients
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of adverse events and changes in blood pressure and hemolytic markers
What Are the Treatments Tested in This Trial?
Interventions
- MitoQ
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pittsburgh
Lead Sponsor