PNS Therapy vs. Steroid Injections for Chronic Knee Pain
Trial Summary
What is the purpose of this trial?
To compare the effects of the following types of therapy on knee range of motion when given to patients with chronic knee pain: * A standard steroid injection * Peripheral nerve stimulation (PNS) therapy in combination with a standard steroid injection * PNS therapy in combination with a placebo injection Steroid injections are given directly into the knee joints and are considered to be the standard therapy for chronic knee pain. In this study, the injection will be made of the steroid drugs triamcinolone and bupivacaine.
Do I need to stop my current medications for the trial?
The trial information does not specify if you need to stop taking your current medications. However, if you are on opioids for reasons other than knee pain, you cannot participate in the trial.
What data supports the effectiveness of the treatment for chronic knee pain?
Is triamcinolone safe for use in humans?
How does the treatment of Bupivacaine and Triamcinolone for chronic knee pain differ from other treatments?
This treatment combines Bupivacaine, a local anesthetic that numbs the area, with Triamcinolone, a steroid that reduces inflammation, offering both immediate pain relief and longer-term anti-inflammatory effects. This dual-action approach is unique compared to treatments that use only one type of medication.137910
Research Team
Saba Javed, M D
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for adults aged 18-85 with chronic knee pain, treated at the MD Anderson Cancer Center. Eligible participants must have a baseline pain score of 4 or higher and be able to consent. Those with opioid use unrelated to knee pain, cognitive issues, skin infections, recent substance abuse history, or allergies to local anesthetics or steroids cannot join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either a standard steroid injection, PNS therapy plus a standard steroid injection, or PNS therapy plus a placebo injection
Follow-up
Participants are monitored for changes in knee range of motion and pain scores at 30, 60, and 90 days from baseline
Treatment Details
Interventions
- Bupivacaine
- Peripheral Nerve Stimulation
- Placebo
- Triamcinolone
Bupivacaine is already approved in United States, European Union, Canada for the following indications:
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor