Venlafaxine 37.5 MG for Acute Pain

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
University of California San Francisco, San Francisco, CA
Acute Pain+4 More
Venlafaxine 37.5 MG - Drug
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a medication called venlafaxine can reduce pain and opioid use after knee replacement surgery.

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Eligible Conditions

  • Acute Pain
  • Neuropathic Pain
  • Knee Pain Chronic
  • Chronic Pain

Treatment Effectiveness

Effectiveness Estimate

3 of 3
This is better than 93% of similar trials

Study Objectives

This trial is evaluating whether Venlafaxine 37.5 MG will improve 1 primary outcome and 7 secondary outcomes in patients with Acute Pain. Measurement will happen over the course of 7 days.

24 hours
Cumulative 24 hour total opioid consumption
Pain numeric rating scale at 24 hours post operatively
3 months
Functionality at 3 months postoperatively
Opioid consumption at 3 months postoperatively
Pain severity and interference at 3 months post operatively
7 days
Functionality at 7 days postoperatively
Opioid consumption at 7 days postoperatively
Pain severity and interference at 7 days post operatively

Trial Safety

Safety Estimate

3 of 3
This is better than 85% of similar trials

Trial Design

2 Treatment Groups

Venlafaxine
1 of 2
Placebo
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 100 total participants across 2 different treatment groups

This trial involves 2 different treatments. Venlafaxine 37.5 MG is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.

Venlafaxine
Drug
Subjects in venlafaxine arm will receive venlafaxine 37.5mg daily for 7 consecutive days starting on day of primary arthroplasty surgery.
Placebo
Drug
Subjects in placebo arm will receive inactive placebo capsule daily for 7 consecutive days starting on day of primary arthroplasty surgery.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 3 months for reporting.

Closest Location

University of California San Francisco - San Francisco, CA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
They are scheduled for a primary total knee replacement surgery that will be done under spinal anesthesia show original
From 18 to 75 years old, both male and female adults are included. show original
English speaking

Patient Q&A Section

What causes chronic pain?

"Current research is only beginning to shed light on the neural bases for these discrepancies, and the role of genetics as a contributing force is currently being researched intensively. Research is needed to increase our understanding of the interaction between the genetics and pain processing mechanisms associated with the development of chronic pain." - Anonymous Online Contributor

Unverified Answer

What are common treatments for chronic pain?

"Common treatments for chronic pain include analgesics and prescription opioids, and other nonprescription analgesics (nonopioids). Most patients with chronic pain have some form of pain management problems and may not be interested in alternative treatments." - Anonymous Online Contributor

Unverified Answer

What are the signs of chronic pain?

"The most common symptom of [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) is pain, while in many cases, non-pain symptoms predominate. Non-pain symptoms are most often debilitating. Symptoms of psychosocial distress, including somatic complaints, anxiety or depressive reactions, hypersensitivity, poor coping skills and high levels of pain catastrophizing often predominate. In chronic pain, these non-pain symptoms are more disabling than pain alone. Chronic pain may also cause problems in social and work capacities. It is advisable to consider pain in all chronic pain patients in which there are no specific causes to look for elsewhere or not." - Anonymous Online Contributor

Unverified Answer

What is chronic pain?

"Chronic pain is a global problem defined by a strong desire to relieve or avoid pain. Pain can be attributed to medical conditions, psychological processes, or multiple causes. Clinicians should screen patients for chronic post-traumatic pain and identify the specific causes of chronic pain." - Anonymous Online Contributor

Unverified Answer

How many people get chronic pain a year in the United States?

"Of those who did not obtain treatment, nearly half had some degree of chronic pain with disabling symptoms. This prevalence of chronic pain is similar to that reported in other population studies." - Anonymous Online Contributor

Unverified Answer

Can chronic pain be cured?

"Chronic pain cannot be cured. However, most patients can reduce the intensity and distress they feel if they are properly treated. Those who have chronic pain may be able to lead an independent, productive and self-sufficiency life." - Anonymous Online Contributor

Unverified Answer

Does venlafaxine 37.5 mg improve quality of life for those with chronic pain?

"Venlafaxine 37.5 mg improved self-rated health, but other measures of QoL were not changed. This is in line with previously published data, suggesting that the majority of clients continue to use opioids and benzodiazepines to manage their chronic pain." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating chronic pain?

"There hasn’t yet been any breakthrough in the treatment of [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain). However we are moving into a new day when a large body of evidence has emerged on the biologic and pharmacologic basis of chronic pain. This evidence has led to increased understanding of basic biology processes that influence pain and our understanding for potential mechanisms that can affect the pain perception and affect the underlying mechanisms that regulate the pain signaling. The majority of chronic pain is now believed to be mediated through a complex system of peripheral, spinal, and central nervous system plasticity that is modulated at both peripheral and central level. This system can be modified through a variety of mechanisms, both physiologic and pharmacologic." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving venlafaxine 37.5 mg?

"There has not been enough evidence to show that venlafaxine is not effective for the treatment of chronic pain, which makes the results of our study inconclusive." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in venlafaxine 37.5 mg for therapeutic use?

"Venlafaxine 37.5-mg tablets are well tolerated, produce an adequate therapeutic response for moderate to severe pain relief, and may be effective for short term and sustained reduction in pain in some patients. However, given the limited sample size of this study and the lack of data on its duration, these data cannot be regarded as being reliable. As such the results should not be used as a basis for prescribing venlafaxine 37.5 mg tablets to patients needing long-term therapeutic treatment or for assessing the efficacy of this agent in the management of chronic pain. Venlafaxine 37." - Anonymous Online Contributor

Unverified Answer

Has venlafaxine 37.5 mg proven to be more effective than a placebo?

"In a recent study, findings of this study have confirmed that the antidepressant venlafaxine 37.5 mg is effective in the treatment of major depressive episodes." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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