Treatment for Optic Neuritis

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Iowa, Iowa City, IA
Optic Neuritis+2 More
Eligibility
18 - 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether corticosteroid treatment for optic neuritis is safe and effective.

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Eligible Conditions

  • Optic Neuritis
  • Multiple Sclerosis

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Optic Neuritis

Trial Safety

Safety Progress

1 of 3

Other trials for Optic Neuritis

Trial Design

0 Treatment Group

This trial involves 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 5 years for reporting.

Closest Location

University of Iowa - Iowa City, IA

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
A relative afferent pupillary defect and a visual field defect in the affected eye
No previous corticosteroid treatment for optic neuritis or multiple sclerosis
No previous episodes of optic neuritis in the affected eye
Age range of 18 to 46 years
Acute unilateral optic neuritis with visual symptoms for 8 days or less
No systemic disease other than multiple sclerosis that might be the cause of the optic neuriti

Patient Q&A Section

What is optic neuritis?

"Although only 5% of patients will develop optic neuritis, it can be severe and irreversible. It results in temporary loss of visual function. Its cause is unknown but it is more common in females than in men and in European than in Asian populations. It has a high fatality rate. Optic neuritis represents a disease process that can occur at any age but most commonly takes place in children and young adults. It may cause permanent neurological dysfunction. Nucleoside triphosphates (i.e. cellular energy) are important to nerve function and are found in all cellular nuclei. In optic neuritis the function of nerve cells in the brain is damaged. Neurofilament subunits are the structural basis for nerve fibre fibers." - Anonymous Online Contributor

Unverified Answer

How many people get optic neuritis a year in the United States?

"Each year, approximately 3% of American adults (about 3.5 million) are diagnosed with some form of optic neuritis. In one year, about 25% of all American adults will experience some form of new-onset visual loss." - Anonymous Online Contributor

Unverified Answer

What causes optic neuritis?

"Although the exact cause of optic neuritis is not yet completely understood, the most common causes are infections, autoimmune diseases and nutritional deficiencies. The disease can be associated with vitamin B, and chronic alcoholism may exacerbate it." - Anonymous Online Contributor

Unverified Answer

What are the signs of optic neuritis?

"Some of the symptoms of optic neuritis may include sudden onset to painful progressive loss of vision (nystagmus, photophobia, floaters, light sensitivity, visual acuity, color loss, amaurosis fugax and photopsia), bilateral visual loss (amaurotis/amaurosis fugax) and unilateral visual loss (hemianopsia, photopsia, tunnel vision, monocular tunnel vision). \n\nOptic neuritis is an inflammatory condition of the optic nerve that manifests as vision loss (often temporary) in one or both eyes. It can affect both eyes or only one eye. Often, both eyes are not affected and the person has no sensory symptoms. Symptoms can be gradual." - Anonymous Online Contributor

Unverified Answer

Can optic neuritis be cured?

"Findings from a recent study is a retrospective review in which subjects were treated based solely on clinical findings and patient-reported outcomes. Additional studies, including randomized controlled trials of therapeutic modalities used to treat optic neuritis, are needed to confirm our findings." - Anonymous Online Contributor

Unverified Answer

What are common treatments for optic neuritis?

"It appears that corticosteroids are probably the first-line treatment for most instances of acute optic neuritis, though some recent studies suggest that their use appears less necessary in the more acute types. Other drugs frequently used (e.g. immunosuppressants, acetylcholinesterase inhibitors, etc.) tend to be either inappropriate or ineffective for optic neuritis, although their possible use should be further verified in some cases. Generally, an ophthalmologist or optometrist is the doctor who should be consulted due to the importance of early diagnosis and treatment." - Anonymous Online Contributor

Unverified Answer

Does treatment improve quality of life for those with optic neuritis?

"A small but statistically significant increase in QoL was observed in those receiving medication, but this did not translate into a clinically meaningful improvement in the patients' global QRS. Findings from a recent study was not powered to detect a clinically meaningful difference based on the clinical presentation in this group." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"[Optic neuritis must be treated aggressively with a combination of corticosteroids and antiviral medication and/or a combination of corticosteroids, penicilins, and antiviral medication, all injected inside the eye's optic disc, if at all possible.] There is still not enough research on the best way to inject the medications inside the eye. The best way to understand how to administer the medications is through clinical trials, where doctors, or researchers study medicines on patients to find the best way to make the drugs more or less safe and effective. [Power] can help guide patients toward the best trial for them." - Anonymous Online Contributor

Unverified Answer

Does optic neuritis run in families?

"We have identified an additional family with optic neuritis that carries a mutation in optineurin, and this may be a useful addition to the genotypic markers already listed as predisposing genetic factors." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of optic neuritis?

"The main cause of ON was a bacterial infection and the primary pathogens were Enterococcus faecalis and Streptococcus pyogenes. The main cause of retrobulbar neuritis was an aseptic meningitis." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in treatment for therapeutic use?

"[Treatments for optic neuropathy(s) or optic neuritis have become advanced. For the former a steroid is now the therapy of choice for optic neuropathy in most countries where this has become available. Steroid sparing regimes have also become common for optic neuropathy. Optic neuritis is often a self-resolving condition now but can respond to treatments in time. A recent review of therapeutic regimens is available.]<br>\nTherapeutic approaches with potential or proven efficacy in the treatment of optic neuritis may include:\n\n- Anti-bacterial treatment as the primary treatment is used." - Anonymous Online Contributor

Unverified Answer

Is treatment safe for people?

"We found that a significant proportion of patients with ON had a history of [allergy](https://www.withpower.com/clinical-trials/allergy). It is not always practical to exclude people such as this from treatment. We did not assess the severity of ON and do not consider it crucial to exclude patients with mild or early ON. Findings from a recent study support further studies to assess the prevalence of other, as yet unrecognised allergies in patients with ON." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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