Perineural Steroid Injections Plus Radiofrequency Ablation for Osteoarthritis, Hip

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Texas Southwestern Medical Center, Dallas, TX
Osteoarthritis, Hip+2 More
Perineural Steroid Injection - Procedure
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

The purpose of this trial is to determine if radiofrequency ablation plus steroid perineural injections at the knee or hip provide longer pain relief and better function to patients than the current standard of care, perineural steroid injections alone. This pilot study is a prospective two arm randomized trail, all participants will be recruited from the University of Texas Southwestern Medical Center (UTSW) outpatient orthopedic clinic. 40 participants (20 hip and 20 knee OA) will be enrolled into the standard of care arm (treated with steroid injections alone) and 40 participants (20 hip and 20 knee OA) will be enrolled into the investigational arm (treatment with a combination of radiofrequency ablation (RFA) plus steroid injections) for a total of 80 enrolled participants. All subjects will complete a function and pain assessment at the time of injection and three additional time points: 2 weeks, 3 months, and 6 months post injection. This study will use the same knee function questionnaire and frequency currently used in clinic per standard of care. In addition, all participant's surgical history and prior injection history will be reviewed via the Electronic Medical Record (EMR).

Eligible Conditions

  • Osteoarthritis, Hip
  • Osteoarthritis, Knee

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Osteoarthritis, Hip

Study Objectives

8 Primary · 0 Secondary · Reporting Duration: 6 months post procedure

2 weeks post procedure
Hip Functional score at 2 weeks post procedure
Knee Functional score as measured by standard of care questionnaire for knee OA at 2 weeks post procedure
3 months post procedure
Hip Functional score at 3 months post procedure
Knee Functional score as measured by standard of care questionnaire for knee OA at 3 months post procedure
6 months post procedure
Hip Functional score at 6 months post procedure
Knee Functional score as measured by standard of care questionnaire for knee OA at 6 months post procedure
Baseline (Pre-Procedure)
Hip Functional score at baseline (pre-procedure)
Baseline (pre-procedure)
Knee Functional score as measured by standard of care questionnaire for knee OA at baseline (pre-procedure)

Trial Safety

Safety Progress

1 of 3

Other trials for Osteoarthritis, Hip

Trial Design

2 Treatment Groups

Perineural Steroid Injections Alone
1 of 2
Perineural Steroid Injections Plus Radiofrequency Ablation
1 of 2
Active Control
Experimental Treatment

80 Total Participants · 2 Treatment Groups

Primary Treatment: Perineural Steroid Injections Plus Radiofrequency Ablation · No Placebo Group · N/A

Perineural Steroid Injections Plus Radiofrequency AblationExperimental Group · 2 Interventions: Perineural Steroid Injection, Radiofrequency Ablation (RFA) · Intervention Types: Procedure, Procedure
Perineural Steroid Injections Alone
Procedure
ActiveComparator Group · 1 Intervention: Perineural Steroid Injection · Intervention Types: Procedure
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Radiofrequency Ablation (RFA)
2016
N/A
~70

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 months post procedure

Trial Background

Avneesh Chhabra, Chief, Musculoskeletal Radiology
Principal Investigator
University of Texas Southwestern Medical Center
Closest Location: University of Texas Southwestern Medical Center · Dallas, TX
Photo of university of texas southwestern medical center  1Photo of university of texas southwestern medical center  2Photo of university of texas southwestern medical center  3
2008First Recorded Clinical Trial
1 TrialsResearching Osteoarthritis, Hip
429 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have osteoarthritis of the knee or hip.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References