Study Summary
This trial will test whether a targeted brain stimulation called HD-tDCS can help reduce muscle synergy impairment, which is a major limitation to the recovery of independent function after a stroke.
Treatment Effectiveness
Study Objectives
1 Primary · 1 Secondary · Reporting Duration: Baseline (initial visit), before (within 30 min range) and immediately after (within 30 mins range) the intervention
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
3 Treatment Groups
Cathodal stimulation
1 of 3
Sham stimulation
1 of 3
Anodal stimulation
1 of 3
Experimental Treatment
12 Total Participants · 3 Treatment Groups
Primary Treatment: Transcranial direct current stimulation (high-definition) · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 90 · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| Texas | 100.0% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| University of Oklahoma Health Sciences Center | 100.0% |
What portion of applicants met pre-screening criteria?
| Met criteria | 100.0% |
- Williamson J, James SA, Apple B, Sharps J, Sidorov E.V., Yang Y, (2022), High Definition Transcranial Direct Current Stimulation for Improving Upper Extremity Motor Function post Stroke. June 8-10, the 3rd International Workshop on Non-Invasive Brain Stimulation (NIBS) 2022.
- Lepak L.V., Cheema C.F, James S.A., Yang Y (2023), Computer-Guided Non-Invasive High-Definition Transcranial Direct Current Brain Stimulation as a Targeted Intervention after a Stroke, American Physical Therapy Association (APTA) Combined Sections Meeting (CSM), San Diego, CA, Feb 23-25, 2023
- 2022. "Targeted High-definition Transcranial Direct Current Stimulation (HD-tDCS) for Reducing Post-stroke Movement Impairments". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05174949.
Frequently Asked Questions
Does this research have an age cutoff for participants?
"This clinical trial is only open to patients between 18 and 90 years old. Alternatively, there are 38 trials for individuals below the age of majority and 1006 studies available for those over 65." - Anonymous Online Contributor
Do I meet the criteria to partake in this medical experiment?
"This experiment requires 12 individuals who have suffered a stroke, aged 18 to 90. Most importantly, they must possess paresis limited to one side of their body and moderate-severe motor impairment in their upper extremity (Fugl-Meyer score between 10 - 40)." - Anonymous Online Contributor
How many participants are being allowed to partake in this clinical exploration?
"Yes, per the information on clinicaltrials.gov, this medical trial is presently enrolling participants. It was initially brought to attention in January 18th 2022 and has been modified as of October 31st 2022. The study requires 12 volunteers from a single site for completion." - Anonymous Online Contributor
Are there still vacancies in this research endeavor?
"Affirmative. Clinicaltrials.gov provides evidence that this medical experiment is actively looking for volunteers, which was first posted on January 18th 2022 and last edited in October 31st 2022. This study requires 12 participants from one clinical site." - Anonymous Online Contributor