This trial is evaluating whether One-Step Open Feeding will improve 1 primary outcome and 1 secondary outcome in patients with Eczema, Infantile. Measurement will happen over the course of Oral Food Challenge Visits.
This trial requires 200 total participants across 4 different treatment groups
This trial involves 4 different treatments. One-Step Open Feeding is the primary treatment being studied. Participants will be divided into 4 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
The prevalence and incidence of eczema are underestimated because of the difficulty in ascertaining the diagnosis for patients with the condition. For example, if a parent reports that their child has eczema, a health care provider may be reluctant to make a formal diagnosis. While the prevalence of eczema is 0.2% in industrialized countries, it apparently ranges from about 0.5% to over 1% among the children of indigenous people of the Americas. If eczema was a disease of affluence and not a skin disease affecting some lower socioeconomic segments of the population, more than 2 million U.S. adults would be affected by it annually. The incidence of eczema is about 1 case per 1000 population.
Results from a recent clinical trial, topical or systemic antibiotics have not provided any advantage over control in this study. Moreover, some recent studies have shown that, in infants under 7 years of age, eczema is not a temporary condition. Therefore, a short term antibiotic treatment is not helpful in this condition.
Frequent use of topical corticosteroids and corticotherapies may be effective treatments for eczema, infantile, and may be particularly effective in the treatment of infants. The benefits of systemic corticosteroids are still controversial and not fully established; they are not routinely recommended. The optimal choice for patients with eczema, infantile, or atopic dermatitis, however, can be difficult and is often debated. The combination of short- to medium-term topical corticosteroids with systemic corticosteroids and/or nonsystemic corticosteroids may reduce the need for long-term systemic corticosteroids, reduce side effects, and reduce drug interaction problems.
Eczema, infantile affects at least half of the infants with recurrent respiratory infections and may be part of a complicated interplay involving multiple environmental factors. We found that the clinical impression of a parent was predictive of children with eczema, even after adjusting for multiple potential correlates. We suggest that the clinical impression of a parent may be one of the earliest clinical signs that may suggest the presence of eczema.
The cause of eczema, infantile is mainly due to a genetic component with environmental factors only very small. The use of antibiotics has to be regarded as an essential factor both in utero and early childhood which is in combination with a family background predisposing for eczema.
In spite of the improvement in care, there have still been few studies regarding one-step open feeding. Although the results of the aforementioned studies have been encouraging, the long-term benefits of one-step feeding still unknown. Nevertheless, there are still many clinicians who advocate for utilizing one-step open feeding therapy.
This article outlines several important information about eczema research. It introduces the concept of eczema subtyping (IgE-dependent and non-IgE-dependent) and discusses several clinical trials examining various types of eczema. Further, in the [Appendix], the authors provide evidence that eczema might be a good indication to test for familial predisposition to allergic diseases.
A 1-step open approach to infant feeding was effective in improving the quality of life across multiple areas of health, as well as reducing the amount of time taken to feed babies at the hospital.
Data from a recent study shows that open bottle can be implemented successfully by trained nurses, as long as adequate support is provided, irrespective of patient-to-patient variability.
Eczema is an inflammatory skin disease that commonly follows a pattern of skin irritations, which lead to the abnormal proliferation of the skin and underlying layer, namely the dermis. Dermatological research demonstrates the possibility of using the same anti-eczema target as a potential treatment strategy for other autoimmune conditions such as Crohn's disease. In addition, the most recent research showed that infantile eczema can be treated by oral and inhaled glucocorticosteroids that effectively reduce or remit disease flares and/or improve the patient-reported symptoms of this condition.
(1) One-step open feeding can be an effective treatment of infantile eczema for infants aged 3–5 months. (2) The time-to-nonsnoring interval is shorter when the infant is open fed. (3) We propose that two-step open feeding should be the first choice of treatment for infants with infantile eczema.