Food Allergy Clinical Trials 2023

What Are Food Allergy Clinical Trials?

Food allergy is an adverse immune reaction to a particular food. Food-related allergies can trigger adverse symptoms like swelling, a constricted airway, hives, and digestive problems. In extreme cases, food allergies can cause anaphylaxis, a life-threatening reaction.

Food allergy can arise to any food. However, the most common food allergens – responsible for over 85% of food allergies – include eggs, milk, shellfish, fish, soy, peanut, tree nuts, sesame seeds, and wheat.

Researchers use clinical studies to identify allergen epitomes and to determine the efficacy and safety of treatment drugs and immunotherapies for food allergies. Clinical trials also help evaluate the compliance rate for emergency epinephrine – an emergency drug for severe allergic reactions and anaphylaxis.

Why Are Food Allergies Being Studied Through Clinical Trials?

In the United States, approximately 26 million adults and 5.6 million children have food allergies. Food allergies are a leading cause of anaphylaxis, causing over 200 deaths annually.

Accurate food allergy diagnosis and management are critical to prevent anaphylaxis and other food allergy-related symptoms.

Clinical trials allow scientists to discover why food allergies in the United States have dramatically increased in past years. Identifying the cause helps researchers find effective ways to treat and prevent food allergies. New treatment options can decrease the likelihood or severity of allergic reactions.

What Are The Types of Treatments Available For Food Allergies?

Abrocitinib 100mg for Food Allergy

This clinical study aims to assess the effectiveness and safety of abrocitinib, a targeted oral medication aimed to treat food allergy patients while avoiding injections.

Multi-OIT for Food Allergy

This clinical study aims to assess if low-dose immunotherapy can help treat children with multiple food allergies.

iREACH CDS Tool for Food Allergy Peanut

This clinical trial aims to assess the efficacy of an electronic health record-based tool. The iREACH intervention’s objective is to increase doctors’ PPA Guideline adherence and to decrease peanut allergy incidences by age 2.5.

What Are Some Recent Breakthrough Clinical Trials For Food Allergies?

2020: Palforzia is a groundbreaking peanut allergy treatment – In a Phase 3 clinical trial, 67% of patients were able to consume 600mg of Palforzia without severe symptoms. Palfozoria is the first FDA-approved treatment for peanut allergies in the United States.

2023: Single-cell technologies identified T-cell epitopes in food allergy – Scientists discovered T-cell epitopes in food allergies using single-cell technologies. These advancements open the door to new treatment developments for food allergies.

Who Are Some Of The Key Opinion Leaders / Researchers / Institutions Conducting Food Allergy Trial Research?

David Jeong, M.D., is board certified in Allergy & Immunology. Jeong is the principal investigator in numerous food allergy clinical trials. He also led a team of researchers studying T cells’ role in allergies.

Dr. Jeong currently works at the Institute for Asthma and Allergy, where he leads the Food Allergy Diagnosis, Research, & Treatment Center.

Robert Alan Wood, M.D., is Johns Hopkins Children’s Center’s chief of Allergy and Immunology. He is a food allergy expert with research interests in asthma, food allergy, peanut and milk allergies, allergens, and food hypersensitivity.

Dr. Wood has investigated over 20 research studies addressing the challenges of food allergies and asthma.