This trial is evaluating whether Venlafaxine 37.5 MG will improve 1 primary outcome and 7 secondary outcomes in patients with Acute Pain. Measurement will happen over the course of 7 days.
This trial requires 100 total participants across 2 different treatment groups
This trial involves 2 different treatments. Venlafaxine 37.5 MG is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.
"Current research is only beginning to shed light on the neural bases for these discrepancies, and the role of genetics as a contributing force is currently being researched intensively. Research is needed to increase our understanding of the interaction between the genetics and pain processing mechanisms associated with the development of chronic pain." - Anonymous Online Contributor
"Common treatments for chronic pain include analgesics and prescription opioids, and other nonprescription analgesics (nonopioids). Most patients with chronic pain have some form of pain management problems and may not be interested in alternative treatments." - Anonymous Online Contributor
"The most common symptom of [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) is pain, while in many cases, non-pain symptoms predominate. Non-pain symptoms are most often debilitating. Symptoms of psychosocial distress, including somatic complaints, anxiety or depressive reactions, hypersensitivity, poor coping skills and high levels of pain catastrophizing often predominate. In chronic pain, these non-pain symptoms are more disabling than pain alone. Chronic pain may also cause problems in social and work capacities. It is advisable to consider pain in all chronic pain patients in which there are no specific causes to look for elsewhere or not." - Anonymous Online Contributor
"Chronic pain is a global problem defined by a strong desire to relieve or avoid pain. Pain can be attributed to medical conditions, psychological processes, or multiple causes. Clinicians should screen patients for chronic post-traumatic pain and identify the specific causes of chronic pain." - Anonymous Online Contributor
"Of those who did not obtain treatment, nearly half had some degree of chronic pain with disabling symptoms. This prevalence of chronic pain is similar to that reported in other population studies." - Anonymous Online Contributor
"Chronic pain cannot be cured. However, most patients can reduce the intensity and distress they feel if they are properly treated. Those who have chronic pain may be able to lead an independent, productive and self-sufficiency life." - Anonymous Online Contributor
"Venlafaxine 37.5 mg improved self-rated health, but other measures of QoL were not changed. This is in line with previously published data, suggesting that the majority of clients continue to use opioids and benzodiazepines to manage their chronic pain." - Anonymous Online Contributor
"There hasn’t yet been any breakthrough in the treatment of [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain). However we are moving into a new day when a large body of evidence has emerged on the biologic and pharmacologic basis of chronic pain. This evidence has led to increased understanding of basic biology processes that influence pain and our understanding for potential mechanisms that can affect the pain perception and affect the underlying mechanisms that regulate the pain signaling. The majority of chronic pain is now believed to be mediated through a complex system of peripheral, spinal, and central nervous system plasticity that is modulated at both peripheral and central level. This system can be modified through a variety of mechanisms, both physiologic and pharmacologic." - Anonymous Online Contributor
"There has not been enough evidence to show that venlafaxine is not effective for the treatment of chronic pain, which makes the results of our study inconclusive." - Anonymous Online Contributor
"Venlafaxine 37.5-mg tablets are well tolerated, produce an adequate therapeutic response for moderate to severe pain relief, and may be effective for short term and sustained reduction in pain in some patients. However, given the limited sample size of this study and the lack of data on its duration, these data cannot be regarded as being reliable. As such the results should not be used as a basis for prescribing venlafaxine 37.5 mg tablets to patients needing long-term therapeutic treatment or for assessing the efficacy of this agent in the management of chronic pain. Venlafaxine 37." - Anonymous Online Contributor
"In a recent study, findings of this study have confirmed that the antidepressant venlafaxine 37.5 mg is effective in the treatment of major depressive episodes." - Anonymous Online Contributor