CogMed for Drug Abuse

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
NY State Psychiatric Institute, New York, NY
Drug Abuse+4 More
CogMed - Other
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a computerized working memory training program can improve cognitive functioning in people who have used opioids.

See full description

Eligible Conditions

  • Drug Abuse
  • Opioids Use
  • Opioid Use Disorder (OUD)
  • Cognitive Changes

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Drug Abuse

Study Objectives

This trial is evaluating whether CogMed will improve 1 primary outcome and 4 secondary outcomes in patients with Drug Abuse. Measurement will happen over the course of 3-month Follow up.

3-month Follow up
NIH Toolbox Cognition Battery
3-month follow up
Illicit Substance Use: Timeline Follow Back (TLFB)
Impulsive decision making (Delay Discounting Task)
Psychosocial Functioning (Brief Inventory of Psychosocial Functioning B-IPF)
Quality of Life Scale (QOLS)

Trial Safety

Safety Progress

1 of 3

Other trials for Drug Abuse

Trial Design

2 Treatment Groups

Sham
1 of 2
Active
1 of 2
Active Control
Experimental Treatment

This trial requires 36 total participants across 2 different treatment groups

This trial involves 2 different treatments. CogMed is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Active
Other
Working memory training with task-difficulty increasing across sessions
Sham
Other
Working memory training with task-difficulty remaining constant across sessions.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3-month follow up
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 3-month follow up for reporting.

Who is running the study

Principal Investigator
S. D. C.
Prof. Sandra D. Comer, Professor of Neurobiology
New York State Psychiatric Institute

Closest Location

NY State Psychiatric Institute - New York, NY

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Drug Abuse or one of the other 4 conditions listed above. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Meets DSM-5 criteria for moderate-severe Opioid Use Disorder (OUD) in the past 6 months
In good physical health
Enrolled in a suboxone (buprenorphine/naloxone) program; willing to provide consent for research team to contact treatment provider
Recent history of illicit opioid use
History of at least 1 prior opioid overdose
Access to a smartphone, tablet, or computer

Patient Q&A Section

What causes opioid abuse?

"Opioid abuse is caused by a number of factors, some of which are external and others internal, including family, peer, and personal influences and attitudes. Effective treatment of opioid addicts requires addressing all the underlying risk factors." - Anonymous Online Contributor

Unverified Answer

How many people get opioid abuse a year in the United States?

"Approximately 0.5 million people are currently identified as opioid abusers each year. Findings from a recent study may help identify the magnitude of the current epidemic in America and other countries." - Anonymous Online Contributor

Unverified Answer

Can opioid abuse be cured?

"Opioid abuse cannot be cured in the short term. However, if the disease resolves itself, abstinence from drugs is a cure for both symptom control and to reduce the risk of developing a new opioid-associated condition or the worsening of an existing one." - Anonymous Online Contributor

Unverified Answer

What is opioid abuse?

"In the present study, patients receiving an opioid maintenance treatment exhibited high rates of substance abuse. However, the study design does not allow inference what drug abuse level is a reflection of opioid maintenance therapies in general. In addition, the number of opioid use disorders was low. In this regard, our findings are in contrast to many previous studies, that heroin is an important illicit substance." - Anonymous Online Contributor

Unverified Answer

What are the signs of opioid abuse?

"The signs of opioid abuse include increased weight (in the absence of caloric deficit from dieting, loss of muscle mass in the absence of a negative energy balance due to poor protein intake), abdominal or hip swelling, decreased appetite or overeating, or persistent depression or dysphoria despite opioid use being reduced.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for opioid abuse?

"The vast majority of people with chronic opioid use, although addicted to opioids, do not seek treatment for opioid abuse. Those who do seek help want to change habits, including cessation of use. Most want medical advice from trained addiction specialists. They also want pharmacological treatment. Most feel that the public needs information and education about opioid problems and about the available treatment options." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving cogmed?

"The NDA for "Cogmed" is currently held by the U.S. Food and Drug Administration. answer: There have been several clinical trials evaluating the potential of Cogmed in the treatment of chronic pain with moderate to high scientific validity. Clinical trials that have not been finalized have the label "No firm conclusions are available." The purpose of this article is to provide the scientific reader with a complete picture of the current clinical trial status and progress, as well as to describe the current investigational product: Cogmed (NCT01252990)." - Anonymous Online Contributor

Unverified Answer

Has cogmed proven to be more effective than a placebo?

"The study concluded Cogmed Pro had been shown to be more effective than a placebo. The study also stated that Cogmed Pro should have been considered as a therapeutic method in patients with severe or chronic cases of addiction." - Anonymous Online Contributor

Unverified Answer

What is the latest research for opioid abuse?

"The most recent, most effective treatment program is the opioid treatment approach-based on the concept that addiction can be effectively treated with opioid replacement therapy. Opioid treatment programs are available for treatment in [rehabilitation] and [specialized clinics] in the United States. However, research needs to be done to support this approach in other locations, such as the UK and Canada, as well as to increase the size of the clinical trial populations and the intensity of the program. The US addiction treatment community must join with the addiction research community to expand the program of opioid treatment and research. Please visit www.uuhm.org to learn more about opioid treatment and treatment." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of cogmed?

"There is a wide range of common side effects from use of cogmed. Some of the side effects include nausea, sweating, blurry vision, dizziness, headache, and sleepiness. Cogmed may also cause allergic reactions in some patients. Although rare, patients may also experience more serious side effects like breathing difficulties. Patients should inform their doctor of any common adverse effects while taking cogmed. [Withpower (www.withpower." - Anonymous Online Contributor

Unverified Answer

How serious can opioid abuse be?

"There are alarming percentages of patients treated for opioid use disorders who continue to misuse opioids. Although the number of patients who discontinue using opioids after treatment in the course of care remains unclear, patient, physicians' and professional interest in opioid treatment may be a limiting and underserving factor. This may be due to the fact that treatment in the course of care is typically short-term whereas detoxification, with a prolonged abstinence, as the primary goal of treatment, is perceived as a more challenging task than to facilitate gradual weaning/withdrawal." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating opioid abuse?

"Clinicians and family members have a vital role in recognizing the seriousness of this problem. To address this problem, research needs to be done on pharmacological means to treat opioid use." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Drug Abuse by sharing your contact details with the study coordinator.