Tai Ji Quan for Mild Cognitive Impairment

Overseen By Fuzhong Li, Ph.D.

Age: 65+

Sex: Any

Trial Phase: Academic

Sponsor: Oregon Research Institute

Disqualifiers: Metastatic cancer, Severe cardiac failure, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 24 weeks

332 Participants Needed

Trial Summary

What is the purpose of this trial?

To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.

Research Team

Fuzhong Li, Ph.D.

Principal Investigator

Oregon Research Institute

Eligibility Criteria

This trial is for older adults with mild cognitive impairment who can safely exercise and have a CDR score ≤0.5 and MMSE ≥24, indicating normal general cognitive function. They must be willing to follow the study's protocol for 24 weeks plus a 6-month follow-up but not already engaged in Tai Ji Quan or similar vigorous physical activities.

Inclusion Criteria

Clinical dementia rating (CDR) scale score ≤0.5

Having normal general cognitive function screened, with MMSE ≥24

My doctor says I can safely exercise.

Exclusion Criteria

I do not have any health conditions like severe heart failure or cancer spread that would limit my physical activity or survival.

You have been doing intense physical activities like Tai Ji Quan, brisk walking for 30 minutes or more at a time, or weight lifting on 3 or more days per week for the past 3 months.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in Tai Ji Quan-based exercises designed to improve cognitive function, dual-task ability, strength/balance, and mobility

24 weeks

Regular sessions (in-person)

Follow-up

Participants are monitored for changes in cognitive function, physical performance, and quality of life

4 weeks

Treatment Details

Interventions

• The Go for Exercise & Healthy Aging Project

Trial Overview The trial tests 'Tai Ji Quan: Moving to Maintain Brain Health,' an exercise program designed to improve overall brain function and the ability to do two things at once (dual-task ability) in older adults with mild cognitive issues.

Participant Groups

Group I: Cognitively enhanced Tai Ji Quan Experimental Treatment 1 Intervention

Participants in this arm will exercise a series of Tai Ji Quan-based movements with configurations that are specifically designed for older adults to improve cognitive function, dual-task ability, strength/balance, and mobility.

Group II: Standard Tai Ji Quan Active Control 1 Intervention

Serving as an active comparison arm, participants in this intervention will exercise a series of Tai Ji Quan-based movements that are specifically designed for older adults to improve strength/balance, cognitive function, and mobility.

Group III: Stretching Placebo Group 1 Intervention

Serving as a control arm, participants in this intervention will engage in a series of light exercise activities consisting of breathing, stretching, and body relaxation.

Who Is Running the Clinical Trial?

Oregon Research Institute

Lead Sponsor

Trials

87

Recruited

62,600+