Popular Trials
Vitamin
Vitamin D + Fish Oil for Health Improvement
This trial is studying whether taking daily dietary supplements of vitamin D3 or omega-3 fatty acids reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses.
Behavioural Intervention
IPSRT + Healthy Lifestyle Intervention for Bipolar Disorder Risk
This trial tests a telehealth therapy called IPSRT to help children at high risk of bipolar disorder due to having a bipolar parent. The therapy focuses on improving sleep and daily routines to prevent the disorder. The study will monitor outcomes over time. Interpersonal and Social Rhythm Therapy (IPSRT) was specifically developed to manage stressful life events, improve disruptions in social and circadian rhythms, and has shown efficacy in treating bipolar disorder.
Behavioral Intervention
Improved Perioperative Preventive Measures for Surgical Site Infections
This trial is testing a multifaceted program to see if it can reduce surgical site infections (SSIs). The program includes improved basic perioperative preventive measures. The investigators aim to examine the relative effectiveness of each component of this program in controlling ESKAPE transmission and reducing SSIs and to identify an optimal implementation strategy for national dissemination.
Behavioural Intervention
Fall Prevention Program for Older Adults
This trial is studying a new way to prevent falls in older adults that includes an evaluation by a physical therapist and pharmacist in addition to the usual care by an ED clinician. The study will last for 12 months and measure recurrent falls.
Behavioral Intervention
Fuerte Program for Psychological Trauma in Immigrant Youth
This trial will test the efficacy of a school-based group prevention program called Fuerte, which is designed to help newcomer Latinx immigrant youth who are at risk of experiencing traumatic stress. The program will be implemented by mental health providers from various county community-based organizations, as well as from the SFUSD Wellness Centers.
Popular Filters
Trials for Prediabetes Patients
Biguanides
Lifestyle Changes + Metformin for Diabetes Prevention
This trial looks at the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population. Lifestyle reduced diabetes onset by 58% and metformin reduced diabetes onset by 31%.
Behavioral Intervention
Diabetes Genetic Counseling for Obesity
This study will examine the impact diabetes genetic counseling on patient motivation and disease prevention behaviors among subjects with pre-diabetes. Intervention subjects will be provided with their individual diabetes genotype risk score derived from aggregating the combined results of 37 diabetes risk-associated genetic loci. Controls will not be tested. All subjects will be enrolled in a 12-week diabetes prevention program.
Behavioral Intervention
Chronic care management 1-6 for High Blood Pressure
CONTEXTE: L'Agence de la santé et des services sociaux de Montréal (ASSS) invited our research team to evaluate the implementation of an integrated and interdisciplinary primary care network for prevention and management of cardiometabolic risks (diabetes and hypertension) (PCR). The intervention is based on the Chronic Care Model and the development of an integrated services network. PCR is to be implemented in 6 territories of "Centre de santé et de services sociaux (CSSS)". A first application for funding was made to Fonds Pfizer-FRSQ-MSSS for an evaluation that has to be completed in the first 24 month after the beginning of the implementation. This application to the PHSI program at CIHR is complementary and will ensure an evaluation of the sustainability of PCR and of long term effects (40 months after the beginning of the implementation) for patients and for their primary care physicians. In each CSSS, PCR plans for : 1- an interdisciplinary team in an education center working with primary care physicians and offering to referred patients a pre-determined sequence of clinical interventions over a 2-year-period; 2- a program supporting primary care physicians (continuing education, documentation and clinical guidelines, referral system to second line of care); 3- networking between actors of "Réseau local de services (RLS)" insuring clinical information transfer required for efficient patient management. OBJECTIVES: 1-evaluate PCR effects according to territory, time and degree of exposure (specifically benefits to registered patients and support to participating primary care physicians); 2- identify the degree of implementation of PCR in each CSSS territory and the related contextual factors; 3- examine the relationship between the effects identified, the degree of implementation of PCR and the related contextual factors; 4- assess the impact of implementing PCR on the strengthening of RLS. METHODS: The proposed evaluation will be done through a mixed design including two complementary strategies. Using a "quasi-experiment/before-after" design, the first strategy is a quantitative approach looking at the program effects and their variation between territories. This analysis will use data from the PCR clinical database (ex.: HbA1c, BP, lifestyle) and from patient questionnaire inquiring about care experience, utilization of services, chronic care follow-up, self-management and quality of life. Around 3000 patients will be enlisted. A primary care physician questionnaire will enquire about PCR effects on their practice. Using primarily a qualitative and a case study approach, each of the 6 territories being one case, the second strategy will identify the degree of implementation of PCR and the explanatory contextual factors. This analysis with use data obtained from semi-structured interviews with program managers. The results of this analysis will be summarized in a monograph for each territory. According to the type of indicator analyzed, objective 3 will be fulfilled using linear models or longitudinal multilevel models supplemented with an interpretive approach using the information from monographs and discussion groups. The impact of implementing PCR on RLS will be assessed through interviews with key informants. RESULTS AND EXPECTED IMPACT: Our study will identify the effectiveness of PCR and contextual factors associated with successful implementation and sustainability of PCR. Detailed contextual information will allow application of our results to other environments that have similar context and to other chronic conditions that could benefit from an integrated services network. KNOWLEDGE TRANSFER: Since decision makers, clinicians and researchers did and will take part in all phases of PRC evaluation (planning, data collection, analysis and interpretation), diffusion of information regarding the program is an integral part of the research process. In addition, results will be presented at local, regional, provincial and national conferences and published in reports and articles widely distributed. More specifically, a regional symposium will be organized to share evaluation results with all CSSS in the region (n=12) and with all our local and regional partners.
Behavioral Intervention
Peer-led intervention +1 More for Diabetes
The prevalence of obesity and diabetes in older adults is increasing. Because older adults are often portrayed as less likely to change long-standing health behaviors, health promotion in this age group has lagged behind others. In fact, little attention has been given to the importance of diabetes prevention in community-dwelling older adults through the implementation of programs that promote healthy nutrition, increase physical activity and improve self-management. The Diabetes Prevention Program (DPP), which demonstrated the benefit of modest weight loss on the reduction of diabetes risk (58% overall reduction with a 71% reduction in the older population), has yet to be translated into widespread public health practice. The overall objective of this protocol is to implement evidence-informed, innovative interventions to increase adoption of findings from comparative effectiveness research (CER) for diabetes management and prevention in South Florida older veterans. Specifically, the proposed study will test the hypothesis that Peer-led Care alone (PC), or activated by technology (TechnAlert-Peer or TAP), is superior to traditional methods of information dissemination (Usual Care or UC) for adoption of CER on prevention and management of diabetes, leading to better self-efficacy and clinical outcomes. The investigators will conduct a 12-month randomized controlled trial in older veterans with prediabetes and diabetes participating in one of the Healthy Aging Regional Collaborative programs. Primary outcomes include changes in self-efficacy, weight, and hemoglobin A1c. Secondary outcomes include changes in blood pressure, lipids, physical function, quality of life, and health care utilization and the evaluation of potential racial/ethnic disparities in the process of adoption of CER for prevention and management of diabetes. This study is expected to accelerate the implementation of CER evidence for diabetes prevention, addressing health and economic challenges in the care of overweight and obese veterans.
Phase 3 Trials
Biguanides
Lifestyle Changes + Metformin for Diabetes Prevention
This trial looks at the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population. Lifestyle reduced diabetes onset by 58% and metformin reduced diabetes onset by 31%.
Vasodilator
Nitroglycerin +1 More for Raynaud's Disease
The purpose of this research study is to test the safety, tolerability, and effectiveness of Topical AmphiMatrix with Nitroglycerin (MQX0503) to relieve Raynaud's symptoms and increase blood flow to the fingers.
Trials With No Placebo
Behavioral Intervention
Weight-Loss Program with Mobile Tracking for Obesity
This trial tests a program called H.E.A.L.T.H. Intensive, which helps Army Soldiers manage their weight and fitness using an app and smart devices. The program tracks their activity and weight, providing personalized advice without needing clinic visits. It aims to help Soldiers meet fitness standards and improve overall well-being.
Behavioural Intervention
Risk-Based Screening for Breast Cancer
This trial is comparing annual breast cancer screening to a risk-based breast cancer screening schedule. The goal is to see if the risk-based schedule detects breast cancers earlier and causes fewer false positives.
Behavioral Intervention
Counseling for Depression and Suicide Risk
This trial is testing whether an anonymous online screening for stress, depression, substance use, and suicidal thoughts will help medical trainees and faculty who are in distress. It is expected that the screening will make them more likely to come for counseling and that their suicide risk factors will be lower after they receive treatment.
View More Related Trials
Frequently Asked Questions
Introduction to prevention
What are the top hospitals conducting prevention research?
When it comes to groundbreaking clinical trials in the field of prevention, several top hospitals across the United States are making notable strides. Brigham and Women's Hospital in Boston leads the way with six active prevention trials aimed at identifying strategies to ward off various diseases. While they have yet to conduct any prevention trials historically, their commitment to preventive medicine is evident. Similarly, Mayo Clinic in Rochester is actively engaged in four ongoing prevention studies, focusing on innovative approaches to disease prevention. Although they also do not have a past record of conducting preventive trials, their dedication towards exploring preventative measures is commendable.
In Aurora, Colorado, Children's Hospital Colorado recognizes the importance of early intervention and has three active prevention trials underway. These efforts aim to identify ways to prevent or mitigate health issues from an early age and support children's well-being as they grow up.
Meanwhile, Dent Neurologic Institute located in Amherst acknowledges that preventing neurological disorders carries immense significance for overall health outcomes. They currently contribute by running three active clinical trials focused on preventive strategies within this realm.
Lastly,nestled away in Bellevue,the Northwest Clinical Research Center signifies its role as a crucial player by hosting three ongoing preventive clinical investigations without prior historical input.Their current endeavors involve pioneering research into preventative measures against various conditions related issues emphasizing their contribution towards ensuring healthier lives
These esteemed institutions demonstrate unwavering commitment toward mitigating risks before diseases surface and promoting overall wellness through proactive approaches.Across different locations these top-tier hospitals exemplify how ongoing collaborative work continues driving us closer than ever before towards cultivating healthier lives for everyone
Which are the best cities for prevention clinical trials?
When it comes to prevention clinical trials, several cities have emerged as leaders in research and development. Boston, Massachusetts leads the way with 18 active trials focusing on interventions like Enteric Coated Aspirin, Deferoxamine, and Vitamin d. New york, New York follows closely behind with 13 ongoing studies examining strategies such as targeted screening advice based on comprehensive risk assessments. Miami, Florida; Phoenix, Arizona; and Baltimore Maryland also contribute significantly to prevention research with their own set of active trials exploring various preventive measures. These cities offer individuals opportunities to participate in cutting-edge clinical trials aimed at preventing diseases and improving overall health outcomes.
Which are the top treatments for prevention being explored in clinical trials?
When it comes to prevention, clinical trials are currently investigating the efficacy of several promising treatments. The top contenders in these trials include:
- Daratumumab: Being tested in multiple ongoing trials
- Belantamab mafodotin: Showing potential as a preventive treatment
- Lenalidomide: Under investigation for its preventive properties
These treatments hold promise for preventing breast cancer and may provide a breakthrough in the fight against this disease. Continued research and development are crucial to improving prevention strategies and ultimately reducing the burden of breast cancer worldwide.
What are the most recent clinical trials for prevention?
Exciting advancements are being made in the realm of prevention, as recent clinical trials offer promising approaches to safeguard against various health conditions. Among these studies is a Phase 2 trial investigating the efficacy of high-dose ORC-13661 for prevention. Additionally, a Phase 3 trial called ReMMiD-C Therapeutic Arm A aims to explore preventive strategies further. Another Phase 3 trial named ROSE (Reach Out, Stay Strong, Essentials) focuses on preventing complications in mothers with newborns. Furthermore, a Phase 2 trial examines the potential benefits of smartphones in preventive measures. Lastly, Stellate ganglion block is being explored through both Phase 2 and Phase 3 trials for its preventative properties. With these innovative initiatives underway, we can anticipate significant progress in disease prevention efforts moving forward.
What prevention clinical trials were recently completed?
Recently, several clinical trials focused on prevention have concluded, providing valuable insights into strategies for disease avoidance. These studies demonstrate the commitment of researchers to proactively addressing health concerns.