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Serotonin-Norepinephrine Reuptake Inhibitor

Venlafaxine 37.5 MG for Chronic Pain

Phase 4
Recruiting
Led By Matthias Behrends, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult (male and female) subjects aged 18 to 75
Scheduled for primary total knee arthroplasty with planned spinal anesthesia with saphenous peripheral nerve block at the adductor canal
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

This trial is investigating whether Venlafaxine can help manage pain better than opioids after knee surgery, as well as reducing the risk of chronic pain.

Who is the study for?
This trial is for English-speaking adults aged 18 to 75 who are scheduled for primary total knee replacement surgery with specific anesthesia. It's not for those on antidepressants, triptans, or linezolid; with allergies to study meds; BMI over 40; prior knee surgery; recent falls; liver/renal failure; bleeding disorders; general anesthesia use; diabetic nerve pain history or chronic opioid/benzodiazepine users.Check my eligibility
What is being tested?
The trial tests if Venlafaxine (37.5 MG) can reduce pain and opioid use after knee replacement compared to a placebo. The focus is on the first day post-op and one week later, plus checking if it lowers long-term chronic pain at three months.See study design
What are the potential side effects?
Venlafaxine may cause side effects like nausea, vomiting, dizziness, dry mouth, sleepiness or insomnia. Unlike opioids, it's less likely to cause respiratory issues but could affect mood and cognitive functions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 75 years old.
Select...
I am scheduled for a knee replacement surgery with specific anesthesia and nerve block.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cumulative 24 hour total opioid consumption
Secondary outcome measures
Functionality at 3 months postoperatively
Functionality at 7 days postoperatively
Opioid consumption at 3 months postoperatively
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: VenlafaxineExperimental Treatment1 Intervention
Subjects in venlafaxine arm will receive venlafaxine 37.5mg daily for 7 consecutive days starting on day of primary arthroplasty surgery.
Group II: PlaceboPlacebo Group1 Intervention
Subjects in placebo arm will receive inactive placebo capsule daily for 7 consecutive days starting on day of primary arthroplasty surgery.

Find a Location

Who is running the clinical trial?

Orthopedic Research and Education FoundationOTHER
19 Previous Clinical Trials
11,300 Total Patients Enrolled
University of California, San FranciscoLead Sponsor
2,505 Previous Clinical Trials
15,237,455 Total Patients Enrolled
13 Trials studying Chronic Pain
1,701 Patients Enrolled for Chronic Pain
Matthias Behrends, MDPrincipal InvestigatorUniversity of California, San Francisco
2 Previous Clinical Trials
200 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What common ailments is Venlafaxine 37.5 MG prescribed to treat?

"Venlafaxine 37.5 MG is frequently prescribed for social phobia, as well as prophylaxis of migraine headaches and managing neuropathic pain."

Answered by AI

Are there any documented cases of Venlafaxine 37.5 MG being tested experimentally?

"Presently, 10 clinical trials are researching the effects of Venlafaxine 37.5 MG with 4 in their final stage. These studies span 23 sites across America, a vast majority based out of Charleston, South carolina."

Answered by AI

Is this experiment an unprecedented attempt to address the issue?

"At present, 10 studies for Venlafaxine 37.5 MG are being conducted across 19 cities and two countries. Jiangsu Hansoh Pharmaceutical Co., Ltd.'s 2013 study was the earliest of its kind and completed Phase 2 & 3 drug approval with 300 participants. Since then, a total of 18414 trials have been undertaken."

Answered by AI

How many participants are eligible for inclusion in this clinical research?

"Affirmative. According to clinicaltrials.gov, this research endeavour is currently recruiting individuals and was initially published on May 10th 2021 with the most recent changes taking place July 5th 2022. One hundred volunteers must be recruited from a solitary medical facility for participation in this study."

Answered by AI

To what extent can Venlafaxine 37.5 MG endanger individuals?

"Due to its Phase 4 status, which indicates the approval of this particular treatment, Venlafaxine 37.5 MG's safety has been rated a 3 on our scale at Power."

Answered by AI

Are there available slots for potential participants of this experiment?

"Clinicaltrials.gov indicates that this trial is currently accepting patients. It was initially advertised on the 10th of May 2021, and underwent its last edit on 5 July 2022."

Answered by AI

Are participants below the age of 40 eligible for this clinical study?

"This medical trial only accepts patients over the age of majority and younger than 75 years old."

Answered by AI

Am I eligible to be a subject in this research endeavor?

"This scientific investigation calls for 100 adults (male and female) aged between 18 to 75 with acute pain. It is essential that potential participants meet these specific requirements."

Answered by AI

Who else is applying?

What state do they live in?
Nevada
California
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
3+
What site did they apply to?
University of California San Francisco

Why did patients apply to this trial?

pain releif money for trial. loking to be apart of a better solution to make a difference for someome who is in need.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
2021. "The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05023278.
All > Acute Pain > Effexor
~19 spots leftby Dec 2024
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