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Corticosteroid

PNS Therapy vs. Steroid Injections for Chronic Knee Pain

N/A

Recruiting

Led By Saba Javed, MD

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion; an average of 1 year

Awards & highlights

Study Summary

This trial will compare the effects of steroid injections, PNS therapy with a steroid injection, and PNS therapy with a placebo injection on knee range of motion in patients with chronic knee pain.

Who is the study for?

This trial is for adults aged 18-85 with chronic knee pain, treated at the MD Anderson Cancer Center. Eligible participants must have a baseline pain score of 4 or higher and be able to consent. Those with opioid use unrelated to knee pain, cognitive issues, skin infections, recent substance abuse history, or allergies to local anesthetics or steroids cannot join.Check my eligibility

What is being tested?

The study compares three treatments: a standard steroid injection into the knee; peripheral nerve stimulation (PNS) plus steroid injection; and PNS with a placebo. The goal is to see which method best improves knee movement in patients suffering from chronic knee pain.See study design

What are the potential side effects?

Possible side effects include reactions at the injection site such as pain or infection for both steroid and placebo injections. PNS therapy might cause discomfort where the device attaches or temporary changes in skin sensation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion; an average of 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion; an average of 1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion; an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 4.0

Trial Design

3Treatment groups

Experimental Treatment

Group I: Group 3 (PNS therapy plus 1 placebo injection)Experimental Treatment2 Interventions

Participants will receive PNS therapy plus 1 placebo injection.

Group II: Group 2 (PNS therapy plus 1 standard steroid injection).Experimental Treatment3 Interventions

Participants will receive PNS therapy plus 1 standard steroid injection.

Group III: Group 1 (standard steroid injection)Experimental Treatment2 Interventions

Participants will receive 1 standard steroid injection.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Triamcinolone

2016

Completed Phase 4

~1220

Bupivacaine

2013

Completed Phase 4

~1530

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor

2,974 Previous Clinical Trials

1,789,351 Total Patients Enrolled

Saba Javed, MDPrincipal InvestigatorM.D. Anderson Cancer Center

1 Previous Clinical Trials

10 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many volunteers are participating in this trial overall?

"Affirmative. According to information found on clinicaltrials.gov, this experimental trial is currently enrolling participants; initial posting occured on August 10th 2023 and the most recent update was published on August 15th 2023. The study requires 45 volunteers from one medical centre."

Answered by AI

Is this research endeavor actively seeking participants?

"Correct. Clinicaltrials.gov attests that this clinical trial, initially posted on August 10th 2023, is currently in search of 45 patients at one site. The listing was recently updated on the 15th of August 2023."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

2023. "Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06004882.

All > Knee Pain